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Various new prognostic indicators have been identified for mammary carcinomas, but the issue of their significance remains unsettled. The prognostic impact of p53, c-erbB-2, and topoisomerase II alpha expression was investigated in relation to standard prognostic factors for carcinomas of the breast and to the tumour cell growth fraction. Paraffin-embedded specimens of 356 node-negative infiltrati

The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects

Purpose: To determine how image quality linked to tumor detection is affected by reducing the absorbed dose to 50% and 30% of the clinical levels represented by an average glandular dose (AGD) level of 1.3 mGy for a standard breast according to European guidelines. Materials and methods: 90 normal, unprocessed images were acquired from the screening department using a full-field digital mammograph

The aim of the study was to characterize the relationship between the pharmacolkinetics of methotrexate in serum and concentrations in the cerebrospinal fluid, and to analyse the association to risk of a central nervous system relapse in children with acute lymphoblastic leukaemia. In this retrospective study, 353 children with acute lymphoblastic leukaemia treated with high-dose methotrexate acco

Popular Abstract in Swedish EG-fördragets regler om varors fria rörlighet är ett centralt område inom de Europeiska gemenskapernas rättsordning. Detta rättsområdet har stor betydelse i det praktiska rättslivet, såväl för offentlig förvaltning som för enskilda företag. I denna bok behandlas spörsmål rörande EG-fördragets regler om icke-tariffära handelshinder (artiklarna 30, 34 och 36). Ända sedanThis thesis concerns the Articles 30, 34 and 36 of the EC-Treaty and conflicts of competence between the Community and the Member States. It deals especially with the delimitation between community concerns and national concerns in the field of non-tariff barriers to trade in community law. A new perspective concerning the application of Articles 30 and 34 of the EC-Treaty is introduced. It is arg

OBJECTIVE: to analyse the impact of stent-graft (SG) design and operator skill on the outcome of endovascular AAA repair. DESIGN: prospective non-randomised open. MATERIAL: a total of 158 patients (mean age 71) underwent SG repair. Patients were treated with five different types of SG: first (n =58) and second ( n =17) generation Ivancev-Malmo monoiliac SG (IM I and IM II respectively) combined wi

BACKGROUND: Anisakis simplex (A.s.) allergy is an emerging disease. The third-stage larvae of this nematode are a source of hidden allergens in fish. There are no clear guidelines concerning dietary restrictions for patients with serum-specific IgE to this parasite. OBJECTIVE: To follow up the clinical data and immunological parameters of patients sensitized to A.s. during 6 to 23 months. METHODS:

Understanding the dynamics of ligands bound to proteins is an important task in medicinal chemistry and drug design. However, the dominant technique for determining protein-ligand structures, X-ray crystallography, does not fully account for dynamics and cannot accurately describe the movements of ligands in protein binding sites. In this article, an alternative method, ensemble refinement, is use

Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent a

Optical wireless networks realized by means of gigabit optical wireless communication (OWC) systems are becoming, in a variety of applications, an important alternative, or a complementary solution, to their fiber-based counterparts. However, performance of the OWC systems can be considerably degraded in periods of unfavorable weather conditions, such as heavy fog, which temporarily reduce the eff

Liquid hydrogen is a promising energy carrier due to its excellent performance. However, liquid hydrogen sloshing usually causes serious issues on its safety production, storage, transportation, application and management. To study fluid sloshing in cryogenic storage tanks, a numerical calculation model is developed with considerations of the environmental heat leakage and phase change occurring a

Although there are many technological solutions and policy approaches for transitioning to a fossil-free society, effective action is still lacking. We need a new way to address the issue, one that inspires and attracts the widest possible group of society. Against this background, the aim of this paper is to explore citizens' political agency in influencing transport policy, and the inner and out

Internationella dataöverföringar stödjer den globala ekonomin, underlättar internationellt samarbete och främjar ekonomisk expansion. Denna ökade produktivitet innehåller dock risker, nämligen stora risker för kränkningar av den personliga integriteten. I en tid som domineras av tekniska framsteg har regeringar, inom EU och i tredjeländer, potential att överträda individers integritet på en nära gInternational data transfers serve to support the global economy, facilitating international collaboration and economic expansion. However this increased productivity comes at a cost, namely amplified personal data privacy and security risks. In an era dominated by rapid technological advancements, the clandestine actions of intelligence agencies have the potential to infringe upon the privacy and

EU:s nya klimattull: Tanken är god – men verkligheten krångligare År 2026 införs EU:s nya klimattull, CBAM. Tullen ska förhindra att utsläppsintensiv industri flyttar från EU till följd av högre klimatkostnader inom unionen. Målet är att stärka europeisk konkurrenskraft och minska globala utsläpp. Men denna studie, som undersökt CBAM:s påverkan på nordiska företag, visar att mekanismen i sin nuva

As the population ages, the risk of loneliness increases,especially when reduced mobility or illness leads to isolation from community and social life. At the same time 7 percent of Danes live with major disabilities, yet the built environment often overlooks their needs. Age and disability alike reveal how architecture continues to fall short of true inclusion. This thesis is an experiment in r

Lunds Universitetssjukhus är det största sjukhuset i Skåne. Sjukhuset närmar sig 100 år och behöver moderniseras och därför kommer en omplacering av sjukhusområdet att göras omkring år 2040. Denna studie undersöker svagheter och möjligheter för kollektivtrafik till det nya sjukhusområdet för att kunna möta behovet av kollektivtrafik år 2040. Studien bygger på en litteraturstudie tillsammans med enThis study examines the challenges and opportunities for public transport to meet the future demand for Lund University Hospital which will be reloacted in 2040. Based on a survey targeting on employees at the current hospital (N=780), the result reveals that employees younger than 40 are driving as much as the group above 65, while the age group between 40 and 65 is mostly using either public tra

With the sustainable potential of the city as a starting point, this thesis examines brownfield redevelopment in an existing urban context. The Nørrebro neighborhood of Copenhagen serves as a case. The focus is on learning from and reinterpreting existing urban structure, hierarchy, density and scale. Legislation allowing car free development at the chosen site, Vingelodden, also prompts explorati

We introduce a novel unsteady shear protocol, which we name rotary shear (RS), where the flow and vorticity directions are continuously rotated around the velocity-gradient direction by imposing two out-of-phase oscillatory shears (OSs) in orthogonal directions. We perform numerical simulations of dense suspensions of rigid non-Brownian spherical particles at volume fractions between 0.40 and 0.55

Biomarkers for evaluating response to neoadjuvant chemotherapy (NACT) in ER+/HER2- breast cancer remain limited. This study explores the impact of NACT on tumor proliferation dynamics and its association with relapse-free interval (RFI) among 175 patients with early ER+/HER2- breast tumors. Proliferation was assessed at baseline, after completing two NACT cycles, and in the residual tumor using Ki