Filtyp
OBJECTIVE:: The severity of vasomotor symptoms has been hypothesized to be linked to a lower bone mineral density (BMD). We examined whether women with vasomotor symptoms are different from women without symptoms with regard to BMD. DESIGN:: We used data from a population-based sample of 5,600 women, aged 46 to 57 years and free from bone diseases, who participated in the first cross-sectional par
Popular Abstract in Swedish I över 40 år har det varit möjligt att operera förslitning (artros) av höftleden med en konstgjord led. De allra flesta av de cirka 12 000 patienter, som opereras i Sverige varje år med så kallad höftplastik, får en ny höftkula av metall och en ny ledpanna av plast. De nya leddelarna förankras oftast i lårbenet (kulan) respektive bäckenbenet (pannan) med bencement, ett 144 consecutive hip revisions performed with morselized allograft bone and cement were followed up to 5 years after surgery. In 49 hips patient outcome was evaluated with the Nottingham Health Profile (NHP) questionnaire and Charnley hip scores in 47 hips prosthetic fixation was evaluated with radiostereometry (RSA)and in all 144 hips risks and complications were recorded using a prspective protoc
This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis.Paper II illustrates that, in rare cases, low-level s
Background Previous trials of interferon in multiple sclerosis (MS) have shown efficacy, but the degree of clinical benefit remains uncertain, and the optimum dose is not known. We undertook a double-blind, placebo-controlled study in relapsing/remitting MS to investigate the effects of subcutaneous interferon -1a. Methods 560 patients with Kurtzke expanded disability status scale (EDSS) scores of
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. Tissue microarrays derived from two cohorts of patients with breast cancer (n=122 and n=498) were immunostained, revealing varying expression of COMP, both in the tumor cells and surrounding stroma. High levels of COMP in tumor cells correlated, independently of
In optical DNA mapping technologies sequence-specific intensity variations (DNA barcodes) along stretched and stained DNA molecules are produced. These "fingerprints" of the underlying DNA sequence have a resolution of the order one kilobasepairs and the stretching of the DNA molecules are performed by surface adsorption or nano-channel setups. A postprocessing challenge for nano-channel based met
We use Monte Carlo simulations of a coarse-grained model to investigate structure and electrochemical behaviours at an electrode immersed in room temperature ionic liquids (RTILs). The simple RTIL model, which we denote the asymmetric restricted primitive model (ARPM), is composed of monovalent hard-sphere ions, all of the same size, in which the charge is asymmetrically placed. Not only the hard-
Enabling techniques for separating target cells, such as subgroups of white blood cells and cancercells from blood and other body fluids, are necessary for lab work facilitation, inline integration withhigh-end bioanalytical instrumentation, and for point-of-care or home testing. The work of this thesisaddresses this need by further studying an equilibrium-based ultrasonic wave-based technology ca
In radiotherapy (RT), the treatment is thoroughly planned and optimized to fulfil the goal of delivering a high dose to the target, while sparing as much normal tissue as possible. This implies that the patient position and anatomy should be the same as they were during the planning image acquisition. To achieve this, it is important to have motion management methods for predicting, monitoring, an
Background: Traditional risk factors for atherosclerotic disease (AD) are well-known, of which some are relevant also for abdominal aortic aneurysms (AAA). The present study compares the importance of plasma biomarkers and traditional risk factor profiles for incident AD without concomitant AAA (isolated AD) and AAA without concomitant AD (isolated AAA) during long-term follow-up. Methods: In the
OBJECTIVE: To investigate the associations between incipient dementia (ID) and hospitalization for ambulatory care sensitive conditions (ACSCs) among people with osteoarthritis (OA) of the peripheral joints.METHODS: Among individuals aged 51-99 years residing in Skåne, Sweden, in 2009, we identified those with a doctor-diagnosed OA and no dementia during 1998-2009 (n = 57,733). Treating ID as a
Abstract Objective: To evaluate the long-term outcome of men with an initial prostate-specific antigen (PSA) level below 3 ng/mL and whether the free-to-total (F/T PSA) ratio is a useful prognostic marker in this range. Materials and methods: This study is based on 5,174 men aged 50–66 years, who in 1995–1996 participated in the first round of the Göteborg randomized screening trial (initial T-PSA
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration-resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivation therapy (ADT) may play a role in PCa progression is unknown. In this study, we examined the inhibitory effect of tamoxifen on castration-resistant PCa in vitro
BackgroundA novel non-invasive method for generation of pressure volume loops (PV-loops) using brachial blood pressure and cardiovascular magnetic resonance (CMR) imaging has recently been presented and validated (1). The non-invasive nature of this method enables calculation of PV-loops in large patient cohorts previously not feasible due to the need of invasive measurements.PurposeThe purpose of
This master thesis is a study of how three public libraries in Scania approach refugees in 2015: Helsingborg, Lund and Malmö’s public library. The Swedish Library Act states that public libraries should be available to and usable by all people. The purpose of this research is to find out to which degree public libraries have the possibilities to fulfill this Act, in terms of their organizational s
Det är inte förrän på senare tid som brottsoffrets intressen och behov uppmärksammats i den samhälleliga, politiska och juridiska debatten. I samband med det viktimologiska perspektivets genomslag har medvetenheten ökat kring att våldsutsatta brottsoffer inte bara drabbas av direkta fysiska skador, utan också ingripande psykiska sådana. Detta har i sin tur bidragit till en skärpt syn på allvarligaInterests and needs of victims of crime have not until recently been a focus of societal, political or legal debate. As the victimological perspective gained impact, the awareness has likewise increased concerning violent crimes and their extensive psychological effects on victims. This, in turn, has contributed to an increased societal condemnation of serious violent crimes. The essay intend to
Med hjälp av den rättsdogmatiska metoden kan det konstateras att en tilltalad är skyddad av den s.k. oskyldighetspresumtionen. Det innebär att bevisbördan ligger hos åklagaren och att den tilltalade ska betraktas som oskyldig till dess att motsatsen är bevisad. Den tilltalade har därmed en rätt att vara tyst under hela förfarandet. Den tilltalades tystnad, lögner och icke trovärdiga förklaringar fBy studying the current legal situation using mainly the traditional legal method, it can be established that the presumption of innocence protects the defendant. That means the defendant should be considered innocent until proven guilty, that the burden of proof lies with the prosecution and that the defendant has a right to remain silent throughout the criminal procedure. If the defendant remain
Denna uppsats utreder hur finansiella produkter klassificeras i inkomstslaget kapital, och vilka skatterättsliga skillnader som finns mellan de olika kategorierna i inkomstslaget. Utifrån praxis och inkomstskattelagens systematik redogörs för hur en avyttring av kryptovalutan Bitcoin ska klassificeras och beskattas. Gällande rätt analyseras sedan mot bakgrund av principen om likformighet och skattThis paper examines how financial products are classified within the capital gains bracket and which tax differences follow from such classification. Based on practice and the methodology of the Income tax act, the paper describes how a divestment of the cryptocurrency Bitcoin should be classified and taxed. The result is thereafter analyzed from the perspective of the principle of uniformity and
Kvävereningen på Svedala avloppsreningsverk har under perioder varit ansträngd och Svedala kommun frågade sig därför vad som kunde göras för att förbättra kvävereningen så att kvävereningskravet på 10 mg/l kväve klaras till 2030 då ytterligare 3000 personer förväntas vara anslutna. En utredning startades därför för att identifiera vad som begränsar kvävereningen samt lösningar för att förbättra kvThe nitrogen effluent at Svedala wastewater treatment plant has under periods been high, and the municipality of Svedala therefore wanted to know what could be done to improve the nitrogen removal, so that the nitrogen effluent limit of 10 mg/l could be managed until 2030, when another 3000 persons are expected to be connected to the wastewater treatment plant. An investigation was therefore start
Laglottssystemet i Sverige har under lång tid varit ifrågasatt och kritiserat. Under de senaste åren har flera motioner kommit med förslag att laglotten ska utredas på nytt. Syftet med denna uppsats är att undersöka hur sociala normer och värderingar har en rättsbildande påverkan på arvsrätten. De delar av laglotten som undersöks är äganderätten och lika arvsrätt för bröstarvingar. Uppsatsen är beThe statutory share of inheritance in Swedish Law gives a direct heir the right to retain half of the estate in heritage. The other half is the deceased allowed to dispose through a will. The statutory share of inheritance has been under criticism for a long time and up for debate in both media and parliament. The purpose of this essay is to examine how social norms and values influence legislat
