Sökresultat

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

Sustainable energy storage and conversion utforskar innovativa metoder för att effektivt lagra och omvandla energi från olika förnybara källor. Fokus ligger på teknik som avancerade batterier, vätgasproduktion, bränsleceller och termokemiska system samt säkerhetsaspekter på batterilagringssystem. Forskningen syftar till att öka energitätheten, minska kostnaderna och förbättra skalbarheten, vilket

https://www.energy.lth.se/sv/forskning/lagring-och-omvandling-av-energi - 2026-04-21

14 mars 2025 18:00 | Teater, Övrigt 25 min performative installation Please arrive on time. The doors will be closed at 18:00. The situation is pneumological. A moment of mine, of our bodies. Intimate, humid, unanimous. Unknowable. We share an invisible volume. It reveals itself through the colours of light. This is where my eyes come to be. They should first gaze upon my movements. But they first

https://www.lu.se/evenemang/juju-bento-dreaming-about-blue-sky-above - 2026-04-22

6 mars 2026 17:00 till 21 mars 2026 16:00 | Utställning What does it mean to exist in the hesitating gap between knowing and not knowing. This show might be such a gap; intimate, political, fictitious and real, collapsed and wide. An art show is just another situation of being in the process of perceiving, feeling, and making sense.I find it hard to distinguish between realities and fictions. The

https://www.lu.se/evenemang/if-you-know-where-treasure-you-can-rob-it-line-rolf - 2026-04-22

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

16 april 2026 15:00 till 16:00 | Övrigt Join us for this special episode of the Lund University International Podcast, live from Stadshallen: discover how international students from around the world weave sustainability into their life and studies at Lund, often in ways they never expected, as we discuss how your surroundings can inspire more sustainable habits. International students at Lund Uni

https://www.lu.se/evenemang/live-podcast-living-sustainably-international-student - 2026-04-22

15 maj 2025 09:00 till 16 maj 2025 17:00 | Konferens The Italian Research Day in the World (GRIM) is an initiative by the Italian Ministry of University and Research, and the Ministry of Foreign Affairs. Organised by the Italian Embassies all over the world, it aims at highlighting the contributions of Italian researchers working abroad and at showcasing Italy's commitment to science, technology,

https://www.lu.se/evenemang/italian-research-day-world-2025-lund - 2026-04-22

21 oktober 2025 12:00 till 22 oktober 2025 15:15 | Workshop Integrative Structural Biology (ISB) is a rapidly advancing field that relies on the integration of diverse datasets, such as those from Cryo-electron microscopy, X-ray crystallography, NMR, Mass spectrometry and Modeling. By integrating different structural techniques we can solve the structure of challenging biological systems, which wo

https://www.lu.se/evenemang/workshop-enhancing-cross-platform-collaboration-integrative-structural-biology - 2026-04-22

16 maj 2025 15:00 till 23 maj 2025 16:00 | Utställning Bertrand Chavarría-Aldrete, PhD student at the Malmö School of Music, who will defend his dissertation "Plastic Extension of Music" on 22 May 2025, invites you to an extended exhibition that visualises his "Plastic Extensions of Music" in various genres. Opening hours:16 May 2025, at 15:00 – Vernissage19–21 May 2025, at 13:00–16:0022 May 2025,

https://www.lu.se/evenemang/phd-defense-exhibition-bertrand-chavarria-aldrete - 2026-04-22

https://www.lu.se/evenemang/sall-lam-toro-water-stirs-our-grief-choir-tears - 2026-04-22

https://www.lu.se/evenemang/premiar-subkulturen - 2026-04-22

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m