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The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolut

Dubois, Rucker, and Galinsky (2012, Experiment 1) found that consumers view larger-size options as a signal of higher status. We conducted a close replication of this finding (N = 415), and observed a nonsignificant effect in the opposite direction (small vs. large product size: doriginal = 1.49, 95%CI [1.09, 1.89], dreplication = 0.09 95%CI [-0.15, 0.33]; medium vs. large: doriginal = 0.89 95%CI

Aim: To compare total metabolic tumour volume (tMTV), calculated using two artificial intelligence (AI)-based tools, with manual segmentation by specialists as the reference. Methods: Forty-eight consecutive Hodgkin lymphoma (HL) patients staged with [18F] fluorodeoxyglucose positron emission tomography/computed tomography were included. The median age was 35 years (range: 7–75), 46% female. The t

Background: Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid retention. The use of TZDs has been further hampered by the risk of adverse cardiovascular events including heart failure. The present study evaluated the effect of pioglitazone or ins

The ALICE Collaboration has made the first measurement at the LHC of J/psi photoproduction in ultra-peripheral Pb-Pb collisions at root s(NN) = 2.76 TeV. The J/psi is identified via its dimuon decay in the forward rapidity region with the muon spectrometer for events where the hadronic activity is required to be minimal. The analysis is based on an event sample corresponding to an integrated lumin

Since the discovery of a formal quintuple bond in Ar'CrCrAr' (CrCr = 1.835 angstrom) by Power and co-workers in 2005, many efforts have been dedicated to isolating dichromium species featuring quintuple-bond character. In the present study we investigate the electronic configuration of several, recently synthesized dichromium species with ligands using nitrogen to coordinate the metal centers. The

BACKGROUND: The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation. OBJECTIVE: The aim was to examine whether dietary factors (macronutrient and fiber intakes) and leisure-time physical activity modify the association between genetic variation in FTO and body mass index (BMI; in kg/m(2)). DESIGN: A cross-sectional study exam

This thesis examines in what way Brexit is constructed as a security threat with regards to the Irish border. If the UK were to leave the EU a border would have to be installed, but installing a border between Northern Ireland and the Republic of Ireland would violate the Good Friday Agreement. Brexit has resulted in a prolonged process because the politicians cannot agree on a withdrawal agreemen

Popular Abstract in English The human plasma proteome containing disease-correlated protein biomarkers reflects the pathological and physiological changes relating to diseases. These biomarkers are of interest to aid in diagnosis, prognosis and monitoring of diseases such as cancer. Because of the interests in the disease-correlated biomarkers, plasma, although is a complex biological sample, spanThe blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. The focus in this thesis is the development and application of several integrated platforms to detect already established protei

Background: P-selectin is activated early after stroke, followed by a rapid decline. This time course can be used to generate important information on stroke onset. The latter is crucial for therapeutic decision-making of wake-up strokes (i.e. thrombolysis or not). Here, we evaluated the specific p-selectin inhibitor fucoidan labeled with gallium-68 (68Ga-Fucoidan) as an imaging biomarker for asse

Background: Swefoot is a Swedish national registry, that covers surgery in the foot and ankle. Surgical treatment of hallux rigidus (HR) vary within and between countries. The aim of this study was to report baseline variables for patients with HR. Methods: We extracted baseline characteristics, surgical procedures and patient-reported data for patients with HR entered in the registry during the p

PURPOSE: To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers.METHODS: Between May 2016 and March 2017, 8 volunteers (25 ± 4 years, 3 female) and 8 pigs (4 female) underwent ECV assessment with SASHA, MOLLI5(3b)

Currently, local regulations governing hydrogen installations vary by geographical region and by country, leading to discrepancies in safety and separation distance requirements for similar hydrogen systems. This work carried out in the frame of IEA TCP H2 Task 43 (IEA TCP H2 2022) aims to provide an overview of various methodologies and recommendations established for risk management and conseque

lum_2008_07 LUM Lunds universitets magasin | Nr 7 | 2008 högt i tak Vad har Utrecht som Lund saknar? Professur i blåsväder 2 LUM nr 7 | 2008 orört krypin LUM nr 7 | 2008 3 Årtusendens vind och regn gröp- te ur klippan. Någon gång un- der historiens lopp rasade en bit från berget och föll som en jätte- snäcka, med håligheten neråt. I grottan som bildades sökte männis- kor skydd. Det hände i Sydafri

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-7-2008.pdf - 2026-05-27