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The aim of the present study is to study the Abscopal regression of subcutaneously implanted N29 rat glioma after immunization with syngeneic IFNg secreting cells and treatment of contra-lateral tumours with pulsed electric fields (PEF) and/or radiation therapy (RT). The study was performed on rats of the Fischer-344 strain with rat glioma N29 tumours implanted subcutaneously on the flank or on bo
Objective To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA). Methods In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until the 3-4-month visit. The primary outcome measure was the DAS28-based European League against Rheumatism (EULAR) response criteria. Multivariate logistic r
Gabriela Olekszyk ALS (Airborne Lidar) accuracy: Can potential low data quality of Lidar ground points be modelled/detected based on recorded point cloud characteristics? Case study of 2016 Lidar capture over Auckland, New Zealand. Lidar (Light Detection and Ranging) data is becoming more widely available and accessible. In many cases, it can be obtained free of charge from government agencies o
Ett av Sveriges sexton miljömål är att bevara den biologiska mångfalden, alltså den mångfald av växt- och djurarter som lever i vårt land. Ett stort hot mot den biologiska mångfalden är fragmentering av de ekosystem där djuren och växterna lever. Vad innebär då fragmentering av ett ekosystem? Enkelt uttryckt kan man se fragmentering som att dela upp ett sammanhängande ekosystem i mindre utspridda The “Eastern slopes of Lake Vättern” is an area situated in the municipality of Jönköping in southern Sweden. The area has a high level of biodiversity of which much is bound to mixed broad-leaved deciduous trees and forests and contains species that are unique for this area in Sweden. The area is a candidate to become a biosphere reserve under the Unesco Man and Biosphere program. One ambition in
Sealings are an important part in the industrial robot. One important property of the seal is to keep all particles and fluids from the outside, away from the important components inside the robot. Another important property is to keep the oil and grease inside the robot, and prevent leakage. The seal also prevent leakage inside the industrial robot and reduces the risks of sensitive components to
The purpose of this thesis project was to analyse and evaluate different systems for installation of piperun in ceilings. Main focus lay on how the systems influence the installer from an ergonomic point of view as well as productivity in terms of installation time. Several studies have been performed during this project using a variety of methods such as observations, interviews, questionnaires a
Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX < 0.2 μg/mL and ADA development in a randomized setting. Metho
BACKGROUND: Periampullary cancer is a term for cancers arising in or in close proximity to the pancreas. Pancreatic cancer is the 3rd leading cause of cancer death for both sexes and while surgery is the only option for cure, chemotherapy is given in both the adjuvant and palliative settings. The aim of this study was to investigate any sex and gender differences in patients with pancreatic and ot
The nonionic low-osmolar contrast medium iohexol was used as marker of glomerular filtration rate (GFR) in 53 patients with stable renal function (group I: n = 32, group II: n = 21). All the patients had clearance values < or = 30 ml.min-1.1.73 m-2 body surface; 40 patients < 20 ml.min-1.1.73 m-2 body surface. Simultaneous determinations of renal clearance and plasma clearance, both as slope clear
The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR S
Per- and polyfluorinated alkyl substances (PFAS) are chemicals that have gained attention during the last years. There are about 10,000 different PFAS compounds, and due to their unique chemical characteristics, PFAS has been used in a variety of industrial applications and household products since the 1950s. Today, concerns about their toxicity and persistence have led to the regulation and banni
Introduction: Raspberries are cerebral microvascular formations of unknown origin, defined as three or more transversally sectioned vascular lumina surrounded by a common perivascular space. We have previously demonstrated an increased raspberry density in the cortex of patients with vascular dementia and cerebral atherosclerosis, while studies by other authors on overlapping and synonymously defi
BACKGROUND: The prevalence of teenage pregnancy in Colombia is higher than the worldwide average. The identification of socio-geographical disparities might help to prioritize public health interventions.AIM: To describe variation in the probability of teenage maternity across geopolitical departments and socio-geographical intersectional strata in Colombia.METHODS: A cross-sectional study based o
With the continued development of tracking technology and increasing interest in animal movement, our understanding of migration behavior has become more comprehensive. However, there are still many species that have not been well studied, particularly sea birds. Here, we present the first year-round Global Positioning System (GPS) tracking data of the Black-tailed Gull (Larus crassirostris) at th
Background Neighborhood deprivation has been found associated with both type 2 diabetes and lung cancer. The aim of this study was to examine the potential association between neighborhood deprivation and lung cancer incidence or mortality in individuals diagnosed with type 2 diabetes. The results may identify a new risk or prognostic factor for lung cancer in this important subgroup and help deve
Nasopharyngeal cancer (NPC) is a malignant tumor. In a recent publication, we described the presence and distribution of CD8+ T cells in NPC and used the information to identify ‘inflamed’, ‘immune-excluded’, and ‘desert’ immune phenotypes, where ‘inflamed’ and ‘immune-excluded’ NPCs were correlated with CD8 T cell infiltration and survival. Arguably, more detailed and, in particular, spatially re
Background and Aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods: The relationship betwee
Background: Tumour deposits are suggested to impact prognosis in colon cancer negatively. This study assessed the impact of tumour deposits on oncological outcomes.Methods: Data from the Swedish Colorectal Cancer Registry for patients who underwent R0 abdominal surgery for TNM stage I-III colon cancer between 2011 and 2014 with 5-year follow-up were analysed with multivariable analysis. Patients w
In this chapter, the pathophysiology and neurochemical pathology of epileptic brain damage is discussed on the basis of an integrative approach in which a comparison is made to cell necrosis resulting from ischemia and hypoglycemia. Two main questions are asked. First, is the brain damage resulting from these three disorders of cerebral energy metabolism similar in distribution and structural char
