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Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with ciclosporin, and assessment of MPA exposure is therefore necessary when reducing or stopping ciclosporin therapy. Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patie
Popular Abstract in Swedish Resultatet efter en höftprotesoperation är otvetydigt gott med smärtfrihet och god funktion ofta livet ut hos de flesta. 2012 opererades i Sverige cirka 16000 patienter med höftprotes och siffran stiger. 3-4% av patienterna drabbas av en proteslossning under de första tio åren och behöver opereras om, en så kallad revision. Den gamla protesen avlägsnas då och ersätts meThe clinical success of primary hip replacement is paramount but the need for revisions will continue to increase due to the increasing number of operated individuals. In Sweden, the number of hip revisions in 2012 exceeded 2,300. During implant loosening, some of the bone in the femur is lost, which can make the revision more difficult. One way of handling bone loss has been the impaction techniq
As current silicon-based microelectronic devices and circuits are approaching their fundamental limits, the research field of nanoelectronics is emerging worldwide. With this background, the present thesis focuses on semiconductor nanoelectronic devices based on ballistic and quantum effects.
The main material studied was a modulation doped In0.75Ga0.25As/InP semiconductor two-dimensional el
Popular Abstract in Swedish Helicobacter pylori är en spiralformad Gramnegativ human-specifik patogen, som kan penetrera magsäckens slemlager och kolonisera epitelskiktet. H. pylori infektion är en högriskfaktor för utvecklandet av kronisk gastrit, magsår och ventrikelcancer. Både aktivt växande spiralformer av H. pylori och dess runda viloformer framkallar kronisk magkatarr (gastrit) i BALB/cA möHelicobacter pylori is a human pathogen strongly associated with chronic type B gastritis, peptic ulcer disease, gastric cancer and MALT lymphoma. Our aims were to establish a mouse model of H. pylori infection, to study pathogenesis of gastritis and gastric cancer and to investigate new treatment strategies in this model. Both spiral and coccoid forms of H. pylori strains 17874, 25 and 553/93 cau
This dissertation deals with the morphological development in written L2 French by Swedish learners. The thesis presents a detailed analysis of number marking and agreement in NPs and VPs, focusing mainly on the production of the morphemes –s (in NP) and the third person plural –nt (in VP). These agreements are particularly interesting in French where number morphology is often silent in the oral
Background Despite high incidence of ankle fractures in the elderly, studies evaluating outcome and impact of quality of life in this age group specifically are sparse. The aim of this study was to evaluate outcome and quality of life 6 and 12 months after injury in patients 65 years or older who had been operated on due to an ankle fracture. Methods Sixty patients 65 years or older were invited
Background Sick leave due to neck, shoulder and back disorders (NSBD) is higher among health-care workers, especially nursing aides/assistant nurses, compared with employees in other occupations. More information is needed about predictors of sick leave among health care workers. The aim of the study was to assess whether self-reported factors related to health, work and leisure time could predict
Popular Abstract in Swedish Livskvalitet och problem i dagligt liv under och efter akut leukemi eller högmalignt lymfom - ett omvårdnadsperspektiv. Syftet med avhandlingen var att undersöka hur personer med akut leukemi eller hög- malignt lymfom upplevde och hanterade de problem som uppstod i det dagliga livet i samband med sjukdom och behandling och efter det att behandlingen avslutats. StudierThe aims of this thesis were, to investigate the impact on daily living of acute leukaemia or highly malignant lymphoma when under treatment, viewed retrospectively and from a longitudinal perspective, from the point of view of the patients and their spouses, and to ascertain their view of the nursing care provided. A combination of qualitative and quantitative methods was use i.e. open-ended inte
Popular Abstract in Swedish Syftet med den här studien är att undersöka utvecklingen av språkfärdigheten i skriftlig produktion av franska som främmande språk. Vi har följt 5 inlärares produktion av franska i en 30 månader lång longitudinell studie. För att kunna utvärdera färdigheten har vi använt oss av parametrarna flyt, komplexitet och korrekthet. Flyt och komplexitet har utvärderats med hjälpThe aim of this study is to examine the development of linguistic proficiency in written production of second-language French. In a longitudinal study of 30 months, we follow the written production of 5 guided learners of French as a second language. In order to apprehend proficiency we use the conventional parameters fluency, complexity and accuracy. The fluency and complexity are apprehended by
Wood is one of the oldest building materials, which have recently gained more focus in aneffort to reach net zero emissions. The mechanical properties of wood are dependent on the moisture content, and a high moisture content can also lead to biological attacks from decay fungi. To avoid biological attacks the wood must be protected from moisture, and a traditional method is to pressure impregnate
Denna rapport avser en stabilitetsanalys för att undersöka möjligheten att bygga en kupol i trä med en spännvidd på 300 meter. Alla lastbärande delar har modellerats med limträ av klassen GL30c och med dimensionerna 0.8×1.6 m2. Lastfallen valdes till 2 kN/m2 respektive 4 kN/m2 för symmetriska och asymmetriska snölaster. De numeriska beräkningarna utfördes i finita element-mjukvaran Abaqus FEA och The aim of this thesis is to study the feasibility of building a timber dome with a span of 300 metres, concerning elastic stability. The load-bearing members were modelled with the properties of glued laminated timber GL30c with the dimensions 0.8×1.6 m2. The design loads were 2 kN/m2 and 4 kN/m2 in symmetrical and asymmetrical load cases, respectively. The numerical calculations were performed u
Med hänvisning till den rådande resursbristen och till den ökade efterfrågan av vård i allmänhet och intensivvård i synnerhet är prioriteringsbeslut något som många vårdgivare måste befatta sig med dagligen. Under år 2020 när coronapandemin svepte över oss och belastade sjukvården ytterligare så blev frågeställningarna rörande prioriteringsbeslut ännu mer aktuella än innan. Socialstyrelsen släpptIn regard to the current shortage of resources and the increasing demand for care in general and intensive care in particular, priority decisions are something that many healthcare providers have to deal with on a daily basis. In 2020, as the Corona pandemic swept across us and further burdened the healthcare system, the issues surrounding priority decisions became even more relevant than before.
Leap-frog migration, i.e. when a northerly breeding population/species migrates further south compare to southerly breeding population/species, is a common migration pattern in birds. However, it is still unknown which factors facilitate the evolution of such a migration pattern pattern. A textbook example of a species exhibiting leap-frog migration is the Common Ringed Plover Charadrius hiaticula
To improve functional properties, 2 different types of egg albumen powder (high gel instant and ordinary) were hydrolyzed with four proteases (FPC, NPU, BAP and PSP) using different protease concentration (low, medium and high) at 50C for 1 h and subsequently polymerized by transglutaminase at 40C for 24 h. The enzymatic modified egg albumen was analyzed for foaming properties: foamability as %ove
Purpose: Real-time dynamic multileaf collimator (MLC) tracking for management of intrafraction tumor motion can be challenging for highly modulated beams, as the leaves need to travel far to adjust for target motion perpendicular to the leaf travel direction. The plan modulation can be reduced by using a leaf position constraint (LPC) that reduces the difference in the position of adjacent MLC lea
Background: To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods: Randomly recruite
Anthropogenic land-use change (LUC) substantially impacts climate dynamics, primarily through modifications in the surface biogeophysical (BGP) and biogeochemical (BGC) fluxes, which alter the exchange of energy, water, and carbon with the atmosphere. Despite the established significance of both the BGP and BGC effects, their relative contribution to climate change remains poorly quantified. In th
PURPOSE: To estimate the effect of dexamethasone eye drops on the risk of progression from type 2 retinopathy of prematurity (ROP) to ROP requiring traditional treatments.DESIGN: Register-based cohort study.PARTICIPANTS: Preterm infants born before 30 weeks' gestation from 2015-2018 (control years) and from 2020-2021 (intervention years) registered in the Swedish Quality Register for ROP at 4 Swed
Case endings are an important marker of fuṣḥā but are by most native speakers considered complicated and difficult. They typically appear only sporadically even in the most formal speech styles. There has been relatively little academic interest in the use of case endings in speech. Research has been characterized by largely impressionistic accounts (Badawi 1973, Meiseles 1977) and more recently b
Background: Women's fears and attitudes to childbirth may influence the maternity care they receive and the outcomes of birth. This study aimed to develop profiles of women according to their attitudes regarding birth and their levels of childbirth related fear. The association of these profiles with mode and outcomes of birth was explored.Methods: Prospective longitudinal cohort design with self
