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The content of this thesis consists of two parts. For the first part, size and crystallographic orientational influence on the elastic properties of bcc nanowires and films have been studied through static molecular simulations. In order to explicitly account for surface effects, the concept of surface free energy has been employed. Comparisons between continuum mechanical calculations and results
In this work, we present a stroboscopic detection technique for the study of oscillating nanoscale objects. This optical read-out gives a position accuracy better than 1 nm which is a fraction of both the diffraction limit and the pixel size. The advantage of this stroboscopic method compared to conventional time-averaging techniques, is the time-resolution it provides as well as being non-invasiv
It has been demonstrated that prostate-specific antigen (PSA), in spite of its name, can be detected in body fluids and tumors from a variety of organs. Investigations have shown that human glandular kallikrein 2 (hK2), a related prostate-secreted protease, can activate the zymogen form of PSA, suggesting that the two enzymes might work as a functional unit, with hK2 as the activator molecule and
Providing increased transmission speed, quality and an efficient spectrum utilization is crucial for high speed wireless services of today and the future. This thesis is a collection of papers that address an important step in that direction -- the utilization of the spatial domain of the wireless channel. Paper I provides a survey of the most important concepts in channel and radio propagation m
This thesis consists of a collection of essays on coordination in games and competition in international oligopolies. The first essay presents a theoretical analysis of a simple coordination game in which players simultaneously choose efforts from a compact interval. The original game has a continuum of Pareto-ranked equilibria. In a noisy variant of the model an error term is added to each player
Interstitial laser thermotherapy (ILT) is an attractive form of local therapy against cancer because of its anti-tumor immune activity. The aim of this work was to evaluate ILT in breast cancer with respect to technique, changes in tissue immunocompetent cells and effect on prognosis. The method is dependent on accurate assessment of the tumor, and another aim was therefore to evaluate if MRI is b
Popular Abstract in Swedish Cystisk fibros (CF) är en ärftlig sjukdom som orsakas av en defekt jonkanal. Denna defekt ger upphov till en onormal saltbalans i kroppen och följderna blir många. I lungorna och magtarmkanalen produceras ett väldigt segt slem vilket täpper till luftvägarna och medför andningssvårigheter. De slemfyllda lungorna klarar inte av att transportera upp slemmet och istället stCystic fibrosis is an inherited disease, caused by mutations of the cystic fibrosis transmembrane conductance regulator gene. The gene codes for a protein that serve as chloride channel. In cystic fibrosis, this protein is lacking or has a defect function resulting in a thick and sticky mucus of the airways. The altered airway environment promotes mucus and growth of pathogenic bacteria. A common
Introduction: Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. Methods: In total, 126 breast tumor tissue specimens including 32 samples from patients carry
Popular Abstract in Swedish Denna avhandling behandlar tillväxt av och elektriska mätningar på halvledande nanotrådar av indiumarsenid (InAs) och kombinationer av InAs och indiumfosfid (InP). En nanotråd är som namnet antyder en tunn solid tråd, som påminner om ett hårstrå fast med en diameter på typiskt 50 nm (en nanometer är en miljarddels meter, 10^-9 m) och längden kan vara allt från 100 nm upIn this thesis, semiconductor nanowires are studied from the point of view of growth and electrical properties. The growth of nanowires is done by chemical beam epitaxy (CBE), an ultra-high vacuum technique allowing a precise control of precursor deposition and low growth rates. In conventional epitaxy, growth is usually two or three- dimensional, depending on growth conditions and material combin
All cellular organisms in aquatic environments are susceptible to virus attack. Viruses are the smallest but most abundant biological entities in freshwaters. This thesis describes interactions between viruses and bacteria in temperate and polar freshwaters with particular emphasis on Arctic and Antarctic aquatic systems. Free virus-like particles in freshwaters are vulnerable and exposed and as p
Milk is a dilute aqueous dispersion with a complex mixture of proteins, fat, carbohydrates, vitamins and minerals. Milk membrane lipids are a part of the milk fat globule membrane (MFGM), which covers the fat globules. During dairy processing membrane material is released and surface structure features are altered. The presence of free membrane material as well as various surfaces might influence
In the present work amphiphilic graft copolymers were prepared by free radical copolymerization of macromonomers in solution. The graft copolymers consisted of methacrylate backbones bearing ethylene oxide (EO)n side chains of varying length as ionophilic groups, and fluorocarbon (CF2)6 side chains or hydrocarbon groups as ionophobic groups. Homogenous polymer gel electrolytes were prepared by add
Popular Abstract in Swedish Partiklar som finns i luften och som vi andas in kan leda till negativa hälsoeffekter bland oss människor. I varje andetag andas vi in tusentals partiklar som tar sig ner i våra luftvägar. Det är normalt. Våra kroppar har försvarsmekanismer som tar hand om och oskadliggör partiklar som vi andas in och som fastnar i våra andningsvägar. Vid för höga halter av partiklar i BACKGROUND: Exposure to airborne particles in occupational environments can lead to both acute and long-term health effects in humans. To date, particle exposure limits in the air are typically given in terms of mass concentrations. But by only using mass concentration to characterize particles means there is a risk that other relevant characteristics, such as particle size and composition are con
Att ta reda på hur och varför reaktioner sker molekyler emellan är ingen lätt uppgift. Ingen kamera är tillräckligt liten eller känslig (än) för att filma det som händer på molekylnivå. Istället behöver forskare genomföra experiment och samla stora mängder data för att få en bild av hur en reaktion går till, den så kallade reaktionsmekanismen. Att ta reda på reaktionsmekansimer ökar förståelsen föN-Acetylneuraminic acid (Neu5Ac) is the most common form of sialic acid, a nine-carbon sugar often situated at the ends of glycoconjugates. Its unique reactivity makes it a complex substrate to work on, but new methods are continuously developed. In 2007, Ye et.al. reported a regioselective substitution by morpholine on position 4 of fully acetylated Neu5Ac, with retained stereochemistry. The anom
Denna uppsats undersöker hur rörelsedata från hälsoapplikationer presenteras och värderas som bevis i svenska brottmål samt vilka rättssäkerhetsmässiga utmaningar som är förknippade med denna typ av digital bevisning. Uppsatsen inleds med en genomgång av de processrättsliga ramar som styr bevisprövningen i brottmål, med särskilt fokus på principen om fri bevisprövning. Därefter presenteras rörelseThis thesis examines how motion data from health applications is presented and evaluated as evidence in Swedish criminal trials, as well as the legal safeguards and challenges associated with this type of digital evidence. It begins with an overview of the procedural rules governing the assessment of evidence in criminal proceedings, with particular focus on the principle of free evaluation of evi
This master’s thesis deals with commercialisation strategies for entrepreneurial firms. The basis of the work is a framework of investigation that incorporates a company’s internal and external factors, crucial when determining an appropriate strategy. This framework of investigation is applied on the case company Layerlab. Layerlab is an entrepreneurial company in the biotech industry, aiming at
Konsten att flyga har uppstått fyra gånger under evolutionens gång: hos fåglarna, fladdermössen, insekterna och de nu utdöda flygödlorna. En av dessa grupper – insekterna – har varit otroligt framgångsrik: insekter står för ungefär 80% av världens arter. Troligtvis har förmågan att flyga bidragit till deras framgång. Men trots att det finns många fördelar med att kunna flyga – man kan till exempel fly frAerodynamic theory states that the power required to fly is related to flight speed with a ∪-shaped curve. This has been shown in vertebrates, but insects have been proposed to have a flat, or J-shaped power curve. This means that hovering – flying at zero speed – is energy-efficient, which would explain why it is a relatively common flight mode in insects. In this thesis I show that some insects do, in
Background: Even though identical blood group matching between recipient and donor is preferred, it is still not clear by how much this improves the outcome for patients who received a lung transplant (LTx), or whether there is any survival benefit. Earlier studies have yielded ambiguous results and few have investigated long-term survival. The aim of this study is, therefore, to explore the diffe
Background: Mitral valve (MV) and tricuspid valve (TV) apparatus geometry are essential to define mechanisms and etiologies of regurgitation and to inform surgical or transcatheter interventions. Given the increasing use of cardiovascular magnetic resonance (CMR) for the evaluation of valvular heart disease, we aimed to establish CMR-derived age- and sex-specific reference values for mitral annula
