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Tillämpningen av förklaringsbördan i brottmålsförfarandet och dess förhållande till den tilltalades rätt att vara passiv enligt Europakonventionen

Var och en som har blivit anklagad för ett brott åtnjuter en rätt till tystnad och att betraktas som oskyldig genom det straffprocessuella förfarandet fram till en eventuellt fällande dom. Dessa grundläggande rättigheter tillförsäkras den tilltalade genom artikel 6.1 och 6.2 EKMR. Som en följd av dessa rättigheter ligger bevisbördan i brottmål uteslutande på åklagaren, vilket medför en rätt för deEveryone charged with criminal offense has the right to remain silent and to be presumed innocent until proven guilty in criminal proceedings. The accused is assured these fundamental rights according to article 6.1 and 6.2 ECHR. Due to these rights, the burden of proof must lie on the prosecutor, which means that the accused has the right to remain completely passive during criminal proceedings.

Ozonation-Induced Changes of Azathioprine and Flutamide : A Non-Targeted Analysis Using UHPLC-IM-HRMS and NMR

Cytostatika är läkemedel som används för att behandla cancer genom att hämma eller stoppa celldelning. De används även som immunhämmande medel, till exempel vid organtransplantationer och autoimmuna sjukdomar. Eftersom dessa läkemedel påverkar cellers tillväxt kan de vara skadliga även i mycket små mängder om de hamnar i miljön. Cytostatika har upptäckts i ytvatten, grundvatten och dricksvatten i Introduction: Cytostatic pharmaceuticals are increasingly detected in the aquatic environment, raising concerns due to their persistence and toxicity. Background: Conventional wastewater treatment processes do not effectively remove these compounds. Advanced oxidation processes, such as ozonation, are needed to degrade cytostatic pharmaceuticals during wastewater treatment. However, these process

Multi-layered censorship in times of Rally Around the Flag: The case of the Second Nagorno-Karabakh war

During the Second Nagorno-Karabakh War, media coverage was heavily restricted and aligned with official narratives. Throughout the 44 days of fighting, the Armenian public was exposed almost exclusively to patriotic content—even from independent outlets—circulated under the constant presence of the official slogan, “We will win.” As a result, when the war ended in a significant defeat for the Arme

Assessing mammographic density change within individuals across screening rounds using deep learning–based software

Purpose: The purposes are to evaluate the change in mammographic density within individuals across screening rounds using automatic density software, to evaluate whether a change in breast density is associated with a future breast cancer diagnosis, and to provide insight into breast density evolution. Approach: Mammographic breast density was analyzed in women screened in Malmö, Sweden, between 2

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2

Rest, shade, hydration and hygiene for the prevention of kidney injuries and inflammation in a Nicaraguan sugarcane worker cohort

Objectives To study the effect of a progressively enhanced rest–shade–hydration–hygiene (RSHH) intervention on kidney injury and inflammation biomarkers, and rates of clinical acute kidney injury (AKI) in Nicaraguan sugarcane workers with a very high rate of chronic kidney disease of non-traditional origin (CKDnt). Methods We analysed serum creatinine and C-reactive protein (CRP) and leukocyturia

Short and long-term prognosis of hospitalization for dyspnoea based on aetiology and hospitalization ward: insights from the PARADISE cohort

AimsDyspnoea accounts for nearly 5% of emergency department (ED) visits. Our aim was to describe the in-hospital and long-term outcomes of patients admitted to the ED for dyspnoea, based on their underlying aetiology, and to determine if prognosis varies according to the hospitalization setting.MethodsWe analyzed 18 903 consecutive patients (48% male, average age 73 years) hospitalized after an ED

Randomized Trial of Very Early Medication Abortion

Background Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations before a pregnancy can be visualized with ultrasonography. Methods We conducted a multicenter, noninferiority, randomized, controlled trial involving women requesting medication abortion at up to 42

Age and sex differences in vasovagal syncope : triggers, clinical presentation, prodromal symptoms, and head-up tilt test results

AIMS: Previous studies show inconsistencies in vasovagal syncope (VVS) symptoms and haemodynamic responses across age and sex groups, with limited evaluation of tilt test results. This study comprehensively examines differences in triggers, prodromal and syncopal symptoms, and head-up tilt test (HUTT) responses among VVS patients by age and sex providing new insights.METHODS AND RESULTS: We analys

Hip dysplasia as risk factor for clinically relevant and radiographic hip osteoarthritis : 10-year results from the CHECK cohort

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade

Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins

A new member of the human cystatin superfamily, called cystatin E, has been found by expressed sequence tag (EST) sequencing in amniotic cell and fetal skin epithelial cell cDNA libraries. The sequence of a full-length amniotic cell cDNA clone contained an open reading frame encoding a putative 28-residue signal peptide and a mature protein of 121 amino acids, including four cysteine residues and

Features associated with epilepsy in the antiphospholipid syndrome

OBJECTIVE: To assess the frequency of epilepsy in primary and secondary antiphospholipid syndrome (APS); to analyze the clinical and laboratory features characterizing those with epilepsy in a cohort of 538 patients with APS; and to find associated features that would suggest risk factors for epilepsy in APS. METHODS: We analyzed the clinical features of patients with APS who had epilepsy and comp

How do fluctuating temperatures alter the cost of development?

Quantifying how variable temperature regimes affect energy expenditure during development is crucial for understanding how future thermal regimes may impact early life survival and population persistence. Developmental cost theory (DCT) suggests that there is an optimal temperature (Topt) that minimises energy expenditure during development (the ‘cost of development‘). Exposure to fluctuating temp

Prompt Thrombo-Inflammatory Response to Ischemia-Reperfusion Injury and Kidney Transplant Outcomes

Introduction: In kidney transplantation (KT), the role of the intravascular innate immune system (IIIS) in response to ischemia-reperfusion injury (IRI) is not well-understood. Here, we studied parallel changes in the generation of key activation products of the proteolytic cascade systems of the IIIS following living donor (LD) and deceased donor (DD) transplantation and evaluated potential assoc

Inserted Between The Painted Glass

This exhibition of new sculptural works by the artist coincides with the launch of a new series of prints by Rosa Barba published by, and only available through Cahiers d’Art; featuring two distinct series of unique Monoprints and two Limited Edition print series. After spending time among the archives of Cahiers d’Art, Rosa Barba drew inspiration from the original copper printing plates featuring

Eligibility for lipid-lowering therapy when applying systemic coronary risk estimation 2 according to guidelines on apparently healthy middle-Aged individuals

Aims: To estimate the proportion eligible for lipid-lowering therapy (LLT) when using the systemic coronary risk estimation 2 (SCORE2) on apparently healthy individuals. Methods and results: Individuals aged 50-64 years were randomly invited to The Swedish Cardiopulmonary Bioimage Study (n = 30 154). Participants with previous atherosclerotic cardiovascular disease (CVD), diabetes mellitus, or chr

Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes

PURPOSE: Gitelman's syndrome (GS) is an inherited autosomal recessive disorder due to loss of function mutations in the SLC12A3 gene encoding the Na-Cl co-transporter (NCCT), the target of thiazide diuretics. The defective function of the NCCT, which normally is expressed in the apical membrane of the distal convolute tubule in the kidney, leads to mild hypotension, hypokalemia, hyperreninemic hyp

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins

Aims/hypothesis: The genetic architecture of model- derived parameters of beta cell function has never been assessed. Therefore, we estimated heritability (h(2)) for model- derived phenotypes of insulin secretion in twins. Methods: Thirty-three monozygotic (MZ) and 23 dizygotic (DZ) twin pairs from the Finnish Twin Cohort Study underwent OGTT (plasma glucose/C-peptide at 0, 30, 60, 90 and 120 min)