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Growth hormone (GH) has insulin-antagonistic effects, and GH secretion is augmented during fasting and hypoglycemia. In the present study, 10 patients aged 21 to 28 years with childhood-onset GH deficiency (GHD) were studied during a 24-hour fast and a hypoglycemic glucose clamp before and after 9 months of GH replacement. During the 24-hour fast, blood glucose, serum insulin, and serum free fatty

The objectives of the present study were to estimate long-term risks of osteoporotic fractures. The incidence of hip, distal forearm, proximal humerus and vertebral fracture were obtained from patient records in Malmo, Sweden. Vertebral fractures were confined to those coming to clinical attention, either as an inpatient or an outpatient case. Patient records were examined to exclude individuals w

Few epidemiologic studies have examined the hypothesis that circulating androgens are involved in the development of ovarian cancer. We investigated the association between prediagnostic serum levels of androgens and sex hormone–binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One hundred

BACKGROUND: High concentrations of lithium in drinking water were previously discovered in the Argentinean Andes Mountains. Lithium is used worldwide for treatment of bipolar disorder and treatment-resistant depression. One known side effect is altered thyroid function. OBJECTIVES: We assessed associations between exposure to lithium from drinking water and other environmental sources and thyroid

OBJECTIVE: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours. MATERIALS AND METHODS: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of

The gene encoding calpain-10 (CAPN10) has been identified as a candidate gene for type 2 diabetes. Our aim was to study the impact of genetic (heritability and polymorphisms) and nongenetic (insulin, free fatty acids, and age) factors on CAPN10 mRNA expression in skeletal muscle using two different study designs. Muscle biopsies were obtained before and after hyperinsulinemic-euglycemic clamps fro

We used stochastic dynamic programming to investigate a spectacular migration strategy in the black brant Branta bernicla nigricans, a species of goose. Black brant migration is well suited for theoretical analysis since there are a number of existing strategies that easily can be compared. In early autumn, almost the entire population of the black brant gathers at Izembek Lagoon on the Alaska Pen

Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below the age of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorour

The report deals with the problems which may be caused by internal additional insulation of an existing building component. Problems treated in this report are heat losses through and surface condensation at thermal bridges, condensation in the building components, stresses due to temperature and moisture content variations and possibly frost damage in facade materials. After internal insulation

AIMS: To assess the effect of metformin on insulin sensitivity, glucose tolerance and components of the metabolic syndrome in patients with impaired glucose tolerance (IGT). METHODS: Forty first-degree relatives of patients with Type 2 diabetes fulfilling WHO criteria for IGT and participating in the Botnia study in Finland were randomized to treatment with either metformin 500 mg b.i.d. or placeb

Popular Abstract in Swedish Hårdvara och algoritmer för ett inbyggt videoövervakningssystem presenteras i denna avhandling. För att verifiera systemet så har en prototyp byggts.The demands on video surveillance systems are rapidly increasing regarding parameters such as frame rate and resolution. Furthermore, with an ever increasing number of video streams, an automated process for extracting relevant information is required. Due to the large amount of input data and the computational complexity of the algorithms, software implementations are not sufficient to sustain re

Integrated development environments (IDEs) increase programmer productivity, providing rapid, interactive feedback based on the syntax and semantics of a language. A heavy burden lies on developers of new languages to provide adequate IDE support. Code generation techniques provide a viable, efficient approach to semi-automatically produce IDE plugins. Key components for the realization of plugins

This dissertation focuses on aspects of the social context of child and adult eyewitness memory reports, along with their relation to report accuracy and metamemory performance. More specifically, it investigates the effects on memory reports and metamemory judgments of i) receiving feedback from co-witnesses, ii) being probed for further eventmemory reports, and iii) retelling eventmemory content

This thesis demonstrates the potential of the liquid membrane extraction technique as an alternative method for the analysis of trace ionisable organic compounds in the environment. Liquid membrane based extraction methods for the analysis of s-triazine herbicides and phenolic compounds were developed. Selectivity of the technique was demonstrated by extraction the above compounds in river water,

This acoustofluidics tutorial focuses on continuous flow-based half wavelength resonator systems operated in the transversal mode, where the direction of the primary acoustic force acts in plane with the microchip. The transversal actuation mode facilitates integration with up- and downstream microchannel networks as well as visual control of the acoustic focusing experiment. Applications of parti

In this study the structured laser illumination planar imaging (SLIPI) technique is combined with gas phase phosphor thermometry to measure quasi-instantaneously two-dimensional temperature fields with reduced bias from multiple scattering. Different reconstruction strategies are implemented, evaluated and compared, including a two-pulse and one-pulse SLIPI approach. A gradient-based threshold alg

Aims: The aim of this study was to compare the cancer morbidity in a large cohort of patients with alcohol use disorders in the general Danish population. Methods: We included 15,258 men and 3552 women free of cancer when attending the Copenhagen Outpatient Clinic for Alcoholics in the period from 1954 to 1992. The cancer incidence until 1999 of the patients and the general Danish population was o

Ammonia (NH3) is regarded as one of the most viable alternatives to produce carbon-free energy. However, its low flammability and high NOx emissions associated with its combustion inhibit the implementation of pure NH3 as a fuel. Dual-fuel approaches with NH3 and more reactive fuels have been proposed; however, information on pollutant emissions is still scarce. The present work focuses on quantif

Significantresearch efforts are currently directed towards the synthesis and studies of durable anion exchange membranes (AEMs) with the aim to develop alkaline fuel cells and electrolyzers able to operate efficiently without platinum-groupmetal catalysts [1]. The grand challenge is to identify and synthesize polymeric AEM materials possessingthe necessary chemical and thermal stability. Studies o