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OBJECTIVES: Expression of uPA mRNA is massively up-regulated in the stroma of poorly differentiated ovarian tumors. We hypothesized that this expression was induced by paracrine signals from the epithelial tumor cells, and established an in vitro model of ovarian cancer microenvironment to study intercellular cross-talk. METHODS: ES-2 clear cell carcinoma cells were grown in tissue culture inserts
BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury is a pivotal mechanism in critical illness and in the development of multiple organ dysfunction syndrome, in which the nuclear factor kappa B (NF-κB) activation plays a central role. Intestinal I/R injury initiates the extrinsic tissue factor or factor VIIa-dependent pathway of coagulation, also of importance in multiple organ dysfuncti
Introduction: Assay discrepancy in factor VIII activity between the one-stage and the chromogenic assays has been described in approximately one third of patients with non-severe haemophilia A. Whether assay discrepancy may also occur in patients with haemophilia B remains unknown. Aim: This study compared the results from the one-stage and the chromogenic assays in patients with haemophilia B. Me
Dynamic global vegetation models (DGVMs) are designed for the study of past, present and future vegetation patterns together with associated biogeochemical cycles and climate feedbacks. However, most DGVMs do not yet have detailed representations of permafrost and non-permafrost peatlands, which are an important store of carbon, particularly at high latitudes. We demonstrate a new implementation o
Tre borrkärnor bestående av sjösediment, vardera 1.5 meter långa, från Byestadsjön i Småland, Sverige studerades med hjälp av mineralmagnetiska- kol- pollen- och röntgenflourosens (XRF)- analyser. Målet med studien var att rekonstruera tidig Holocen miljö, med fokus på tiden mellan 9000-7000 år sedan och därmed avgöra om det kalla klimatåterslaget cirka 8200 före nutid påverkade regionen eller ej.Three sediment cores, each 1.5 meters in length, obtained from Lake Byestadsjön in the province of Småland, southern Sweden were studied with high resolution mineral magnetic measurements, carbon content, pollen analysis and XRF analysis. The aim was to reconstruct the early Holocene environment, with focus on the period between 9000-7000 cal yr BP, and thereby conclude if the 8200 cal yr BP cooli
A personal transporter is under development at LTH, Industrial Electrical Engineering and Automation, IEA. A wireless link is desired to develop control remotely for the transporter. The development of the control becomes easier without wires and if the transporter can move freely within the range of the link. A link is built, using Bluetooth devices and a microprocessor from Microchip. This link
Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
INTRODUCTION: The prognosis for patients with melanoma has improved due to better treatments in recent years and updated tools to accurately predict an individual's risk are warranted. This study aims to describe a prognostic instrument for patients with cutaneous melanoma and its potential as a clinical device for treatment decisions.METHODS: Patients with localised invasive cutaneous melanoma di
BACKGROUND: ACURATE neo2 is a transcatheter aortic valve implantation system consisting of a self-expanding bioprosthetic valve with supra-annular leaflet position and featuring innovations to facilitate placement accuracy and reduce paravalvular regurgitation. METHODS AND RESULTS: The goal of the Early neo2 (Early neo2 Registry of the ACURATE neo2 TAVI Prosthesis) was to gather real-life data on
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. Arc capsids, released from neurons, have been proposed as a novel intercellular mechanism for mRNA transmissi
Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B
BACKGROUND: Asthma is the most frequent chronic disease in children. One of the most replicated genetic findings in childhood asthma is the ORMDL3 gene confirmed in several GWA studies in several paediatric populations.OBJECTIVES: The purpose of this study was to analyse ORMDL3 variants and expression in childhood asthma in the Polish population.MATERIALS AND METHODS: In the study we included 416
OBJECTIVE: To characterize 414 patients with primary SS who developed hematological malignancies and to analyze how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes.METHODS: By January 2021, the Big Data Sjögren Project Consortium database included 11 966 patients fulfilling the 2002/2016 classification criteria. Hematological malignancies diagnosed acco
Epilepsy is a severe neurological disease manifested by spontaneous recurrent seizures due to abnormal hyper-synchronization of neuronal activity. Epilepsy affects about 1% of the population and up to 40% of patients experience seizures that are resistant to currently available drugs, thus highlighting an urgent need for novel treatments. In this regard, anti-inflammatory drugs emerged as potentia
Bacterial adhesion to the host is the most decisive step in infections. Trimeric autotransporter adhesins (TAA) are important pathogenicity factors of Gram-negative bacteria. The prototypic TAA Bartonella adhesin A (BadA) from human-pathogenic Bartonella henselae mediates bacterial adherence to endothelial cells (ECs) and extracellular matrix proteins. Here, we determined the interaction between B
Winter warming events (WWE) are abrupt and short-lasting (hours-to-days) events of extraordinarily warm weather occurring during wintertime, sometimes accompanied by rainfall (rain on snow events; ROS). Through direct heat transfer and changes in the snowpack properties, these events cause changes in the below-ground thermal regime that, in turn, controls a suite of ecosystem processes ranging fro
