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The proton-translocating NADH-ubiquinone oxidoreductase (complex I) is the largest and least understood respiratory complex. The intrinsic redox components (FMN and iron-sulfur clusters) reside in the promontory part of the complex. Ubiquinone is the most possible key player in proton-pumping reactions in the membrane part. Here we report the presence of three distinct semiquinone species in compl

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Pheromone-based monitoring is a promising new method for assessing the conservation status of many threatened insect species. We examined the versatility and usefulness of pheromone-based monitoring by integrating a pheromone–kairomone trapping system and pitfall trapping system in the monitoring of two saproxylic beetles, the hermit beetle Osmoderma eremita (Coleoptera: Scarabaeidae) and its pred

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It was previously shown that letrozole (Femara(R)) was significantly more potent than anastrozole (Arimidex(R)) in inhibiting aromatase activity in vitro and in inhibiting total body aromatisation in patients with breast cancer. The objective of this study was to compare letrozole (2.5 mg per day) and anastrozole (1 mg per day) as endocrine therapy in postmenopausal women with advanced breast canc

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Steller's Eider Polysticta stelleri has a restricted arctic breeding range. The world population declined to c. 220,000 individuals in the late 1990s from an estimated 400,000-500,000 in the 1960s. The species has a limited global wintering distribution, occurring in marine habitats in north-east Europe, islands close to Kamchatka in Russia, and the eastern Aleutian Islands and south-west Alaska.

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Adsorption of Co(II) at the aqueous interfaces of ZnO and ZnS (wurtzite) has been studied by classical wet-chemical methods, and the structure and composition of Co adsorption complexes at these interfaces have been determined by in-situ X-ray absorption fine structure (XAFS) spectroscopy. On both adsorbents, adsorption as a function of pH shows the normal behavior, i.e., a pronounced adsorption w

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Popular Abstract in Swedish Under 9 år (1989-1997) studerades individuellt märkta mindre hackspettar i ett undersökningsområde i södra Smålands ädellövskogar. De flesta studierna gjordes i 17 potentiella revir, vilka undersöktes årligen. Följningar av hackspettar försedda med radiosändare visade att fåglarna rörde sig inom ett, i medeltal, 742 ha stort hemområde under vintern. Under häckningstideOver 9 years, 116 breeding attempts made by individually marked lesser spotted woodpeckers (Dendrocopos minor) were followed in a study area in southern Sweden. The home-range area decreased from on average 742 ha in winter to a defended territory of 103 ha prior to breeding and 43 ha during nesting. The annual timing of the breeding varied between years but was each year synchronized with the bu

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Technology transfer is important to understand how knowledge is transformed to economic value. Applying a case study approach, this thesis investigates the technology transfer efforts from the University of Dar Es Salaam to indigenous informal SMEs in Tanzania and examines the impact of one of their technology transfer mechanisms on the specific technological capabilities that were acquired at the

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This thesis presents two new technologies, SIRE technology based biosensors and magneto immunoassays, which can be used for bioanalytical applications. One of the main problems associated with biosensor technology is the instability of the recognition element since it is of biological origin and thus, has a limited lifetime. Conventionally, this problem has been solved by immobilizing the biologic

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Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. RA is a common autoimmune disorder that affects approximately 1% of the population and knowledge of the contributing genetic factors would greatly incr

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This study describes, in quantitative terms, the effects of endothelin-2 and endothelin-3 on vascular tone (resistance) in large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 microns) and the veins, as well as on capillary pressure and fluid exchange in cat gastrocnemius muscle in vivo. Infusion of endothelin-2 or endothelin-3 (200-1600 ng kg-1 min-1, i.a.) elicited an in

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Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning Kvartärtidens avlagringar döljer mycket och detaljerad information om palaeoklimatet och de lämpar sig därför väl för att modellera palaeoklimatets förändringar. Inlandsisar är av avgörande betydelse för klimatet under kvartärtiden. Deras tillväxt och avsmältning beror till stor del på klimatiska faktorer, såsom temperatur, nedeThis thesis presents results from studies on geomorphology, lithostratigraphy and ice flow patterns during the final termination and deglaciation of the last Scandinavian Ice Sheet in NE Germany. Ice flow patterns derived from till fabrics and glaciotectonical data indicate that short-lived marginal domes had formed during the advance and the retreat of the last Scandinavian Ice Sheet in NE German

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OBJECTIVE: We sought to study changes in morphology and stent-graft configuration of descending thoracic aortic aneurysms after endovascular repair. METHODS: Twenty-three patients treated with custom-made stent-grafts were studied. The stent-graft consisted of continuous, stainless-steel Z stents mounted within a polyester graft. In the last 11 cases the stents were interconnected with 3 longitudi

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We report karyotypic features of 106 short-term cultured oral squamous cell carcinomas (SCC), 51 new and 55 previously reported cases, with clonal chromosome aberrations. The major cytogenetic findings were as follows: simple karyotypic changes were present in 38 cases (36%) and 68 tumors (64%) displayed complex karyotypes. The most common numerical changes were +7, +8, +9, +16, +18, +20, and -4,

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Electronic and structural properties of Sb-induced GaAs(100)(2x4) and (2x8) surfaces are studied by means of core-level and valence-band photoelectron spectroscopy utilizing synchrotron radiation and scanning tunneling microscopy. Combining these results and showing good consistency among them, we demonstrate that the Sb/GaAs(100)(2x4) surface is well compatible with the delta structural model, wh

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Bacterial genomes typically consist of a single chromosome and, optionally, one or more plasmids. But whole-genome sequencing reveals about ten per-cent of them to be multipartite, with additional replicons which by size and indispensability are considered secondary chromosomes. This raises the questions of how their replication and partition is managed without compromising genome stability and of

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Zebrafish is emerging as a complement to mammals in behavioral studies; however, there is a lack of comparative studies with rodents and humans to establish the zebrafish as a predictive translational model. Here we present a detailed phenotype evaluation of zebrafish larvae, measuring 300-3000 variables and analyzing them using multivariate analysis to identify the most important ones for further