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Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized therapeutic options. We studied the translational significance of liquid biopsy in a uniformly treated trial cohort. Pretreatment circulating tumor DNA (ctDNA) revealed hidden clinical and biological heterogeneity,

We show that weakly entangled states can improve communication over a qubit channel using only separate, interference-free, measurements of individual photons. We introduce a communication task corresponding to the cryptographic primitive known as secret sharing and show that all steerable two-qubit isotropic states provide a quantum advantage in the success rate using only product measurements. F

Previous investigations of aqueous based ethyl cellulose (EC) latex dispersions have mainly focused on the commercially available viscosity grade 20 cps. In this study, dispersions of EC with varying viscosity grades (which correspond to molecular weights), ranging from 4 to 100 cps, were produced and characterised. The dispersions showed particle sizes around 200 nm and highly negative ζ-potentia

Mot bakgrund av brottsutvecklingen mot rättsväsendet de senaste åren har begreppet otillåten påverkan fått en mer framträdande roll. Syftet med denna uppsats är att undersöka och utreda om problematiseringen kring begreppet otillåten påverkan samt ge förslag hur gällande rätt bör se ut. Begreppet otillåten påverkan är i sig inte ett brott i straffrättslig mening men omfattar ett flertal påverkansfThe concept unlawful influence has been given a more prominent role as a result of the recent development of crime against the judicial system. The purpose with this thesis is to analyse the concept unlawful influence and propose a suggestion on what the applicable law should be in this area. The concept itself is not a criminalized act and it covers several types of influences. However it is undi

Syfte: Det övergripande syftet med uppsatsen är att undersöka vad som förklarar förändringen i företags framtida utdelning. Mer specifikt ämnas undersöka om en förändring i kreditbetyg påverkar ett företags nästkommande års utdelning, samt om tidigare observerade samband och teorier håller på den europeiska marknaden. Metod: Denna kvantitativa studie har en explorativ inriktning med deduk-tiv anPurpose: The main purpose of this thesis is to examine what explains cor-porations’ future dividend change. More explicit this thesis in-tends to examine the effects of a change in credit rating as well as examine if previously observed relationships holds on the Euro-pean market. Methodology: This quantitative study has an explorative orientation with a de-ductive approach. Secondary cross-sect

Denna uppsats utreder institutet förundersökningsbegränsning och dess tillämpning utifrån ett rättssäkerhetsperspektiv. Förundersökningsbegränsning utgör ett av undantagen från den annars rådande förundersökningsplikten och innebär en långtgående möjlighet att i vissa fall lägga ned eller välja att inte inleda en förundersökning. Institutet är ett resultat av processekonomiska överväganden och kanThis paper investigates the institute of preliminary investigation limitation and its application from the perspective of the rule of law. This limitation constitutes one of the exceptions from the otherwise prevailing obligation for pre-trial investigation and amounts to a far-reaching possibility to close down or choose not to initiate preliminary investigation. This institute results from proce

Soft power and public diplomacy compose the new reality shaping the dynamics of contemporary international relations. Strategic narratives represent an essential means for political actors to extend their influence, gain the public opinion’s support for their actions and fulfill their foreign policy goals. The thesis focused on the Chinese Party state’s construction of strategic narratives targete

The study aims to investigate the behavior of vulnerable road users at tramway crossings along the new tramway in Lund. The purpose is to find connections between potentially risky behaviors and the tramway crossings’ design and regulation. Furthermore, the study examines the functionality of the crossings and the reasons behind the chosen design and regulation. The studied crossings are located a

The purpose of this essay was to contribute to an increased understanding about battered women. We also wanted to find patterns and explanations as to why the women acted as they did. The questions asked were: - Why didn't the women leave the men after the first abuse? - Why did the women accept the abuse? - What makes the women choose the same kind of men over and over again? "Love on wh

The purpose for this study was to see if Swedish handicap policy is living up to the goal too give disabled women full citizenship. Handicap policy is studied from outcomes of the decisions from the Swedish law of help and service for some disabled (LSS) and from the socially law (SoL) during year 2000 in Staffanstorp community. The main question is; How's the welfare for disabled women? The m

Återupptagen hävd på Kungsmarken Kungsmarken, strax utanför Lund, är ett område som brukats under väldigt lång tid, åtminstone sedan 1200-talet och betraktas som ett av Sveriges finaste botaniska områden. Området, som numera är både naturreservat och Natura 2000-område, delas i nordost-sydvästlig riktning av en stenmur. Norr om muren betade djur och söder om den slogs marken med lie för vinterfodHay meadows are becoming scarce in the Swedish agricultural landscape and restoration efforts are crucial to not lose the rich biodiversity. I studied three closely situated areas, one formerly grazed and the other two mown for at least 800 years, which had been left for free succession for more than fifty years. The purpose of my study was to investigate the outcome two years after restoration st

Virtual reality är framtiden. Nya tekniker utvecklas konstant och parallellt med att datakapaciteten förbättras finner vi nya sätt att använda dem ihop. Vi har utvecklat ett nytt interaktivt visualiserings verktyg (Molecular Rift) som låter användaren uppleva molekylära modeller i en virtuell verklighet. I dagens medicinindustri är man i ständigt behov av nya metoder för att visualisera potentiellVisualization of molecular models is a vital part in modern drug design. Improved visualization methods increases the conceptual understanding and enables faster and better decision making. The introduction of virtual reality goggles such as Oculus Rift has introduced new opportunities for the capabilities of such visualisations. A new interactive visualization tool (MolecularRift), which lets t

Innovation is a popular concept among organizational researchers, all of whom tend to share a common consensus that it is highly important for organizational effectiveness. Furthermore, whether theoretically or conceptually presented, innovation has been widely described and argued as something which organizations can control and manage with a view to increase their levels of competitiveness. Howe

In situ Fourier transform infrared spectroscopy was used to study transient CO oxidation over a series of bimetallic Pd-Pt catalysts with different Pd:Pt molar ratios. The catalysts were found to contain both alloyed PdPt nanoparticles (particle sizes 25-35 nm) and monometallic Pd nanoparticles (sizes below 10 nm). For oxygen-free conditions, CO reduces the surface while simultaneously function as

Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate t

This study analysed demand for 12 metals in global climate mitigation scenarios up to 2060 and quantified the impacts on demand of different assumptions on improvements and technological mix. Annual and cumulative demands were compared with reserves and current mining rates. The study results showed that reserves are sufficient to support the total level of solar power, wind power and electric mot

Release of halide ions is an essential step of the catalytic cycle of haloalkane dehalogenases. Here we describe experimentally and computationally the process of release of a halide anion from the buried active site of the haloalkane dehalogenase LinB. Using stopped-flow fluorescence analysis and umbrella sampling free energy calculations, we show that the anion binding is ion-specific and follow

We present 77 new granite whole-rock analyses from the Qattar and Gharib areas, Eastern Desert, Egypt. Both areas include a “normal” granite and either a hypersolvus (Gharib) or an almost plagioclase-free granite (Qattar) enriched in fluorite. According to earlier results, F influences element distribution in granitic melts forming complexes with specific elements as Nb, Ta, Ga, Hf, Th, Zn, Sn, w

BACKGROUND: Cleaning workers are exposed to chemicals and high physical workload, commonly resulting in airway problems and pain. In this study the response in the upper airways and the physical workload following airborne and ergonomic exposure of cleaning spray was investigated.METHODS: A survey was answered by professional cleaning workers to investigate their use of cleaning sprays and the per

This study investigates the toxic effect of E(2)nonenal (trans-2-nonenal, T2N) and its conjugate with horse muscle myoglobin (Mb) tested on murine cell line L929 and human cell line A549, as well as the genotoxic effect of these compounds assayed by measuring of micronuclei in human cells K562. It is an aldehyde, which is occurring as the substance responsible for an off flavour in aged beers, but