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The incidence of prostate cancer has increased dramatically during the last 10-15 years and it is now the commonest cancer in males in developed countries. The increase is mainly caused by the increasing use of opportunistic screening or case-finding based on the use of prostate-specific antigen (PSA) testing in serum. With this approach, prostate cancer is detected 5-10 years before giving rise t
The co-assembly of DNA and lipids has broad implications, from the structure of the cell nucleus to gene delivery formulations. To progress in the fundamental understanding of DNA-lipid interactions the self-assembly behavior of a cationic surfactant (dodecyltrimethylammonium, DTA) with DNA as a counterion in mixtures of water and lecithin was investigated. The phase diagram was established and th
The methanolic extract of Sesbania sesban Merrill (Fabaceae) raw seed materials contained total free phenolic content of 14.56 +/- 1.11 g catechin equivalent/100 g extract dry matter (DM). Encouraging levels of reducing power (FRAP, 1068 mmol Fe[II]/mg extract), inhibition of beta-carotene bleaching (49.80%) and scavenging activity against DPPH (51.65%) as well as superoxide (44.87%) radicals were
Isometric force, glycogen phosphorylase activity and lactate production were measured under conditions known to alter intracellular Ca2+ and cAMP to assess the role of these messengers in the coordination of metabolism with contractility in rat portal vein. Total phosphorylase (a + b) activity, was independent of treatment. The activity ratio phosphorylase activity ratio in the presence of isoprot
Popular Abstract in Swedish Den elektriska aktiviteten i hjärtats förmak vid kroniskt förmaksflimmer Bakgrund: Det mänskliga hjärtmuskeln består av fyra delar som var och en omsluter ett hålrum, vänster och höger förmak samt vänster och höger kammare. Ett hjärtslag, dvs den sammandragning av hjärtmuskeln som pumpar runt blodet i kroppen, utlöses normalt av att en elektrisk impuls bildas i sinuskChronic atrial fibrillation (CAF), with a prevalence progressively increasing with age, is one of the most common cardiac arrhythmias in man and associated with increased morbidity and mortality. Previous studies have shown that, in animals as well as in man, experimental atrial fibrillation is based on different types and dimensions of intra-atrial electrical re-entry. However, there is a lack of
BACKGROUND: Recent studies have suggested that reactive oxygen species may be involved in the development of diabetic retinopathy. METHODS: Nitro blue tetrazolium (NBT) staining, a marker of reductants which may be induced by free radicals such as superoxide, and catalase activity, as an indirect measure of hydrogen peroxide (H2O2) generation, were studied in the rat retina in three conditions kno
Background: Scavenger receptor BI (SR-BI) is a classic high-density lipoprotein (HDL) receptor, which mediates selective lipid uptake from HDL cholesterol esters (HDL-C). Apolipoprotein M (ApoM), as a component of HDL particles, could influence preβ-HDL formation and cholesterol efflux. The aim of this study was to determine whether SR-BI deficiency influenced the expression of ApoM. Methods: Bloo
Within the software industry it is now common to use the freemium business model; giving away the core product for free while charging for additional premium features. A risk for companies adopting the freemium business model is that the percentage of paying customers is not high enough to both subsidize all the free users and make profit for the company. This thesis investigates how the design o
I detta examensarbete studeras inverkan av pH på konformationsprocesserna i enzym FKBP12 med hjälp av kärnmagnetisk resonansspektroskopi (NMR). Tidigare studier har identifierat två konformationsprocesser i FKBP12, där den mindre befolkade konformationen i den snabbare processen misstänks vara en intermediär konformation mellan konformationerna som deltar i den långsammare processen. I projektet gThis master thesis project reports the dependence on pH of the conformational exchange in the enzyme FKBP12. Previous NMR studies have identified two conformational exchange processes in FKBP12, where the faster process is believed to be an exchange to an intermediate state between the more slowly exchanging conformations. In this project I carried out different NMR experiments across the pH-inte
Amyloida fibriller är aggregat av självassocierande proteiner som tillsammans skapar ett tätpackat inre med hög ordningsgrad. Dessa fibriller är ofta förknippade med neurodegenerativa sjukdomar, t.ex. Alzheimers- och Parkinsons sjukdom. I dagsläget saknas botemedel för dessa sjukdomar och därav finns det intresse för att studera amyloida fibriller. Grundläggande forskning om exempelvis fibrillernaAmyloid fibrils are aggregates of self-assembled peptides and proteins that forms a highly ordered and densely packed core of β-strands stacking perpendicular to the length of the fibril. Amyloid fibrils of the protein α-synuclein (α-syn) are associated with Parkinson’s disease. This study aims at contributing to the physiochemical basis of α-synuclein aggregation and dissolution, mainly in terms
Handledningsaritmetik Managing the politics of value creation – The case of waste management services Hervé Corvellec & Johan Hultman Department for service management Lund University Value in Service Management Service dominant logic has revived debate on value creation in services Emphasises shortcomings of value-in exchange view Co-creation of value e.g., Grönroos’ view that service provider an
https://www.ses.lu.se/sites/ses.lu.se/files/corvellec_servsig_2012_value_social_construct.ppt - 2026-05-03
This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lea
Prostate-specific antigen (PSA) is a kallikrein-like serine protease mainly expressed in the human prostate. It is responsible for the proteolysis of the gel-forming proteins in human semen. Two major extracellular protease inhibitors, alpha-1-antichymotrypsin (ACT) and alpha-2-macroglobulin (AMG) may inactivate PSA escaping from the prostate. The predominant immunodetected form of PSA in serum is
What are the main challenges for fossil-free agriculture and food systems, according to Swedish farmers? And what do farmers think fossil-free farms should look like, and how should they function? What actions are needed from different actors to achieve these visions by 2050? These questions were discussed during a lunch-to-lunch workshop in Eskilstuna, 13-14 November 2025. The purpose of the work
Neural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3-20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that events preceding actual tissue implantation and during the first week thereafter are crucial, and that apoptosis plays a pivotal role. Triggers t
Aim: To determine the prevalence of neurobehavioral symptoms at 6.5 years in children born extremely preterm (EPT, <27 weeks' gestation). Methods: Population-based cohort study of infants born EPT in Sweden from 2004 to 2007. Of 486 survivors 375 were assessed and compared with 369 matched term-born controls. EPT children free from neurosensory and intellectual disabilities (neurodevelopmental dis
Background: Although sugar consumption has been associated with several risk factors for cardiometabolic diseases, evidence for harmful long-term effects is lacking. In addition, most studies have focused on sugar-sweetened beverages (SSBs), not sugar per se. Objective: The aim of this study was to examine the associations between added and free sugar intake, intake of different sugar sources, a
