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Objective: Immediate cartilage structural alterations in the acute phase after an anterior cruciate ligament (ACL) rupture may be a precursor to posttraumatic osteoarthritis (PTOA) development. Our aim was to describe changes in cartilage matrix in the subacute phase of the acutely ACL-injured knee compared to the contralateral uninjured knee. Design: Participants (n = 118) aged 15–40 years with a
Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D
The interaction of protein S with membranes and subsequent combination with complement C4b-binding protein (C4BP) was studied. Protein S interacted with phospholipid vesicles in a calcium-dependent manner typical of other vitamin K-dependent proteins. Association of C4BP with protein S showed no apparent selectivity for membrane-bound or solution phase protein S. When bound to the membrane, the pr
Introduction: Primary health care centers (PHCCs) in Sweden are struggling to maintain a balance between increasing demands of service and supervision and learning activities for a growing number of students. We sought a deeper understanding of primary care physicians and managers behavioral intention towards supervising, and their perceptions of the structural preconditions and support needed.Met
Summary: This narrative review describes efforts to improve the care and prevention of fragility fractures in New Zealand from 2012 to 2022. This includes development of clinical standards and registries to benchmark provision of care, and public awareness campaigns to promote a life-course approach to bone health. Purpose: This review describes the development and implementation of a systematic a
BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide level. Our aim is to enhance understanding of familial risks in childhood nervous system cancers. Methods: We used the Swedish population and cancer data from years 1958–2021 to a
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in
Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi
There is a global concern about the decline of wild pollinators and the ecosystem services they provide. Although land-use change is a major threat to biodiversity, it is still poorly understood how land-use heterogeneity (or land-use structure) impacts pollinator communities and entomophilous crop production. Based on a literature review, we performed a meta-analysis to (1) assess how landscape s
Determining the appropriate duration for traffic conflict observation remains a critical yet unresolved challenge in road safety analysis. Existing approaches lack a quantitative approach to determine adequate sample sizes for general conflict-based applications. This study addresses this gap by proposing an extreme value theory based framework to determine appropriate observation durations, based
Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m
Endowed with diverse vegetation covers, the Middle Atlas Mountains receive substantial snowfall in winter, which contributes to plant hydration during the growing season. Using remotely-sensed imagery, this study aims to assess the trends in snow cover variations between 2000 and 2015, analyse the local influence of snowpack persistence on vegetation growth and evaluate the significance of this ef
Sammanfattningsvis består arbetets problemställning av: • Presterar kv Betan enligt den energiprestanda som huset är projekterat för och är kv Betan ett bra projekt att använda som referens? • Hur fungerar erfarenhetsåterföring inom Företaget idag och hur kan hantering av information förbättras? Vilka verktyg behövs för att förenkla Företagets sätt att arbeta med projekt som kräver mätning och ko
Hot och våld förekommer ofta inom de särskilda ungdomshemmen och behandlingsassistenterna som arbetar närmast de unga, är de som är mest utsatta för hot och våld. Att arbeta i en miljö där risken för att utsättas för hot och hot om våld utgör en väsentlig arbetsmiljörisk och medför även stora påfrestningar för personalen. De teorier som tillämpats är Libskys (1980) teori om gräsrotsbyråkratin, Go
Utveckling av jordbrukssektorn är en av de viktigaste prioriteringarna för den Etiopiska staten när det kommer till att upprätthålla landets ekonomiska utveckling. Ett sätt att uppnå detta är att satsa på storskaliga utvecklingsprojekt inom jordbruket, till exempel Tana Beles Sugar Development Project som den här uppsatsen kretsar kring. För att kunna anlägga detta har stora landarealer tagits i aDevelopment of the agricultural sector is among the top priorities for the Ethiopian government in order to keep up the economic development in the country. One way of reaching this is to undertake large-scale development projects, such as the Tana Beles Sugar Development Project described in this thesis. For this, large areas of land are required for the plantations. This land is expropriated fro
År 2006 var året då fler människor bodde i städer än på landsbygden och år 2030 uppskattas 5 miljarder människor bo i en urban miljö. Att lösa boendesituationen för de som flyttar till städer är ett globalt problem som kommer bli viktigare än någonsin tidigare att lösa. (Montgomery, 2014) Bostadsbyggandet i Sverige har de senaste åren ökat, men befolkningen ökar i ännu högre takt vilket gör att bo2006 was the year when more people lived in cities than in rural areas and by 2030 approximately 5 billion people will be living in an urban environment. Solving the housing situation of those who move to cities is a global problem that will become more important than ever to solve. (Montgomery, 2014) Housing construction in Sweden has increased in recent years, but the population is increasing at
Den kunskap en arbetstagare har utgör en av de primära tillgångarna i en näringsverksamhet. Uppdelningen mellan vilken information som tillfaller arbetsgivaren och vilken information som utgör personligt kunnande blir framförallt aktuell då en anställning upphör. Situationen att arbetstagaren byter arbete till en anställning inom samma verksamhetsområde är mer regel än undantag. Det är viktigt förThe knowledge that workers possess is one of the primary assets of a business. The divisions between which information that belongs to the employer, and which information an employee can bring into a new employment become relevant when the employment terminates. In the late spring of 2016 the European Commission and the European Council approved a directive about the protection for trade secrets t
