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In the presence of ouabain (1 mM), acetylcholine and KCl (5 mM) evoked endothelium-independent relaxations in rat hepatic arteries. Treatment with capsaicin (10 μM), scopolamine (1 μM) or CGRP8-37 (3 μM) prevented these relaxations. Acetylcholine-induced relaxations in intact arterial segments in the presence of indomethacin (10 μM) and N(G)-nitro-L-arginine (0.3 mM) were only partially inhibited
The aim of this work is to develop a method for detection of brief episode paroxysmal atrial fibrillation (PAF). The proposed method utilizes four different features: RR interval irregularity, absence of P waves, presence of f-waves and noise level. The obtained features are applied to the Mamdani-type fuzzy inference method for decisionmaking. The performance was evaluated on one hundred 90 s lon
Nodularia spumigena is a toxic cyanobacteria that blooms in the Baltic Sea every year. In the brackish water of the Baltic Sea, its toxin, nodularin, mainly affects the biota in the surface water due to the natural buoyancy of this species. However, the fate of the toxin is unknown, once the cyanobacteria bloom enters the more saline waters of the Kattegat. In order to investigate this knowledge g
AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery.METHODS: Ninety-six patients scheduled for open
Importance: Accurate blood-based biomarkers for Alzheimer disease (AD) might improve the diagnostic accuracy in primary care, referrals to memory clinics, and screenings for AD trials. Objective: To examine the accuracy of plasma β-amyloid (Aβ) and tau measured using fully automated assays together with other blood-based biomarkers to detect cerebral Aβ. Design, Setting, and Participants: Two pros
Heart failure (HF) and cancer are common diseases among the elderly population. Many chronic diseases, including diabetes mellitus (DM), share risk factors and increase the incidence of HF and cancer. The aim of this study was to investigate if there was an association between HF and the prevalence of haematologic- and solid malignancies. Methods The study population was comprised of almost one mi
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
Background In randomized controlled trials of secondary prevention after stroke, the risk of hemorrhage varies between 1% and 5% per year in patients with antithrombotic therapy, i.e. anticoagulants and antiplatelets. Aim To explore the rate and the risk of hemorrhage after stroke in a nationwide cohort. Methods We identified 58 868 first ever ischemic stroke patients in the Swedish Stroke Registe
OBJECTIVE: To identify factors predicting response to first TNF blocking treatment course in patients with established RA with a special focus on gender differences. METHODS: Patients with active RA initiating their first treatment course of TNF-blocking therapy were enrolled. The study period was March 1999 through September 2006. The prospective protocol included information on demographics, cli
Land use/vegetation cover change, reflecting a range of human land use practices, is the most prevalent and immediate influence on alterations in soil quality. The physical structure of soil is crucial for safeguarding soil carbon (C) and nitrogen (N), as it modulates the physical protection mechanisms and the distribution of these elements within the soil. Nevertheless, the impact of soil physica
BACKGROUND: The assessment of the peritoneal membrane capacity and physiology of the individual patient is becoming increasingly important. It allows the prescription of an individualized peritoneal dialysis (PD)-regimen, and the monitoring of peritoneal membrane function over time. The PDC(TM) program offers the possibility to evaluate the peritoneal membrane characteristics and to predict solute
We celebrate Certec’s 20th birthday . . . . . . by giving you a book of 20 important ideas filled with pictures and text. Each idea is expressed in a succinct heading that sums up what we have learned over the years. The ideas also act as a complement to all the reports, website cover pages, brochures, lectures and annual reports. There are 30,000 documents at www.certec.lth.se that provide the
Popular Abstract in Swedish Utvärdering av stråldos och bildkvalitet i mammografi Bröstcancer är den cancerform som är vanligast hos kvinnor. Genom tidig upptäckt med bröströntgen, mammografi, kan man behandla sjukdomen i ett tidigare stadium och därmed minska dödligheten. Det är också möjligt att behandla på ett skonsammare sätt vid tidig upptäckt. Därför har man startat hälsokontroller, screeniMammography refers to the X-ray examination of the human breast, and is considered the single most important diagnostic tool in the early detection of breast cancer, which is by far the most common cancer among women. There is good evidence from clinical trials, that mammographic screening can reduce the breast cancer mortality with about 30%. The side effects include a small and age related risk
It is challenging for the food industry to deliver products that satisfy consumers changing desires and needs. Baobab is a fruit that holds potential for the development of trendy food products due to its rich nutritional profile and unique rheology. Unlike most fruits, it contains a dry pulp with a moisture content of 11-12 % (Phytotrade, 2008). Despite these features, baobab has been overlooked
Store-operated Ca2+ influx represents a major route by which cytosolic Ca2+ can be elevated during platelet activation, yet its molecular identity in this cell type remains highly controversial. Using quantitative RT-PCR analysis of candidate receptor-operated cation entry pathways in human platelets, we show a 30-fold higher expression of message for the recently discovered Orai1 store-operated C
In this paper the design and demonstration of a 7 nm(3) h(-1) integrated steam reforming based hydrogen production unit using a Fischer-Tropsch diesel is reported. The system design is discussed in detail, including the fuel processor itself as well as the hydrogen purification and results from stand-alone operation of the combined unit operations is reported. Further, the results of an integratio
Objective: The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI). Method: A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997-2001, (n = 344 127, elective caesarean section excluded). Medical reco
This study investigates the impact of a 10-week Arts on Prescription (AoP) program in Denmark designed for young adults aged 18–30 who were disengaged from education and unemployed. Eighteen participants took part in four semi-structured focus group interviews, and four completed a survey; most reported experiences of anxiety, depression, and stress, with some describing chronic pain, ADHD, or aut
Introduction: Suturing is a fundamental component of surgical procedures, wherein training emphasises the significance of gentle tissue handling. The suturing process involves the pressure exerted by the forceps onto the tissue, as well as the medial traction force applied to stabilise the tissue during the needle bite. This study examined the forces involved in tissue handling during suturing, co
“There is something to confess: your speaker likes to leave a movie theater. Back out on the more or less empty, more or less brightly lit sidewalk (it is invariably at night, and during the week, that he goes), and heading uncertainly for some café or other, he walks in silence (he doesn’t like discussing the film he’s just seen), a little dazed, wrapped up in himself…”In his 1975 essay, Leaving
