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The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. The antiproliferative effect toward HFL-1 cells was correlated with the polarity of the compounds. However, in the case of transformed T24 cells, some compounds showed a clearly different behavior resul

The adhesion of water to solid surfaces is characterized by the tendency to balance competing molecule-molecule and molecule-surface interactions. Hydroxyl groups form strong hydrogen bonds to water molecules and are known to substantially influence the wetting behaviour of oxide surfaces, but it is not well-understood how these hydroxyl groups and their distribution on a surface affect the molecu

Poly(ethylene-co-vinyl acetate)/organically modified clay nanocomposites were prepared using different clay loadings and by varying the amount of organic modifier. The morphology of the nanocomposites was investigated using small-angle X-ray scattering (SAXS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). SAXS results displayed intercalation of polymeric chains be

The sequestration of calcium phosphate by unfolded proteins is fundamental to the stabilization of biofluids supersaturated with respect to hydroxyapatite, such as milk, blood or urine. The unfolded state of osteopontin (OPN) is thought to be a prerequisite for this activity, which leads to the formation of core-shell calcium phosphate nanoclusters. We report on the structures and dynamics of a na

Flat-histogram techniques provide a powerful approach to the simulation of first-order-like phase transitions and are potentially very useful for protein studies. Here, we test this approach by implicit solvent all-atom Monte Carlo (MC) simulations of peptide aggregation, for a 7-residue fragment (GIIFNEQ) of the Cu/Zn superoxide dismutase 1 protein (SOD1). In simulations with 8 chains, we observe

Black holes exceeding a billion solar masses have been detected at redshifts greater than six. The rapid formation of these objects may suggest a massive early seed or a period of growth faster than Eddington. Here we suggest a new mechanism along these lines. We propose that in the process of hierarchical structure assembly, dense star clusters can be contracted on dynamical timescales due to the

Regulatory frameworks within the European Union demand that chemical substances are investigated for their ability to induce sensitization, an adverse health effect caused by the human immune system in response to chemical exposure. A recent ban on the use of animal tests within the cosmetics industry has led to an urgent need for alternative animal-free test methods that can be used for assessmen

Polymeric catalysts to be applied in the Diels-Alder cycloaddition of hexachlorocyclopentadiene and maleic acid have been prepared via molecular imprinting with template molecules immobilized on silica particles. These enzyme mimicking polymers exhibit specific catalytic effects compared to non-imprinted control polymers or polymer-free solutions. It could be demonstrated that the activity of the

Page 1 of 3 Department of Biology Education- Bachelor's and Master's level COURSE ANALYSIS Date 2024-11-13 Main Teacher: Tobias Uller Number of students: 10 Number of answers: 5 Grades: Course Analysis: Evolutionary Biology: Patterns and Processes, BIOR89, autumn 2024 Summary of the course evaluation Unfortunately, only 50% (5 out of 10) students completed the evaluation. This is a lower response

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/36af581b0da03d44cfecf22c1f44f573dcb92b17_BIOR89_2024_kursanalys.pdf - 2026-05-08

Gröna tak kan minska problem med s.k. urban heat islands och kan användas för dagvattenhantering. Andra miljöfördelar som en förbättring av luftkvalitet, biodiversitet och bullerminskning finns också. Detta projekt fokuserar på lokala (kommunala) medel för att skapa en bättre miljö med extensiva gröna tak, vilka är nästan underhållsfria. Ett delområde i Lund som inkluderar Universitetet och UniverGreen roofs have the potential to mitigate problems with an urban heat island and to act as an element in stormwater management. Other environmental benefits exist as well, such as improvement of air quality, biological diversity and noise reduction. This project focuses on local community efforts to create a better environment through the use of extensive green roofs, which require almost no main

Sammanfattning Studien behandlar polisens roll i straffprocessen genom att beskriva hur polisens faktiska inflytande i den dömande verksamheten har ökat i samband med målet på en effektivare lagföring. Utredningen visar att allt fler brottsanmälningar lämnas utan åtgärd i ett led att frigöra resurser, medan andra brott beivras utanför domstol genom strafförelägganden och ordningsböter. Utredning

Popular Abstract in Swedish Mesenteriell ischemi (nedsatt blodcirkulation till tarm och övriga bukorgan) är vanligt förekommande vid ett flertal olika sjukdomstillstånd som t ex blödnings-, septisk och cirkulatorisk chock. Inte minst är tarmen mycket känslig för nedsättning av blodflödet. Tarmskadan, inkluderande dess barriär(skydds-)funktion sker dels under perioden med nedsatt blodförsörjning meIntestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction

Hypothesis: Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation in suitable carriers. However, DX has a high solubility in water, hindering encapsulation. The formulation of DX with sodium cholate (NaC) will reduce aqueous solubility thro

Background: Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but based on previous randomized controlled trials and observational studies, there are still uncertainties about the safety in giving low-grade RBC transfusions to patients with sep

Background We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. Methods EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diag