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Popular Abstract in Swedish Kroniskt Obstruktiv Lungsjukdom (KOL) är idag världens fjärde vanligaste dödsorsak vars dödlighetsfrekvens ökar. KOL är en lungsjukdom som nästan alltid beror på rökning och i hela världen är cirka 600 miljoner människor drabbade av sjukdomen. Detta gör KOL till världens vanligaste kroniska sjukdom. I Sverige beräknas sjukvårdskostnaderna för KOL att uppgå till ca 9,1 mProteomic analysis of bronchoalveolar lavage (BAL) fluid from smokers at risk of developing chronic obstructive pulmonary disease (COPD) and never smokers is described. COPD is currently the world's fourth leading cause of death and its prevalence is increasing. The leading cause of COPD is smoking and an estimated 600 million people in the world suffer from COPD which makes it the world's most co

Intracellular lipolysis is a major pathway of lipid metabolism that has roles, not only in the provision of free fatty acids as energy substrate, but also in intracellular signal transduction. The latter is likely to be particularly important in the regulation of insulin secretion from islet beta-cells. The mechanisms by which lipolysis is regulated in different tissues is, therefore, of considera

Liver plays a key role in the metabolism of plasma apolipoproteins, endogenous lipids and lipoproteins. Hepatocellular carcinoma (HCC) is one of the most common fatal malignant tumors in China and in other Southeast Asian countries. This has been attributed to the high incidence of hepatitis B infection. Hepatitis B proteins, such as the hepatitis B X protein (HBx) that is large hepatitis B surfac

Liquid hydrogen is a promising energy carrier due to its excellent performance. However, liquid hydrogen sloshing usually causes serious issues on its safety production, storage, transportation, application and management. To study fluid sloshing in cryogenic storage tanks, a numerical calculation model is developed with considerations of the environmental heat leakage and phase change occurring a

Although there are many technological solutions and policy approaches for transitioning to a fossil-free society, effective action is still lacking. We need a new way to address the issue, one that inspires and attracts the widest possible group of society. Against this background, the aim of this paper is to explore citizens' political agency in influencing transport policy, and the inner and out

Purpose: WST11 vascular targeted photodynamic therapy (VTP) is a local ablation approach relying upon rapid, free radical-mediated destruction of tumor vasculature. A phase III trial showed that VTP significantly reduced disease progression when compared with active surveillance in patients with low-risk prostate cancer. The aim of this study was to identify a druggable pathway that could be combi

Internationella dataöverföringar stödjer den globala ekonomin, underlättar internationellt samarbete och främjar ekonomisk expansion. Denna ökade produktivitet innehåller dock risker, nämligen stora risker för kränkningar av den personliga integriteten. I en tid som domineras av tekniska framsteg har regeringar, inom EU och i tredjeländer, potential att överträda individers integritet på en nära gInternational data transfers serve to support the global economy, facilitating international collaboration and economic expansion. However this increased productivity comes at a cost, namely amplified personal data privacy and security risks. In an era dominated by rapid technological advancements, the clandestine actions of intelligence agencies have the potential to infringe upon the privacy and

EU:s nya klimattull: Tanken är god – men verkligheten krångligare År 2026 införs EU:s nya klimattull, CBAM. Tullen ska förhindra att utsläppsintensiv industri flyttar från EU till följd av högre klimatkostnader inom unionen. Målet är att stärka europeisk konkurrenskraft och minska globala utsläpp. Men denna studie, som undersökt CBAM:s påverkan på nordiska företag, visar att mekanismen i sin nuva

Lunds Universitetssjukhus är det största sjukhuset i Skåne. Sjukhuset närmar sig 100 år och behöver moderniseras och därför kommer en omplacering av sjukhusområdet att göras omkring år 2040. Denna studie undersöker svagheter och möjligheter för kollektivtrafik till det nya sjukhusområdet för att kunna möta behovet av kollektivtrafik år 2040. Studien bygger på en litteraturstudie tillsammans med enThis study examines the challenges and opportunities for public transport to meet the future demand for Lund University Hospital which will be reloacted in 2040. Based on a survey targeting on employees at the current hospital (N=780), the result reveals that employees younger than 40 are driving as much as the group above 65, while the age group between 40 and 65 is mostly using either public tra

With the sustainable potential of the city as a starting point, this thesis examines brownfield redevelopment in an existing urban context. The Nørrebro neighborhood of Copenhagen serves as a case. The focus is on learning from and reinterpreting existing urban structure, hierarchy, density and scale. Legislation allowing car free development at the chosen site, Vingelodden, also prompts explorati

We introduce a novel unsteady shear protocol, which we name rotary shear (RS), where the flow and vorticity directions are continuously rotated around the velocity-gradient direction by imposing two out-of-phase oscillatory shears (OSs) in orthogonal directions. We perform numerical simulations of dense suspensions of rigid non-Brownian spherical particles at volume fractions between 0.40 and 0.55

Biomarkers for evaluating response to neoadjuvant chemotherapy (NACT) in ER+/HER2- breast cancer remain limited. This study explores the impact of NACT on tumor proliferation dynamics and its association with relapse-free interval (RFI) among 175 patients with early ER+/HER2- breast tumors. Proliferation was assessed at baseline, after completing two NACT cycles, and in the residual tumor using Ki

Breakthroughs in battery research are imperative to provide society with batteries that are safe and sustainable, have a high energy density, and have a long cycle life at low cost. Recent advances in research methodologies, the emergence of new market opportunities, and strategic funding schemes have allowed not only large, but also small companies, universities, and public research organizations

Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator-like proteins 2 and 3 (NPRL2, and NPRL3) genes, which encode the components of GTPase activating protein Activity Toward Rags Complex 1 (GATOR1) complex. Evero

Acoustophoresis enables label-free separation of particles and cells in microfluidic sys- tems, but systematic methods for analysing and comparing separation behaviour re- main limited. In this thesis, a workflow based on the mobility ratio was evaluated as an experimental framework for characterising acoustophoretic separations, using flow cytometry as the analytical tool. Separation experiments

Collective action problems emerge when individual incentives and group interests are misaligned, as in the case of climate change. Individuals involved in these problems are generally considered to have two options: contribute toward public solutions such as global warming mitigation or free ride. However, many collective action problems today involve a third option of investing in a “private solu

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial lipopolysaccharide (LPS), a driver of hyperinflammation in severe COVID-19. How viral evolution over the years alters this interaction remains unclear. Here, we i

Purpose: Evaluating performance of modern dose calculation algorithms in SBRT and locally advanced lung cancer radiotherapy in free breathing (FB) and deep inspiration breath hold (DIBH). Methods: For 17 patients with early stage and 17 with locally advanced lung cancer, a plan in FB and in DIBH were generated with Anisotropic Analytical Algorithm (AAA). Plans for early stage were 3D-conformal SBR