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Electroconvulsive therapy (ECT) is effective and safe for adults with severe depression, but less studied in adolescents. Here, we examined the indications, prevalence, practice, response and remission rates, and side effects in young people treated with ECT in Sweden. We also examined the usage of ECT in the transition to adult psychiatry. Using data from national patient registers and the Swedis
Purpose: Hematoma volume is the strongest predictor of patient outcome after intracerebral hemorrhage (ICH). The aim of this study was to validate novel fully automated software for quantification of ICH volume on non-contrast computed tomography (CT). Methods: The population was defined from the Swedish Stroke Register (RS) and included all patients with an ICH diagnosis during 2016–2019 in Regio
Quantum annealing is a promising approach for obtaining good approximate solutions to difficult optimization problems. Folding a protein sequence into its minimum-energy structure represents such a problem. For testing new algorithms and technologies for this task, the minimal lattice-based [hydrophobic (H) or polar (P) beads] HP model is well suited, as it represents a considerable challenge desp
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and cell death in cartilage are among the first signs
Background: Sexual dysfunction is common following a cancer diagnosis in young adulthood (18–39 years) and problems related to sex life are ranked among the core concerns in this age group. Yet, few studies have investigated to what extent adults younger than 40, receive information from healthcare providers about the potential impact of cancer and its treatment on their sex life. Methods: A popul
Background: The growing use of digital primary care consultations has led to concerns about resource use, equity and quality. One of these is how it affects antibiotic prescription. Differences in ease of access for patients and available diagnostic information for the prescribing physicians are reasons to believe prescription rates may be affected. Objectives: We estimated differences in antibiot
BackgroundSymptom severity cutoffs for body dysmorphic disorder (BDD) are lacking, hindering communication between professionals and with the patient community.MethodWe pooled data from 11 clinical trials or high-quality cohort studies from specialist clinics, totaling 804 individuals with BDD (80 % girls/women, 67 % adults). All participants had baseline scores on the adult or adolescent versions
Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through
Objectives (1) To assess the risk of haematological malignancies in individuals with systemic sclerosis (SSc) compared with individuals without SSc; (2) to explore how the risk varies across groups stratified by sex and age; and (3) to determine when these malignancies present in relation to SSc diagnosis in a population-based setting. Methods We performed a nationwide cohort study using high-qual
Background: Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but the benefits and risks in survivors of intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs reduce the risk of ischaemic stroke without substantially increasing the risk of recurrent intracerebral haemorrhage. Methods: PRESTIGE-AF is a multicentre, open
Executive Summary Butterflies have been systematically monitored in Europe for several decades using standard protocols that are now adopted in over 30 countries. Butterflies are ideal biological indicators: they are well-documented, measurable, sensitive to environmental change, occur in a wide range of habitat types, represent many other insects, and are popular with the public because of their
Introduction: The Swedish Sleep Apnea Registry (SESAR) collects clinical data from individual obstructive sleep apnea (OSA) patients since 2010. SESAR has recently been integrated with additional national healthcare data. The current analysis presents the SESAR structure and representative clinical data of a national sleep apnea cohort. Methods: Clinical data from unselected patients with a diagno
OBJECTIVE: Determine whether there is a relationship between the number of different lower-limb resistance exercises prescribed in a program and outcomes for people with knee osteoarthritis.METHODS: Systematic review with meta-regression. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase up to 4th January 2024. We included randomised controlled trials th
Neuroendocrine tumours (NETs) of the small intestine (siNET) are slow-growing malignancies often diagnosed at an advanced stage. Despite their indolent nature, patients frequently experience significant symptoms, including carcinoid syndrome (CS) with diarrhoea, which impact their health-related quality of life (HRQoL). This thesis investigates the determinants of HRQoL in siNET patients, its prog
Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp
Aim of the review: This review aimed to evaluate the impact of Point-of-care Ultrasound during cardio- pulmonary resuscitation for adult non-traumatic CA on clinical outcomes and survival.Data sources: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed and Embase databases were searched on 14 November 2022. The
Thesis purpose: to develop theory that can explain the contradictions that we see in contemporary society in the choice of cooking salt. Salt consumption can cause severe health problems. Consumers in the middle and upper classes are health aware, but seem to have other motivations for their choice in cooking salt. As appears in the hype that we see around cooking salt and the increased specialisa
This study aims to investigate the possibility of creating template times for rail works. Furthermore the study identifies a few effects which template times could have on planning of rail works, traffic and economy. Template times are being considered by the Swedish Transport Administration, Trafikverket, for the early stages of planning when there is a need to estimate the time required within t
Syftet med denna text är dels att kunna beskriva och förklara anledningen till förändringen i Welles estetik från debutfilmen Citizen Kane (1941) till hans återkomst till USA med Touch of Evil (1958) dels att redogöra för hur den berättarstruktur som utmärkte hans debutfilm förekom i flera av hans produktioner. Jag skall särskilt behandla uppkomsten av filmen Mr. Arkadin/-Confidential Report; och
Background: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). DGE causes prolonged hospital stay and a decrease in quality of life. This study analyzes predictive factors for development of DGE after PD, also in the absence of surgical complications. Method: Data from the Swedish National Pancreatic Cancer Registry for patients undergoing standard and pyloru
