Filtyp
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st
Objective To investigate the relationship between active commuting and atherosclerosis in middle age using state-of-the-art coronary CT angiography (CCTA). Methods This cross-sectional study used data from the Swedish CArdioPulmonary bioImage Study (SCAPIS) and included 23 722 randomly recruited individuals aged 50–64 years from six different regions in Sweden. The exposure was commuting mode, ass
Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros
A clear understanding of the mechanisms governing the growth of nanowires is crucial to achieving control over their structures and properties. Here, we employ molecular dynamics (MD) simulations to investigate several important phenomena in Au-catalyzed Si nanowires (SiNWs) grown via the vapor–liquid–solid method. MD simulation serves as a complementary tool for uncovering the mechanisms of nanow
In the aftermath of the Covid-19 pandemic, the accelerated shift to remote and hybrid work modes has left many office buildings vacant. Meanwhile, many cities struggle with providing housing. Adaptive reuse (AR) is the process of giving an existing building a new life, typically through an extensive renovation and refurbishment. Residential adaptative reuse specifically refers to adapting for hous
Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of
A peptide corresponding to a 13-residue segment of the human protein semenogelin I has been shown to generate a hydrogel consisting of amyloid-like fibrils. The relative chemical diversity (compared to synthetic de novo sequences) with 11 distinct amino acids makes this peptide (P0) an ideal candidate for investigating the role of individual residues in gelation. Herein, the N-terminal residues ha
During peritoneal dialysis (PD), a major portion of the osmotically induced water transport to the peritoneum can be predicted to occur through endothelial water-selective channels. Aquaporin-1 (AQP-1) has recently been recognized as the molecular correlate to such channels. Aquaporins can be inhibited by mercurials. In the present study, HgCl2 was applied locally to the peritoneal cavity in rats
New anti-inflammatory drugs with fewer adverse effects than existing drugs may prove to be useful in the treatment of several inflammatory disorders. A critical step in acute inflammation is the infiltration of neutrophils into tissues. Therefore, molecules that target and inhibit this early inflammatory event are attractive to engineer to suit medical needs. The Chemotaxis Inhibitory Protein of
Popular Abstract in Swedish En enkel beskriving av atomen kan utgå från Bohrs atommodell (som emellertid ej är användbar för en exaktare beskrivning): runt kärnan, som består av positivt laddade protoner och neutrala neutroner, kretsar elektroner. Vilket grundämne det är bestäms av antalet protoner i kärnan. Antalet elektroner för en atom är detsamma som antalet protoner i kärnan. Tillförs atomen Atomic data are needed in many different areas of science and technology. Examples of users are the astronomical community and the lighting industry. In this work, the purpose of the projects has been to produce reliable atomic data needed to solve specific astrophysical problems. Oscillator strengths, which are needed when analysing stellar absorption spectra as well as spectra of emission line o
Popular Abstract in English The cell is the basic unit in all organisms. The molecular machinery in cells converts the energy in sunlight or food into a form of energy that the cell can use for physiological processes in the organism. In humans, this molecular machinery is located in the mitochondria; therefore they are often called the power plants of the cell. The molecular machines are actuallyNADH:quinone oxidoreductase, or complex I, is a large membrane bound enzyme in the respiratory chain of living organisms, that has evolved from the combination of smaller functional building blocks. The enzyme has a conserved core structure, comprising 14 protein subunits: Seven subunits protrude from the membrane and contain a flavin and eight iron-sulfur clusters. The remaining seven subunits in
Popular Abstract in Swedish Osteoporos (benskörhet) är en sjukdom som drabbar de äldre och leder till att skelettet urkalkas och därmed förlorar delar av sin styrka. Detta bidrager till olika typer av frakturer (brott av benet) där de vanligaste är handleds-, axel-, kot- och höftfrakturer. Andelen frakturer ökar i befolkningen, vilket både medför ökade kostnader för samhället och invaliditet för dThe aim of this thesis was to evaluate bone mass and bone size in girls and boys from age 12 to 16, with special attention to physical activity. We also wanted to retrospectively evaluate the effect of exercise for the years preceding age 12. The findings were as follows. Sixteen year old adolescents in a rural area had higher areal bone mineral density in the total body and the spine compared wit
Introduction: Sport-related concussions (SRC) have been a concern in all sports, including soccer. The long-term effects of soccer-related head injuries are a public health concern. The Concussion in Sport Group (CISG) released a consensus statement in 2017 and several soccer governing associations have published their own SRC guidelines while referring to it but it is unclear whether this has bee
Groundwater contamination is a threat to drinking water resources and ecosystems. Remediation by injection of chemical reagents into the aquifer may be preferred to excavation to reduce cost and environmental footprint. Yet, successful remediation requires complete contact between contamination and reagents. Subsurface heterogeneities are often responsible for diffusion into low-permeable zones, w
The introduction of atomic layer deposition (ALD), to the microelectronics industry has introduced a large number of new possible materials able to be deposited in layers with atomic thickness control. One such material is the high-κ oxide HfO2; thermally stable and ultrathin HfO2 films deposited by ALD are a significant contender to replace SiO2 as the gate oxide in capacitor applications. We pre
Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to organisms. The detailed mechanism of this enzyme is currently not known, and computational studies are complicated by the fact that different density functional theory (DFT) methods give very different energetic results for calculations involving nitrogenase models. Recently, we designed a [Fe(SH)4H]
