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A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations
Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa
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Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats
The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t
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Språk- och litteraturcentrum Franska Litteraturlista FRAM19, franska, Modern språkvetenskaplig teori med tillämpning på franska, 15 högskolepoäng Fastställd av Styrelsen för Sektion 3 2023-06-08 att gälla från HT2023 Obligatorisk litteratur Kleiber, Georges (1990). La sémantique du prototype. Paris: Presses universitaires de France. ISBN 9782130428374. Kapitel 1-4. (140 s.) Moeschler, Jacques & Re
https://www.sol.lu.se/media/utbildning/dokument/kurser/FRAM19/20242/FRAM19.pdf - 2026-05-28
The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies.
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Expression of a Core 3 Disialyl-Le(x) Hexasaccharide in Human Colorectal Cancers: A Potential Marker of Malignant Transformation in Colon.
Cancer-associated alterations in cell surface and secreted glycoproteins have been catalogued for many years but many of the studies of alterations in mucin carbohydrate have relied on histochemical or immunohistochemical methods, with little direct chemical analysis. In this study, we analyzed the O-glycosylation pattern of MUC2 glycoprotein isolated from colorectal carcinomas, transitional mucos
The Core and Specifics of Mandarin Chinese marker le: A unified approach and a Cognitive Grammar representation
LES of Supersonic Combustion in a Mach 2 Cavity-Based Model Scramjet Combustor with Conjugate Heat Transfer and Radiative Heat Transfer
Comparison of LES Models Applied to a Bluff Body Stabilized Flame
LES of supersonic combustion in a scramjet engine model
Climate-driven changes in lake conditions during late MIS 3 and MIS 2: a high-resolution geochemical record from Les Echets, France
The lithostratigraphy of the Les Echets basin, France: tentative correlation between cores
Taking Issue With Le Poidevin's New Agnosticism
LES of H2-air jet combustion in high enthalpy supersonic crossflow
Combustion LES of a multi-burner annular aero-engine combustor using a skeletal reaction mechanism for jet- a air mixtures
In this study we describe combustion simulations of a single sector and a fully annular generic multi-burner aero-engine combustor. The objectives are to facilitate the understanding of the flow, mixing and combustion processes to help improve the combustor design and the design process, as well as to show that it is now feasible to perform high-fidelity reacting flow simulations of full annular g