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One of the outstanding challenges presented by liquid water is to understand how molecules can move on a picosecond time scale despite being incorporated in a three-dimensional network of relatively strong H-bonds. This challenge is exacerbated in the supercooled state, where the dramatic slowing down of structural dynamics is reminiscent of the, equally poorly understood, generic behavior of liqu

Background. The development of fluid and salt retention is a potential problem for all peritoneal dialysis (PD) patients. Sodium removal by the peritoneum is predominantly determined by convective fluid loss but influenced by diffusion and sieving due to free water transport as predicted by the three-pore model (TPM). The aim of the study was to establish the effect of transport status, dwell leng

Given the rapidly increasing number of women above 50 it is of pivotal importance to consider health issues related to gonadal hormone deficiency. The possibility of alleviating such symptoms by hormone replacement therapy (HRT) should be recognized by all physicians, not merely by gynaecologists. But which women should be given what therapy, and for how long? Due to the increased risk of endometr

Popular Abstract in Swedish Syftet med den här avhandlingen har varit att studera association och växelverkan mellan proteiner och polymerer. Två olika tekniker har använts i dessa studier; datorsimuleringar och fördelning i polymera vattenhaltiga tvåfassystem. Vikten av att studera protein-polymer-växelverkan ligger i att flera biotekniska, och medicinska tillämpningar baserar sig just på proteiThe aim of this thesis has been to study protein-polymer interaction and association. Two different techniques were used; Monte Carlo simulations were combined with partitioning in polymeric aqueous two-phase systems. Monte Carlo simulations have been used to evaluate the hydrophobic interaction in electrolyte solution. The results showed that monovalent salt only slightly increases the hydrophob

Bandwidth efficiency is a key objective in the design of a digital communication system. Traditionally it is accomplished by increasing the constellation size of the signaling system. In this thesis alternative techniques are studied. Because the communication channel is continuous, so must the actual time signals be. Therefore the construction of the continuous signals is included in the code des

OBJECTIVES: To evaluate effects of postmenopausal hormone replacement therapy (HRT) on von Willebrand factor, factor (F)VIII, factor (F)VII, fibrinogen, antithrombin (AT) III, prothrombin fragments 1 and 2, protein C, total and free protein S, plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and resistance to activated protein C. DESIGN: Part 1: double blind randomized

Baobab fruit pulp (Adansonia digitata) is a nutrient rich fruit, native to Africa. The physicochemical property of baobab pulp was studied in order use baobab emulsions to formulate prototype for functional food beverage. The physicochemical properties that were studied by dispersing baobab pulp by two methods - by dispersing the whole fruit with water and by dispersing the baobab powder with wate

The winter of 2020 was dominated by Canadian and international news coverage about a group of indigenous land defenders in Northern British Columbia, Canada. At the centre of the media frenzy was a pipeline conflict involving an indigenous community, namely, the Wet’suwet’en Nation, and Canada’s largest private sector investment ever which is set to cross directly through Wet’suwet’en territory. T

Individspecifik bildanalys och beräkningsmodell av läkande hälsena Hälsenan är den största senan i kroppen och hälseneruptur är en av de vanligaste sen- skadorna. Efter en ruptur läker senan med en ärrad vävnad och återfår inte sin intakta struktur. Detta innebär en stor risk för att hälsenan inte återfår sin funktion. I dagsläget brister kunskapen om vilken behandlings-metod som återställer hälsAchilles tendon rupture is becoming more prevalent with an increasing population of middle aged people participating in recreational sports. A torn Achilles tendon will likely not regain its original function, and it is unknown what treatment options are optimal. The Achilles tendon structure and how the tendon heals after a rupture varies between humans. A potentially useful tool in understanding

Cold deformation of metals is known to induce roughness on their free surface. In some of the processing equipment of Tetra Pak processing systems, tubes of austenitic stainless steel 316L are used. During the production of this processing equipment, such tubes are occasionally cold-deformed. In this work, surface and microstructure characterization of alloying type 316L austenitic stainless steel

Background: Recent knowledge in animals suggests that gut microbial metabolism may affect host metabolism, including appetite regulating hormones. The aim of the present study was to evaluate the potential effects of a whole grain barley kernel product, rich in intrinsic indigestible carbohydrates (dietary fibre and resistant starch), on markers of metabolism and appetite regulation in healthy sub

Abdominal sepsis is associated with changes in systemic inflammation response and coagulation homeostasis. Excessive neutrophil activation is a key regulator in both pro-inflammatory immune response and septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to invading pathogens. To examine the role of neutrophil extracellular traps for septic lung injury and systemic

BACKGROUND: Cancer stem cells (CSCs) have been invoked in resistance, recurrence and metastasis of cancer. Consequently, curative cancer treatments may be contingent on CSC selective approaches. Of particular interest in this respect is the ionophore salinomycin, a natural product shown to be 100-fold more active against CSCs than clinically used paclitaxel. We have previously reported that synth

Elbehovet ökar och landbaserad solkraft lyfts fram som en lösning för att snabbt möta elektrifieringen, men när solparker planeras på jordbruksmark väcks debatten: mat eller el? En möjlig väg framåt är att upprätta solparker på lågproduktiv jordbruksmark och förvalta den som gräsmark för att främja kolinlagring. I den planerade solparken Kogshult, i Sjöbo kommun, undersöker denna studie solsambruk

Den 2 juli 2014 infördes lagändringar om bygglovsbefriade åtgärder i syfte att förenkla plan- och bygglovsprocessen, minska bostadsbristen och att fastighetsägare skulle få mer handlingsutrymme utan att krav ställs från myndigheter. I samband med lagändringarna infördes regler om bygglovsbefriade komplementbostadshus i 9 kap. 4 a § PBL. En byggnad som får utgöra maximalt 25 kvadratmeter och som sk

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated cells. Overexpression of EZH2 has been found in several cancer types such as breast, prostate, melano

The global aviation industry is experiencing growing pressure to decarbonize, driving significant demand for Sustainable Aviation Fuel (SAF). Second-generation feedstocks that do not directly compete with food crops, such as lipid oils from insects and lignin-derived oils, are promising sources, but their high concentrations of inorganic contaminants and oxygen make them incompatible with existing

BACKGROUND: Nitrones such as 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) are known to trap and stabilize free radicals and to reduce inflammation. Recently, S-PBN was shown to reduce infiltration of T lymphocytes and the expression of adhesion molecules on the endothelium in experimental traumatic brain injury. We hypothesized that S-PBN could reduce infiltration of T lymphocytes during cell-media

Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and

Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t