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Djävulens advokat eller kritiskt tänkande – En jämförelse mellan två metoder för underrättelseanalys och deras relevans som för undvikande av partisk analys

Denna uppsats behandlar de två analysmetoderna djävulens advokat och kritiskt tänkande och dess relevans för att undvika partisk analys. Genom en jämförelse av de två metoderna är avsikten att klargöra likheter och skillnader och om det är två olika metoder eller om de inte bara är variationer på samma tema. Vidare är avsikten att beskriva hur väl de två metoderna bidrar till bättre underrättelseaThis paper deals with the two analytical methods devil's advocate and critical thinking and its relevance to avoid biased analysis. Through a comparison of the two methods its intention is to clarify the similarities and differences, and whether there are two different methods or only variations on the same theme. The purpose is to describe how well the two methods contributes to better intell

Microenvironment profiling of high-grade serous ovarian cancer

Ovarian cancer is among the most lethal gynecological malignancies, with high-grade serous ovarian cancer (HGSOC) being the most aggressive and prevalent subtype. This heterogeneous disease is typically diagnosed at an advanced stage and is associated with high relapse rates. Increasing attention is being directed toward the tumor microenvironment (TME), a complex and dynamic network of non-cancer

Molecular crowding impacts the structure of apolipoprotein A-I with potential implications on in vivo metabolism and function

The effect molecular crowding, defined as the volume exclusion exerted by one soluble inert molecule upon another soluble molecule, has on the structure and self-interaction of lipid-free apoA-I were explored. The influence of molecular crowding on lipid-free apoA-I oligomerization and internal dynamics has been analyzed using electron paramagnetic resonance (EPR) spectroscopy measurements of nitr

Dynamic changes in the functional anatomy of the human brain during recall of abstract designs related to practice

In the present PET study we explore some functional aspects of the interaction between attentional/control processes and learning/memory processes. The network of brain regions supporting recall of abstract designs were studied in a less practiced and in a well practiced state. The results indicate that automaticity, i.e., a decreased dependence on attentional and working memory resources, develop

Familial thrombophilia : Resistance to activated protein C and protein S deficiency

Inherited resistance to activated protein C (APC-resistance) and protein S deficiency are associated with functional impairment of the protein C anticoagulant system, resulting in lifelong hypercoagulability andincreased risk of thrombosis. APC-resistance is the most common genetic cause of thrombosis being present in 20% to 60% of thrombosis patients.A linkage study was performed in a large throm

A standardized and reproducible protocol for serum-free monolayer culturing of primary paediatric brain tumours to be utilized for therapeutic assays.

In vitro cultured brain tumour cells are indispensable tools for drug screening and therapeutic development. Serum-free culture conditions tentatively preserve the features of the original tumour, but commonly comprise neurosphere propagation, which is a technically challenging procedure. Here, we define a simple, non-expensive and reproducible serum-free cell culture protocol for establishment an

Conformational dynamics and thermodynamics of protein-ligand binding studied by NMR relaxation.

Protein conformational dynamics can be critical for ligand binding in two ways that relate to kinetics and thermodynamics respectively. First, conformational transitions between different substates can control access to the binding site (kinetics). Secondly, differences between free and ligand-bound states in their conformational fluctuations contribute to the entropy of ligand binding (thermodyna

Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.

In adipocytes, lipolysis is a highly regulated process involving hormonal signals, lipid droplet-associated proteins, and lipases. The discovery of new lipid droplet-associated proteins added complexity to the current model of lipolysis. In this study, we used cultured human adipocytes to demonstrate that fat-specific protein 27 (FSP27), an abundantly expressed protein in adipocytes, regulates bot

Diagnostic of laser contrast using target reflectivity

Using three different laser systems, we demonstrate a convenient and simple plasma based diagnostic of the contrast of high-power short-pulse lasers. The technique is based on measuring the specular reflectivity from a solid target. The reflectivity remains high even at relativistic intensities above 10(19) W/cm(2) in the case of a high-contrast prepulse-free laser. On the contrary, the specular r

Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3.

The conformational entropy of proteins can make significant contributions to the free energy of ligand binding. NMR spin relaxation enables site-specific investigation of conformational entropy, via order parameters that parameterize local reorientational fluctuations of rank-2 tensors. Here we have probed the conformational entropy of lactose binding to the carbohydrate recognition domain of gale

Benefits and constrains of covalency : the role of loop length in protein stability and ligand binding

Protein folding is governed by non-covalent interactions under the benefits and constraints of the covalent linkage of the backbone chain. In the current work we investigate the influence of loop length variation on the free energies of folding and ligand binding in a small globular single-domain protein containing two EF-hand subdomains—calbindin D9k. We introduce a linker extension between the s

Strategisk plan 2017-2026 eng

PowerPoint-presentation Strategic Plan Lund universitY 2017–2026 A world-class university that works to understand, explain and improve our world and the human condition The vision. In the slide show view, the Youtube icon links to a short film about the strategic plan. Priority areas 2017–2026 Education and research are to be intertwined Stimulating active collaboration to solve societal challeng

https://www.staff.lu.se/sites/staff.lu.se/files/strategisk_plan_2017-2026_eng.pptx - 2026-05-03

Optimal processtemperatur vid mesofil samrötningsprocess

Syftet med detta examensarbete har varit att undersöka hur en förändring av processtemperatur kan påverka processtabilitet och produktion av biogas hos OX2. Anläggningen som drivs och förvaltas av OX2 Bio produktion AB i Helsingborg producerar biogas från främst matavfall från hushåll och från livsmedelsindustrin. Idealt produceras bio-gas i anläggningen vid 37 °C men under året finns en variationThe purpose of this master thesis has been to investigate how a change in process temperature can affect the stability and production of biogas. The plant which is operated and administrated by OX2 Bio Produktion AB located in Helsingborg produces biogas from primarily household food waste and waste from food industry. An ideal temperature to produce biogas at the plant is 37 °C but there is a flu

Copyright and Freedom of Expression in Sweden and the European Union - The Conflict Between Two Fundamental Rights in the Information Society

Upphovsrätt och rätten till yttrandefrihet faller båda in under kategorin fundamentala rättigheter inom den Europeiska unionen (EU) och de förtjänar att åtnjuta skydd därefter. Men vad är det närmare rättsliga och faktiska förhållandet mellan dessa båda rättigheter i dagens informationssamhälle? Detta är en av tre frågor som skärskådas i uppsatsen. Presentationen ger vid handen att den traditionelCopyright and the right to freedom of expression both constitute fundamental rights in the European Union (EU) and should be protected accordingly. But what is the closer relationship, de jure and de facto, between these two legal regimes in the information society? This is one of three questions examined in this thesis. The presentation gives at hand that, traditionally, the notion has been that

Copyright

In order for your publications to be made freely accessible in LUCRIS you need to own the copyright to them. Presented below are a few copyright-related starting points based on a rough classification of different types of publications. The purpose of copyright law is to balance the author’s protection needs against the user’s access needs. Therefore, the law is combined with reasonable exceptions

https://www.lub.lu.se/en/services-and-support/publishing-and-registering/open-access/self-archiving/copyright - 2026-05-01

Effect of aluminum on microstructure and properties of martensitic wear-resistant and heat-resistant steel

The effect of aluminum on microstructure and properties of martensitic wear-resistant and heat-resistant steels was investigated. The results indicate that as-cast microstructure of the specimens is composed of ferrite, pearlite and carbides. After quenching at 1,000 C and tempering at 600 C, the microstructure of the specimens consists of tempered sorbite and Fe-Cr-Al intermetallic compounds whic

Improved Urinary Cortisol Metabolome in Addison Disease : A Prospective Trial of Dual-Release Hydrocortisone

CONTEXT: Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy has demonstrated an improved metabolic profile compared to conventional 3-times-daily (TID-HC) therapy among patients with primary adrenal insufficiency. This effect might be related to a more physiological cortisol profile, but also to a modified pattern of cortisol metabolism. OBJECTIVE: This work aimed to study cor

A2030 monthly Update 240110

Agenda 2030 Graduate School monthly newsletter #1 2024-01-10 Ylva van Meeningen Hi! Hope you all have had a great holiday and are feeling refreshed. Maybe you are even still on holiday or doing fieldwork? We at the Agenda 2030 Graduate School office are now back in action and Markus Gunneflo has stepped into the ring as our new coordinator. It is with much excitement we are looking forward to a ne

https://www.agenda2030graduateschool.lu.se/sites/agenda2030graduateschool.lu.se/files/2024-06/A2030_monthly%20update_240110.pdf - 2026-05-03

The sarcopenia index measured using the lumbar paraspinal muscle is associated with prognosis in endometrial cancer

Objective: The number of type-II endometrial cancer patients has been increasing and the prognosis is not favorable. We aim to investigate whether sarcopenia index in any of several different muscles could serve as a novel biomarker of prognosis in patients with type-II endometrial cancer. Methods: We retrospectively investigated a total of 194 patients at four hospitals. Ninety patients were trea

Var är min hemvist? - En jämförelse mellan hemvistbedömningen i EU:s arvsförordning och svensk skatterätt

Det blir allt vanligare att människor flyttar mellan länder för att bo, studera, arbeta eller leva som pensionär. Till en persons hemvist knyts allt fler rättigheter och skyldigheter i samhället vilket skapar ett ökat behov för individen och staten att kunna fastställa var en person har sin hemvist. Idag finns ingen enhetlig tolkning av hemvistbegreppet. En persons hemvist kan därför variera mellaToday it is common for people to move across borders to live, study, work or retire. A person’s residence is linked to an increasing number of rights and obligations in society, which creates an increased need for both the individual and the state to determine where a person has its residence in different situations. Today there is no uniform interpretation of the concept. Where a person is consid