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OBJECTIVE: Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).MATERIALS AND METHODS: This study was a randomized-controlled trial c
Aims In anticoagulation treatment with warfarin, the risk of thrombo-embolic events must be weighed against the risk of bleeding. Time in therapeutic range (TTR) is an important tool to assess the quality of anticoagulation treatment, and has been shown to correlate with less bleeding and thrombo-embolic complications. AuriculA, the Swedish national quality registry for atrial fibrillation and ant
OBJECTIVES: Under physiological conditions the blood flow velocity waveform in the umbilical vein (UV) has an even non-pulsating pattern. Pulsations in the UV have been described in human fetuses exposed to chronic hypoxia and heart failure. Current techniques for fetal surveillance during labor and delivery involve a risk of both over- and underestimation of fetal hypoxia. We aimed to examine whe
Objectives: In radiotherapy, delineation uncertainties are important as they contribute to systematic errors and can lead to geographical miss of the target. For margin computation, standard deviations (SDs) of all uncertainties must be included as SDs. The aim of this study was to quantify the interobserver delineation variation for stereotactic body radiotherapy (SBRT) of peripheral lung tumours
Objectives: Rituximab (RTX) is an anti-CD20 antibody that selectively depletes B cells and has emerged as a therapy for ANCA-associated vasculitis (AAV) during the past decade. This study sought to quantify and determine potential risk factors for severe infections in AAV patients treated with RTX at rheumatology clinics in Mexico City, Mexico and Lund, Sweden. Methods: The study consisted of a re
Permafrost regions contain approximately half of the carbon stored in land ecosystems and have warmed at least twice as much as any other biome. This warming has influenced vegetation activity, leading to changes in plant composition, physiology, and biomass storage in aboveground and belowground components, ultimately impacting ecosystem carbon balance. Yet, little is known about the causes and m
Läkartidningen 5-6/2025. Egenreferat. Dödshjälp, det vill säga eutanasi och läkarassisterat självmord, är olaglig i Sverige, men debatten om legalisering är fortsatt aktuell.Läkarförbundet genomförde 2021 en enkätundersökning om läkarkårens inställning till dödshjälp. 41 procent av de svarande ansåg att dödshjälp bör tillåtas enligt svensk lag (medan 34 procent motsatte sig detta), men endast 29 p
Recent years have seen a rise in extreme heat event (EHE)-related deaths in India. However, the impact of specific temperature thresholds on health risks remains understudied. Using Distributed Lag Non-Linear Models (DLNM), we explored the link between EHEs, defined by various temperature thresholds, and mortality risk in Ahmedabad, India, from 2002 to 2018, considering a 21-day lag. We observed a
Background and purpose — At our institution, new-borns with Barlow or Ortolani positive hips have been treated for 12 weeks with the von Rosen abduction splint until 2012 when the treatment length was halved. We inves-tigate whether acetabular development at 12 months of age and complications differ between hips treated with the von Rosen splint for 6 compared with 12 weeks. Patients and methods —
Background: In the laparoscopic Roux-en-Y gastric bypass procedure, the gastrojejunal stoma is constructed with either a circular (CSD) or a linear stapling device (LSD). The diameter of the stoma following stapling with the 21 mm CSD is expected to be approximately 12 mm (diameter of the anvil). Measuring the stoma diameter after linear stapling is a little more complex since the remaining openin
BACKGROUND: The elapsed time taken to diagnose tumors of the central nervous system in children and adolescents varies widely. The aim of the present study was to investigate such diagnostic time intervals at a national level in Sweden as they correlate with clinical features.METHODS: Data prospectively accumulated over a 4-year period in the Swedish Childhood Cancer Registry from patients aged 0-
High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein
Ovarian cancer is the most lethal gynecological malignancy, with treatment heavily relying on platinum-based chemotherapy. However, resistance frequently develops, posing a major clinical challenge that underscores the need for new approaches. In this study, we investigated the phosphoproteomic landscape underlying cisplatin resistance, which remains poorly understood. A parental CAOV3 ovarian can
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
Background: Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug-related harms. Methods: We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO). We assessed the frequency of PIM, untreated conditions (medication and vaccination under
Familial risks for cancer are important for clinical counseling and understanding cancer etiology. Medically verified data on familial risks have not been available for all types of cancer. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0-to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Cancer cases were retrieved from
The purpose of this investigation was to describe the clinical spectrum of invasive Fusobacterium necrophorum infections and Lemièrre's syndrome, to examine the role of underlying thrombophilia and concomitant mononucleosis in Lemièrre's syndrome, and to describe thromboembolic complications. Patients with invasive F. necrophorum infections were identified either prospectively or retrospectively t
To maintain stability in the Swedish electricity grid, Svenska kraftnät must be able to predict future electricity production and consumption. Earlier this have been done by using historical data. Now the complexity of the system has increased, because the growing amount of electricity from nondispatchable sources as well as the impact of climate change. Thus using only historical data will give
Aims: To assess lung function at early school age in children delivered at very early gestation owing to intrauterine growth restriction and abnormal foetal blood flow (IUGR). Methods: Spirometry was performed at median age 8.4 (range 6.5-10.7) years in 31 children born preterm with IUGR (PT-IUGR) with a median (range) birth weight (BW) of 650 (395-976) g and median (range) gestational age 27 (24
Checklista för uppdragsavtal Forskningsservice Sophie Hydén Picasso Finansieringsmetoder för excellens PLANERA EN AKADEMISK KARRIÄR En akademisk karriär är ofta mångfacetterad, och dess olika delar ställer krav på olika typer av egenskaper och färdigheter. Olika karriärprofiler och vägar framåt kan överlappa och kombineras, alternativt så rör man sig mer etappvis längst karriärvägen. Forskning, un
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/finansieringsmetoder-for-excellens.pdf - 2026-07-11
