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Increased hope following successful treatment for hepatitis C infection

Aims: To evaluate hope in hepatitis C patients 9 years after curative treatment with pegylated interferon and ribavirin. Background: Successful treatment of hepatitis C leads to improved quality of life in responders compared with non-responders. The long-term effect of successful treatment on hope in these patients is not known. Design: Cross-sectional follow-up study of patients who displayed a

Pain, Quality of Life, and Safety Outcomes of Kyphoplasty for Vertebral Compression Fractures : Report of a Task Force of the American Society for Bone and Mineral Research

The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. We searched multiple electronic databases to March 2016 for randomized and quasi-randomized controlled trials comparing BK with control treatment (nonsurgical management [NSM], percutaneous vertebroplasty [PV], KIVA VCF treatment system [Benvenue Medical, Inc., Santa Clara,

Pain and health status in adults with myelomeningocele living in Sweden

PURPOSE: To increase knowledge about pain and general health in adults with myelomeningocele, a health condition with several risk factors for pain such as musculoskeletal deformities, shunt dysfunctions, bowel problems, and urinary tract infections/stones. METHODS: Descriptive correlational pilot study (N= 51, 53% males). Chi-square tests were used to test associations among presence, impact, sev

Factors associated with health-related quality of life among adults with tetralogy of Fallot

Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D index was ca

Agreement Between Breathlessness Severity and Unpleasantness in People With Chronic Breathlessness : A Longitudinal Clinical Study

Context: Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective: We aimed to evaluate agreement between breathlessness severity and unpleasantness over eight days in patients with chronic breathlessness. Methods: Longitudinal analysis of 265 patients with chronic breathlessness w

A longitudinal 2-year follow-up of quality of life in women referred for colposcopy after an abnormal cervical smear.

OBJECTIVE: To evaluate the long-term impact on quality of life (QoL) in women referred for colposcopy after an abnormal cervical smear. STUDY DESIGN: One hundred consecutive women referred for colposcopy for the first time subsequent to receiving notification of an abnormal cervical smear. Women in the study group completed the Swedish Health Survey Short Form-36 (SF-36), the State/Trait Anxiety I

Fatigue During Cancer-Related Radiotherapy and Associations with Activities, Work Ability and Quality of Life : Paying Attention to Subgroups more Likely to Experience Fatigue

Background: Having knowledge of which patients are more likely to experience fatigue during radiotherapy and the relationship between fatigue and health-related quality of life (HRQL) is important to improve identification and care of patients experiencing burdensome fatigue. Objective: To identify subgroups of patients, varying in situational, physiological, and psychological factors, who are mor

Identifying essential COVID-19 indicators for primary healthcare through Delphi analysis in 31 European countries: Eurodata eDelphi study

Background The COVID-19 pandemic has underlined the essential role of primary healthcare (PHC) in epidemiological surveillance and public health decision-making. Across Europe, the integration of electronic health records (EHRs) and the sentinel networks have been pivotal in monitoring COVID-19. However, the lack of standardized PHC indicators for COVID-19 hinders the comparability of data among c

Lung Function and Health Status in Individuals with Severe Alpha-1-Antitrypsin Deficiency at the Age of 42

Background: Severe hereditary alpha-1-antitrypsin deficiency (AATD) is a known risk factor for the early development of pulmonary emphysema and COPD, especially in smo-kers. By the Swedish national screening programme carried out from 1972 to 1974, a cohort of individuals with severe (PiZZ) AATD was identified and has been followed up regularly. The aim of this study was to investigate health stat

Students’ and Teachers’ Experience of Globalization/Internationalization ‘of’ Higher Education - Emphasizing a pedagogical stance in an internationalized teaching and learning context

The conclusions in this paper are drawn from the results of four empirical studies. It has been important to take an empirical approach in the investigation, concerned with internationalization of higher education, since even though plentiful of studies over the last decades have been concerned with internationalization in/of higher education, it has not been from the perspectives from the teacher

Life satisfaction in patients with and without spinal cord Ischaemia after advanced endovascular therapy for extensive aortic disease at mid-Term follow-up

Objective: Advanced endovascular aortic repair can be used to treat patients with extensive and complex aortic disease who are at risk of spinal cord ischaemia. The aim of this study was to compare whether life satisfaction differs between patients with and without spinal cord ischaemia at mid-Term follow-up. Design: Nested case-control study. Patients: Among patients undergoing advanced endovascu

Hip disorders and osteoarthritis: focus on health-related quality of life, assesssment and intervention

Popular Abstract in Swedish De övergripand syftena med dessa studier var att undersöka vilka konsekvenser höftbesvär och höftledsartros har på hälsorelaterad livskvalité, fysisk förmåga och tilltro till egen förmåga. Höftledsartros är ofta förknippad med svår smärta och påverkar både fysiska funktioner och livskvalité. Förekomsten av höftbesvär, i en befolkningsgrupp i södra Sverige, var 32%, och The overall aims of this work were to investigate the consequences of hip disorders and hip osteoarthritis (OA) on health-related quality of life (HRQL) physical function and self-efficacy. The condition, hip OA, is often associated with significant pain and has a strong impact on physical function and quality of life. The prevalence of hip disorders were 32% and among the individuals reporting h

Quality of Life and Supportive Care after Oesophageal Cancer Surgery. Long-term experiences and evaluation of a telephone based nurse-led supportive care programme

After oesophageal cancer surgery it is known that patients have a reduced QOL and that they suffer an unmet need of support. The overall aim of this thesis was to investigate patients’ experiences of QOL and supportive care as well as to evaluate a telephone based nurse-led supportive care programme to patients after oesophageal cancer surgery. The thesis comprises two quantitative (I, IV) and tw

The Moral Rubicon. A Study of the Principles of Sanctity of Life and Quality of Life in Bioethics.

Popular Abstract in Swedish Avhandlingen behandlar frågan om vad man i Sverige brukar kalla "människovärde". Denna fråga belyses genom en analys av begreppen "livets helgd" och "livskvalitet" som i den anglo-saxiska debatten har kommit att symbolisera två helt olika sätt att tolka det mänskliga livet värde. Tanken om livets helgd brukar anföras av dem som tror att livets värde är inneboende och iThe principles of sanctity of life and quality of life are often appealed to in medical decisions at the "edges of life." Notwithstanding their importance in bioethics, these principles are still badly understood. This study is an attempt to clarify their normative significance and content. Because these principles pertain to the more general question of the value of life, the study begins by exp

Living with cancer in old age. Quality of life and meaning.

Popular Abstract in Swedish ”Att leva med cancer som äldre, livskvalitet och upplevelse av mening” Cancer drabbar företrädesvis äldre personer och är en sjukdom som blir vanligare i takt med det stigande antalet äldre i befolkningen. Cancer hos äldre innebär en komplex situation eftersom åldrandet är präglat av stora individuella förändringar med ökande sjuklighet, nedsatt funktionell förmåga, föThe overall aim of this thesis was to investigate quality of life in people aged 75 and older with cancer in relation to age, gender, presence and type of complaints, comorbidity, living conditions, perceived economic situation, sense of coherence, receiving help for daily living and social resources. The aim was also to investigate older people’s experiences and the meaning of living with cancer

Datorstöd i skrivandet: En longitudinell studie på grundskolan och gymnasieskolan

This dissertation studies the effects that the use of a word-processing program can have on pupils' writing. The study was conducted with a consideration of the context in which the writing was done. It examined not just changes in the quality of the pupils' writing but also the attitudes of pupils, teachers, and parents to computer-aided writing. In addition, it studied the functional reliability

Aspects of autoantibody epitopes in type 1 diabetes

Popular Abstract in Swedish I Sverige insjuknar två barn i autoimmun diabetes (typ 1 diabetes) varje dag. Typ 1 diabetes (T1D) är en kronisk autoimmun sjukdom som kan få livshotande konsekvenser vid utebliven behandling. Sverige har den högsta incidensen av T1D i hela världen efter Finland. Förutom att den delvis är ärftlig vet man inte vilken eller vilka faktorer som triggar sjukdomen. Sedan mittType 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. The single nucleotide polymorphism (SNP) rs13266634 in th