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GRACILE syndrome (Fellman syndrome, MIM 603358), an autosomal recessive metabolic disorder of the Finnish disease heritage, has been diagnosed in 25 infants of 18 families. The incidence is at least 1/47,000 in Finland. The main findings are fetal growth retardation, Fanconi type aminoaciduria, cholestasis, iron overload (liver hemosiderosis, hyperferritinemia, hypotransferrinemia, increased trans
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
Background: Hypofractionated radiotherapy for prostate cancer has gained increased attention due to its proposed high radiation-fraction sensitivity. Recent reports from studies comparing moderately hypofractionated and conventionally fractionated radiotherapy support the clinical use of moderate hypofractionation. To date, there are no published randomised studies on ultra-hypofractionated radiot
The metaphor of a potential epigenetic differentiation landscape broadly suggests that during differentiation a stem cell approaches a stable equilibrium state from a higher free energy towards a stable equilibrium state which represents the final cell type. It has been conjectured that there is an analogy to the concept of entropy in statistical mechanics. In this context, in the undifferentiated
Increasing demand for detecting single molecules in challenging environments has raised the bar for the fluorophores used. To achieve better resolution and/or contrast in fluorescence microscopy, it is now essential to use bright and stable dyes with tailored photophysical properties. While long fluorescence lifetime fluorophores offer many advantages in time-resolved imaging, their inherently low
Non-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related morbidity and mortality worldwide. In the current work, we used an exploratory data analysis to investigate time-dependent cellular and mitochondrial effects of different supra-physiological fatty acids (FA) overload strategies, in the presence or a
Summary: In elderly men included in MrOS-Sweden, subclinical hyperthyroidism (SHyper) was markedly associated with increased risk of vertebral fractures. Introduction: Overt hyperthyroidism is associated with increased risk of fractures. However, only a few studies have investigated whether SHyper is associated with fracture risk in elderly men. We therefore investigated if SHyper was a risk facto
Background Intracellular delivery of antimicrobial agents by nanoparticles, such as mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular infections. In tuberculosis (TB), Mycobacterium tuberculosis avoids components of the immune system by residing primarily inside alveolar macrophages, which are the desired target for TB therapy. Methods and findings We have p
OBJECTIVE: To use microarray analyses of gene expression to characterize the synovial molecular pathways regulated by the arthritis regulatory locus Cia25 and to determine how it operates to control disease severity and joint damage.METHODS: Synovial tissues from DA rats and DA.ACI(Cia25) rats obtained 21 days after induction of pristane-induced arthritis were used for RNA extraction and hybridiza
Immobilised 1,3-specific lipase from Rhizopus arrhizus was used as catalyst for the esterification of dl-glycero-3-phosphate and fatty acid or fatty acid vinyl ester in a solvent-free system. With lauric acid vinyl ester as acyl donor, a(w)<0.53 favored the synthesis of lysophosphatidic acid (1-acyl-rac-glycero-3-phosphate, LPA1) and the spontaneous acyl migration of the fatty acid on the molecule
BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer.METHODS: In this double-blind, placebo-contro
DMSO är ett vanligt lösningsmedel för studier av syntetiska molekyler i biologiska system, bl.a. inom läkemedelsutveckling. Trots detta är lösningsmedlets interaktioner med dessa syntetiska molekyler och deras målprotein inte tillräckligt undersökta. DMSO kan påverka proteinerna struktur eller ha någon annan inverkan inbindningen. I detta arbete har denna möjliga effekt studerats för inbindningen DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. DMSO could potentially have significant effect on binding characteristics due to conformational changes of protein structur
I ett allt mer individbaserat samhälle, med ett skifte från normer när det gäller levnadssätt till allas unika livsval, ser vi ett ökat behov av boende för olika typer av konstellationer. Kärnfamiljen är inte lika självklar längre, ensamhushållen är fler och separationer är vanligt. Människor kan välja att bli förälder på egen hand och tvåsamhet som en självklarhet ifrågasätts helt och hållet. Vi In our individualized society, with a shift from strict norms on how we live our lives to everyone’s own unique lifestyle, we see a growing need for diversified housing for different types of constellations. The nuclear family is not a certainty anymore, the number of single residencies have increased and separations are common. People can choose to become a parent on their own and twosome relatio
I folkrättsligt hänseende är en stat endast skyldig att låta de egna medborgarna uppehålla sig på dess territorium. Ur ett EU-rättsligt perspektiv är dock varje medlemsstat förpliktad att tillämpa de regler som avser främja fri rörlighet för personer inom unionen. Dessa återfinns i EU:s primärrättsliga stadganden men konkretiseras genom sekundärrättsliga bestämmelser, framförallt genom direktiv 20With regard to international law, a state is only required to allow its citizens to reside within its own territory. However, from an EU law perspective, each Member State is obliged to apply regulations which intend to facilitate the free movement of persons within the EU. This is expressly laid down in the EU treaties, but must be viewed within the context of secondary law, in particular, the Ci
After the 1980s, neoliberalism became the dominant philosophy of development across the world. Whereas the widespread implementation of neoliberal economic policies contributed immensely for a maximization of world economic integration and activity, critics argue that the ideology was also responsible for dramatically widening the inequality gap between and within nations, as well as for the incre
Department o f Psychology Management Group o f the Two-Year Master o f Sc ience Programme in Psychology Minutes of the Management Group Present Chair Secretary of the Minutes Members of the management group Right to attend and speak Absent Roger Johansson programme director Åsa Arvidsson (substitute for Lucie Nilsson) Anika Draeger student representative Johannes Gramstad student representative Pe
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/2026-04/Master%20minutes%202026-03-26.pdf - 2026-05-07
OBJECTIVES: Tumour necrosis factor-α inhibitor (TNFi) treatment has been shown to reduce the rates of anterior uveitis (AU) in patients with ankylosing spondylitis (AS). Our objective was to compare the effect of adalimumab (ADA), etanercept (ETN) and infliximab (IFX) on AU occurrence in AS, using real-world data.METHODS: Patients with AS starting ADA, ETN or IFX as their first TNFi from January 2
ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente
