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Aim The northern limits of temperate broadleaved species in Fennoscanndia are controlled by their requirements for summer warmth for successful regeneration and growth as well as by the detrimental effects of winter cold on plant tissue. However, occurrences of meteorological conditions with detrimental effects on individual species are rare events rather than a reflection of average conditions. W
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-OHDA concentration (3.2μg/μl) in C57BL/6 mice. In the first experiment, toxin injections were performed either at two striatal coordinates (1 or
Recently, the lineage hTURDUS2 of Haemoproteus minutus (Haemosporida, Haemoproteidae) was reported to cause mortality in captive parrots. This parasite lineage is widespread and prevalent in the blackbird Turdus merula throughout its entire distribution range. Species identity of other closely related lineages recently reported in dead parrots remains unclear, but will be important to determine fo
This report describes a model for the estimation of the time required to evacuate a building, by dividing the evacuation process into three phases: awareness, behaviour and response, and movement. The times required in each of these phases can be estimated separately and the sum then represents the total evacuation time. The time elapsed from the fire breaking out, to the discovery of the fire, is
Cities face a host of challenges including urbanisation and climate change and must quickly adapt and integrate sustainability solutions to deal with these challenges. One platform seen as a mechanism to support innovation for sustainability in cities is the concept of the living lab. A living lab is a user-centred, open innovation ecosystem that seeks to engage academia, industry and municipaliti
The interactions between airway epithelial cells (AECs) and dendritic cells (DCs) play an important role in the sensitization towards airborne allergens. Not much is known about the underlying mechanisms and novel in vitro approaches are needed, which include the different involved cell types in order to investigate what happens at the molecular level during sensitization. In this project, one aim
In this project the aim was to design a concrete 3d printer. This report focuses on the extruder part of the printer and the printing material. The basic principle of 3d printing is that it is an additive manufacturing technique, on the contrary to the traditional subtractive manufacturing techniques. The potential benefits of concrete 3d printing compared to the techniques that are used today are
Diet is considered one of the key factors contributing to an increased risk of developing diabetes type 2. The rising prevalence of this condition is alarming and highlights the urgent need for effective nutrition-based strategies to alleviate an impending health crisis. As reoccurring hyperglycaemic episodes have been linked to an increased risk of becoming a diabetic, there is an opportunity for
Byggbranschen är i dagsläget en av de störst bidragande faktorerna till utsläpp av fossila bränslen i Sverige och besitter en stor utvecklingspotential beträffande reducering av klimatpåverkan. En byggnads klimatpåverkan under en livscykel kan beräknas genom metoden livscykelanalys, som inkluderar en produkts, eller i detta fall en byggnads, klimatpåverkan från råvaruutvinning till avfallshanterinThe construction industry is currently one of the largest contributing sources to carbon dioxide emissions in Sweden and has great development potential in reducing its climate impact. Since January 2022, the Swedish government requires a declaration of the climate impact of each recently constructed building. To calculate the climate impact of a building, the life cycle assessment tool is used, a
This thesis addresses the challenge of transforming car-oriented, mono-functional big-box landscapes into multi-functional, walkable local-centre. It assembles an integrated framework from recent research and translates it into a design approach to be tried in a case study. In contrast to the proposed multi-functional approach, a monocentric urban system concentrates functions and advantages in
Amphipyrinae have long been a catchall taxon for Noctuidae, with most members lacking discernible morphological synapomorphies that would allow their assignment to one of the many readily diagnosable noctuid subfamilies. Here data from seven gene regions (> 5500 bp) for more than 120 noctuid genera are used to infer a phylogeny for Amphipyrinae and related subfamilies. Sequence data for 57 amphipy
Smoking cessation prolongs survival and decreases mortality of patients with non-small-cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Here, we conducted an epigenome-wide interaction an
In recent years, the data science and remote sensing communities have started to align due to user-friendly programming tools, access to high-end consumer computing power, and the availability of free satellite data. In particular, publicly available data from the European Space Agency’s Sentinel missions have been used in various remote sensing applications. However, there is a lack of studies th
Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when
Purpose For over 30 years, the place of consolidation high-dose chemotherapy in Ewing sarcoma (ES) has been controversial. A randomized study was conducted to determine whether consolidation high-dose chemotherapy improved survival in patients with localized ES at high risk for relapse. Methods Randomization between busulfan and melphalan (BuMel) or standard chemotherapy (vincristine, dactinomycin
Impulsivity is common in Parkinson's disease even in the absence of impulse control disorders. It is likely to be multifactorial, including a dopaminergic 'overdose' and structural changes in the frontostriatal circuits for motor control. In addition, we proposed that changes in serotonergic projections to the forebrain also contribute to response inhibition in Parkinson's disease, based on precli
The Aim of this research is to analyze how the socio-demographic characteristics of users of Complementary and Alternative Medicine (CAM) in Serbia influence and impact their consumption of OTC drugs. Respondents and methods: The study employed the third edition of the National Health Survey of the Republic of Serbia, published in 2013, as a data source covering the Serbian population. The sample
Irradiating a flame via microwave radiation is a plasma-assisted combustion (PAC) technology that can be used to modify the combustion chemical kinetics in order to improve flame stability and to delay lean blow-out. One practical implication is that combustion engines may be able to operate with leaner fuel mixtures and have an improved fuel flexibility capability including biofuels. Furthermore,
AIMS: To determine the basal pharmacokinetics, lung uptake and plasma cortisol suppression for two commonly prescribed inhaled corticosteroids. METHODS: Twenty-one subjects (13 healthy and 8 mild asthmatic patients) received fluticasone propionate via a chlorofluorocarbon-propelled pressurized metered-dose inhaler (pMDI) (healthy subjects only) and Diskus and budesonide via Turbuhaler, 1000 microg
Nanosecond pulsed discharges (NPD) have been extensively used in plasma-assisted combustion to stimulate combustion kinetics. Experimental measurement of the energy transfer processes in non-equilibrium plasma-assisted processes is extremely difficult, as the non-equilibrium plasma discharge involves numerous different species with transient and complex three-dimensional structures across various
