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Prenatal testosterone surge is considered crucial for physiological masculinization of male progeny. Disorders in sex steroid hormone balance during the fetal development may interfere with male reproductive health later in life. In this study, we have investigated in utero and in vitro effects of flutamide (FLU) and diethylstilbestrol (DES) on fetal rat testicular steroidogenesis. In utero exposu

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Cationic vinylpyridine based molecularly imprinted polymer monoliths were, for the first time, applied to enantiomer separation using capillary electrochromatography. In order to map the synthesis conditions under which superporous monoliths are obtained, capillary columns were prepared by an in situ polymerization technique using varying monomer and porogen compositions. Both electrolyte pH and p

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Questions: How does the number of species in a community affect the level of genetic diversity of its constituent species? What is the relation between competitive interactions and the spatial distribution of genetic variation? When spatially structured, how is the genetic differentiation among subpopulations affected by competition and size of the community? Model features and key assumptions: A

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Objectives: In industry-generated pivotal studies, lamotrigine has been found to be superior to placebo and comparable to lithium in the maintenance treatment of bipolar I disorder. Here, we directly compared lamotrigine to lithium under conditions similar to clinical routine conditions. Methods: Adult bipolar I disorder patients with at least two episodes within the last five years and an index e

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Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to

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Clinical techniques for early detection of acute hypotension during conventional hemodialysis treatment are lacking, even though intradialytic hypotension is the most common acute complication. In this article, intradialytic hypotension is identified by means of signal analysis of data recorded at two clinics. The database consists of 30 treatments with concurrently acquired signals: the 12-lead e

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Popular Abstract in Swedish Detta är en prospektiv longitudinell multicenterstudie som har haft som mål att utvärdera livskvaliteten (HRQL) hos patienter med cancer i huvudhalsregionen, vid diagnos, efter ett och fem år i relateration till tumörlokal, stadium, subsite, behand-ling, kön och ålder. Den första delen av studien, som varade i ett år, bestod av 357 patienter (medelålder 63 år; 72% män)The aim of this prospective longitudinal multicenter study was to evaluate the health-related quality of life (HRQL) in patients with head and neck cancer at diagnosis, after one and five years in relation to tumour location, stage, sub site, treatment modality, gender and age. The first part of the study, lasting for one year, consisted of 357 patients (mean age 63 years; 72% males) that were in

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Varumärkesrätten är territoriell, till skillnad från Internet, en av våra idag viktigaste marknadsplatser, som är globalt. Ett resultat av varumärkesrättens territorialitet och det faktum att rättigheterna till ett varumärke följer registrerings- eller inarbetningslandets gränser är att det är möjligt för ett varumärke att ägas av olika innehavare i olika länder. Vilket kan leda till problem när sTrademark law is territorial, contrary to one of today’s most important market places - the Internet, which is a global medium. Since the exclusive right to a trademark follows the boundaries of its country of registration or incorporation, it is possible for the same trademarks to be registered by different owners in different countries, something that can lead to problems on the Internet. The bo

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Studiens syfte var att psykometriskt utprova en svenskspråkig version av Hayling Test, ett neuropsykologiskt test som framför allt avser att mäta verbal inhibitionsförmåga. Testet utprovades på en frisk kontrollgrupp (N = 76) i åldern 40-95 år. Studien fann ett signifikant negativt samband mellan ålder och prestationer på testet. Män presterade signifikant bättre än kvinnor på ett av delmåtten. DeThe aim of this study was to examine the psychometric properties of an adapted Swedish version of the Hayling Test, a neuropsychological test which mainly intends to measure response inhibition. The test was administered to a healthy control group (N = 76) ranging in age from 40 to 95 years. The study found a significant negative correlation between age and test performance. Men performed signific

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The radiation exposure of fingers, thyroid and eyes of workers handling radiopharmaceuticals during various nuclear medicine procedures was measured using thermoluminescent dosemeters. Dosemeters were placed on the finger tips of 19 workers on several different occasions for various procedures. Additionally, the routinely determined whole-body doses to various groups of workers were analysed. The

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Popular Abstract in Danish Med udgangspunkt i et kompetenceudviklingsprojekt for lærere i en svensk kommune adresserer denne afhandling de stigende krav til forandring og innovation, der karakteriserer den offentlige sektor generelt. Ved at følge kompetenceudviklingsprojektet gennem en fire-årig periode sættes projektet i en kontekst af innovation, globalisering og forandring. Forfatteren argumentThis dissertation critically analyses the discourse on educational change. By placing educational change in the context of globalisation and innovation the author argues that the current discourse on educational change is un-nuanced and omits the important perspectives on change. The author has analysed an educational district in Sweden and one of its projects on competence development, named 'Str

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The overall aim of this thesis was to analyse the importance of co-morbidity level for different aspects of primary health care (PHC) using a measure of co-morbidity. Paper I examines whether there were differences in referral rates from different Lithuanian PHC models after adjustment for co-morbidity level. Paper II assesses to what extent the co-morbidity level could explain concurrent costs in

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Under which circumstances can the European Convention on Human Rights be applied to human rights violations perpetrated abroad by European military forces or other State agents? This question is highly relevant having in mind the European military presence in for example Iraq and Afghanistan. In contrast to the four Geneva Convention, applicable in armed conflict, the European Convention has a jur

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The halotolerant bacterial strain BU-4, isolated from a hypersaline environment, was identified as an exopolysaccharide (EPS) producer. Pretreatment liquids of steam-exploded quinoa stalks and enzymatic hydrolysates of Curupaú sawdust were evaluated as carbon sources for EPS production with the BU-4 strain, and the produced EPS was characterized using FTIR, TGA, and SEM. Cultivation was performed

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This chapter aims to discuss the phenomenon of altering the telos of a treaty by changing the focus of its object and purpose through treaty implementation. To examine the consequences in international law of altering the telos of a treaty, this contribution uses the example of the 2017 Treaty on the Prohibition of Nuclear Weapons (TPNW) against the backdrop of the considerations regarding a possi

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The research presented in this thesis is primarily focused on experimental investigations of laser-driven ion acceleration from solid targets via the target normal sheath acceleration mechanism. In particular, ways of optimizing the absorption of the laser pulse energy by free plasma electrons in the target, or modifying the shape of the accelerating electron sheath were addressed. The aim of this

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The healthcare environment may seem frightening and overwhelming in times when life-threatening conditions affect a family member or close friend and individuals visit the patient in an ICU. A two-bed patient room was refurbished to enhance the well-being of patients and their families according to the principles of evidence-based design (EBD). No prior research has used the Person-centred Climate

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Objectives. To clarify if an adaptive current stimulation protocol, in which current amplitude is modulated during continuous stimulation, provides better efficacy than constant current stimulation protocol with respect to analgesia caused by individualized stimulation in rat periaqueductal gray matter (PAG) /dorsal raphe nuclei (DRN). Approach. Ultrathin microelectrodes adapted for recording (n =

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Globins are usually associated with oxygen carriage in vertebrates. However, plants also contain similar heme-containing proteins, called phytoglobins (Pgbs). Unlike conventional hemoglobin, these proteins are often linked to nitric oxide metabolism, energy metabolism and redox maintenance under hypoxic and related abiotic and biotic stress conditions. Class I and II non-symbiotic Pgbs (nsPgbs) ha

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Discrepancies in views of the Self are suggested to be negatively related to well-being (Higgins, 1987). In the present study, we used a novel concept, Personality Estimation Discrepancy (PED), to test this classic idea. PED is defined as the computed difference between how one view oneself (Self-Perceived Personality) and a standard Big Five test (IPIP-NEO-30). In a pre-registered (osf.io) UK onl