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Purpose: This study quantifies the impact on budget and cost per health benefit of implementing digital breast tomosynthesis (DBT) in place of digital mammography (DM) for breast cancer screening among asymptomatic women in Italy. Methods: A budget impact analysis and a cost consequence analysis were conducted using parameters from the MAITA project and literature. The study considered four scenar
Malignant glioma is a tumor that spreads rapidly throughout brain and is almost impossible to remove completely by surgery. It is resistant to chemo- and radiotherapy and the prognosis is very poor. As a result, there is a desperate need for development of novel therapies against this devastating disease. Because of the heterogeneity in this cancer success has been limited, but a recent concept in
In the 2000s, Sweden experienced a veritable explosion of feminist performance. Although feminist actions, theatre, shows and performance existed previously, feminist events with a distinct performance approach have emerged strongly in the current decade. Feminist culture festivals are held in rapid succession, and feminist performance, dance and theatre occasionally attract broader audiences. Thi
Research Data Management (RDM) is a process that is designed to deliver high quality datasets, which comply with scholarly, legal and ethical requirements. There are two outputs of the RDM process: 1. Long term preservation of datasets through archiving 2. Sharing and reuse of datasets for further research and other purposes in society at large. This proposal outlines the creation of a coherent
Key performance indexes (KPIs) in various forms have always been used in one way or another in the production and processing of raw materials. The need for KPIs was accentuated with the advent of industrialism in the western world. The way and strategy of manufacturing industrial products has been divided into several so-called developmental transformations. Primarily after the depression of the 1
2006 antog FN:s generalförsamling Konventionen om rättigheter för personer med funktionsnedsättning (CRPD). Konventionens tillkomst sägs ofta förkroppsliga det paradigmskifte som skett vad gäller synen på människor med funktionsnedsättningar – från att tidigare betraktas som offer i behov av vård, till att ses som rättighetsbärare med krav på samhällsförändring för att kunna delta i samhället på lIn 2006, the General Assembly of the United Nations adopted the Convention on the Rights of Persons with Disabilities (CRPD). The adoption of the convention is often said to embody the paradigm shift that has taken place regarding the view of people with disabilities – from previously being regarded as victims in need of care, to being seen as rights holders with demands for social change in order
The number of electrically driven loads in a modern vehicle is constantly increasing. Many loads that former were mechanically driven will in the future be driven by electricity. This implies that a number of electronic systems have to be packed together in the limited space in a vehicle. When different electronic systems are placed close to each other, there is always a risk for electromagnetic i
Monoterpenes, primarily emitted by terrestrial vegetation, can influence atmospheric ozone chemistry, and can form precursors for secondary organic aerosol. The short-term emissions of monoterpenes have been well studied and understood, but their long-term variability, which is particularly important for atmospheric chemistry, has not. This understanding is crucial for the understanding of future
[1] Results from two deep sea cores from northeast of Newfoundland at 1251 and 2527 m water depth, respectively, indicate that during the time period from 160,000 to 10,000 years BP, ice rafting events in the Labrador Sea were accompanied by rapid variations in deep and surface water circulation. Twelve ice-rafting events occurred, each coinciding with high concentrations of detrital carbonate and
Popular Abstract in Swedish Artrit karakteriseras av svullnad och värk i leder, ledförstöring och bindvävsförstoring. Denna binvävsförstoring kallas för Pannus och är en förtjockning av det normalt förekommande synovial membranet i en led. Normalt är synovial membranets uppgift att ge näring åt det intilliggande brosket som inte självt har någon blodförsörjning. Synovial membranet innehåller ocksåRheumatoid arthritis is a chronic, inflammatory and systemic disease characterised by joint destruction and pannus formation. To enlarge the understanding how pannus and granulation tissue are formed two animal models were used; one using cartilage wrapped in cotton and implanted into a rat air pouch (AP) and one where mBSA induced arthritis (AIA) was performed. Cell cultures from synovial specime
Sustainability is a concept that has generated a great political and scientific debate during the last two decades, especially from the moment it was added to the concept of development. This has led to the distinction of two main interpretations of the term: weak and strong sustainability. The basic difference between both is that the first considers natural, manufactured and human capitals are s
There are more than eighty international agreements and many additional programmes dealing with technology transfer. Moreover, several international conventions require that aid programs, both to address acute emergencies and to assist in the longer-term building of viable infrastructures, be undertaken in specific and concrete ways. However, problems inevitably arise when good intentions are put
The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington's disease. We show in the present study that DNAJB6 also inhibits amyloid formation by an even more aggregation-prone peptide (the amyloid-beta peptide, (Aβ42)(2), implicated in Alzheimer's disease)in
Environmental and process control applications have needs for sensors that operate continuously or repeatedly, making them applicable to batch measurement and flowing product stream measurement. Additionally, for lactose monitoring in dairy-processing plants, the sensors must have sufficient flexibility to handle a wide range of substrate concentration and be resilient to withstand wide pH excursi
The thesis is a reception study and the focus of the research is on what happens during the reading process when an upper secondary school class reads fiction. The theoretical basis consists of theories of reading as transaction and the envisionment-building and dialogic classroom. A process-based and relational perspective on reading, writing and oral exchange in teaching has been central. The e
BACKGROUND: Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction. METHODS: The isometric tension was recorded in isolated segments of the rat mesenteric artery branch, before and after organ culture for 20 h. Vasodilatation was expressed a
Heparan sulfate chains have been found to be associated with amyloid deposits in a number of diseases including transmissible spongiform encephalopathies. Diverse lines of evidence have linked proteoglycans and their glycosaminoglycan chains, and especially heparan sulfate, to the metabolism of the prion protein isoforms. Glypicans are a family of glycosylphosphatidylinositol-anchored, heparan sul
This study documents the terrestrial palynological record at the John's Nose section, a new Cretaceous-Paleogene (K-Pg) boundary site in North Dakota, USA. In addition to Mud Buttes and Pyramid Butte, John's Nose represents the third K-Pg section in southwestern North Dakota that preserves direct evidence of the Chicxulub asteroid impact, allowing for direct comparison over the timing and trends o
Popular Abstract in Swedish "Män födda 1914" är en studie som påbörjades 1982 för att studera hjärt- och kärlsjukdomar. Studien bedrivs vid Institutionen för samhällsmedicin vid Universitetssjukhuset MAS. Alla män, födda jämn månad 1914 och bosatta i Malmö, inbjöds att deltaga. Totalt inbjöds 621 män, då 68 år gamla, och av dessa deltog 500. Då man jämförde deltagare med icke-deltagare kunde man k"Men born in 1914" is a prospective cohort study on the epidemiology of cardiovascular disease. The study is run by the Department of Community Medicine, Lund University, Malmö. Five hundred men participated in the study when it started with a baseline examination in 1982/83. The men were then 68 years old. The psychological part of the study included tests of cognitive function and the serial Col
