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Objective. To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients
Popular Abstract in Swedish Akut pankreatit (bukspottkörtelinflammation) drabbar årligen cirka 300 individer per miljon invånare i Sverige. Dödligheten ligger totalt på cirka 4-7 % och betydligt högre, cirka 20 %, vid svår nekrotiserande pankreatit. Mortaliteten är vanligen associerad med multipel organsvikt och korrelerad till storleken på det inflammatoriska svaret. Underliggande mekanismer för Acute pancreatitis (AP) is a common disorder where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and the remote organ dysfunction still are unclear. The aim of the present study was to further characterize the dynamics and sequence of the immune response in AP, and to determine the cellular origin of the initiating ev
Brottsoffer är ett ord med många konnotationer som har kritiserats för att antyda hjälplöshet och passivitet. Att kategoriseras som brottsoffer är inte alltid välkommet, men medför likväl fördelar, som till exempel möjligheten att driva en rättsprocess och tillgång till stöd och empati. I Sverige är Riksorganisationen Brottsofferjouren Sverige (BOJ) en viktig aktör när det gäller att ge brottsoffeCrime victim is a term with many connotations, which has been criticized for implying passivity and helplessness. To be categorized as a crime victim is not always welcomed. Still, being able to claim status as a victim is also connected to gains, in terms of both financial compensation and emotional support and compassion. In Sweden, Victim Support Sweden is an important actor in supplying help a
BACKGROUND: Sexual conflict theory predicts sexually antagonistic coevolution of reproductive traits driven by conflicting evolutionary interests of two reproducing individuals. Most studies of the evolutionary consequences of sexual conflicts have, however, to date collectively investigated only a few species. In this study we used the annual herb Collinsia heterophylla to experimentally test the
Background: Research involving expressed sequence tags ( ESTs) is intricately coupled to the existence of large, well-annotated sequence repositories. Comparatively complete and satisfactory annotated public sequence libraries are, however, available only for a limited range of organisms, rendering the absence of sequences and gene structure information a tangible problem for those working with ta
This report is the thesis of the research and development project entitled: Development of a Resource Saving Concept for the Establishment of a Climate Suitable for the Storage of Objects Worthy of Preservation in Storerooms at Museums and in Archives. In short: The ZEPHYR project. This work is the result of a research and development project. The aim is to improve the possibilities of using pass
Popular Abstract in Swedish Under det senaste decenniet har föräldrars intresse att välja fristående skolor för sina barn ökat markant. Läsåret 1998-99 gick, enligt Skolverket (1999), drygt 30 000 eller 3 % av grundskolans elever i fristående skolor. Det är emellertid en stor variation mellan landets kommuner. Trots den ringa andel som eleverna i fristående skolor utgör, har diskussionen om skolorAbstract Although the number of children attending private schools in Sweden is less than 4% of those attending compulsory schools, the debate of these schools has been intense. Apart from details as fees and funding, the role of education’ in the Swedish welfare system has been subject of much debate. In spite of the debate, in Sweden there is a lack of knowledge about private schools. The aim of
Introduction: Risedronate, a bisphosphonate for treatment and prevention of osteoporosis, has been shown in several clinical trials to reduce the risk of fractures in postmenopausal women with osteoporosis. The cost-effectiveness of risedronate treatment has previously been evaluated within different country settings using different model and analysis approaches. The objective of this study was to
BACKGROUND: Epithelial cells form the mucosal barriers that prevent the entry of mucosal pathogens, and respond to bacterial infections by producing various host defense molecules. In this study, we examined the inducible nitric oxide synthase (iNOS) response of primary human renal tubular epithelial cells (HRTEC) following infection with uropathogenic Escherichia coli Hu734, or stimulation with l
Guidelines for the treatment of risk factors in diabetes care have been updated recently, due to indisputable results from clinical end-point trials. This study evaluates risk factor control compared with current national and international targets during the period 1996-2003 in Type 2 diabetes (DM2). Patients were registered in primary-care and hospital outpatient clinics using computer software,
Popular Abstract in Swedish Bakgrunden till den här avhandlingen är att man vill utveckla en ny mammografimetod, som utnyttjar ultraljud. När en tunn stråle av kontinuerligt ultraljud träffar en partikel, till exempel en blodkropp, som rör sig, så uppstår en reflektion. Frekvensen av den reflekterade signalen är inte densamma som för den utsända. Signalen har fått ett så kallat Dopplerskift, där fThe motivation to study the kind of problems appearing in this thesis has been ultrasound measurements of flows, from which velocity spectra along lines can be determined. These velocity spectra can mathematically be described by a new non-linear transform, here called the Doppler Spectral Transform (DST). The Doppler spectral transform has a very rich theory, into which some steps are taken here
Objective. Cystectomy combined with pelvic lymph-node dissection and urinary diversion entails high morbidity and mortality. Improvements are needed, and a first step is to collect information on the current situation. In 2011, this group took the initiative to start a population-based database in Sweden (population 9.5 million in 2011) with prospective registration of patients and complications u
A steam methane reforming reactor is a key equipment in hydrogen production, and numerical analysis and process control can provide a critical insight into its reforming mechanisms and flexible operation in real engineering applications. The present paper firstly studies the transport phenomena in an industrial-scale steam methane reforming reactor by transient numerical simulations. Wall effect a
As an open integrated environment deployed with wired and wireless infrastructures, the smart city heavily relies on the wireless-optical broadband access network. Smart home data are usually sent to neighbor optical network units (ONUs) through front-end wireless mesh networks (WMNs) and finally reach the optical line terminal (OLT) for decision making via the passive optical network (PON) backha
Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for year 2020.Among the 63 environmental samples analysed for gamma emitting radionuclides, no elevated levels of anthropogenic radioactivity were observed. All samples (except two samples of lichen) had activity concentrations below the MDA for the natural radionuclides as well as 137Cs, a
In circumpolar regions, coastlines offer rich constellations of diverse resources, and have long been a focus of human habitation. Despite the rich archaeological records that are located along many northern coastlines, there is a relatively limited understanding of the range of factors that informed local settlement strategies. Northern Norway has one of the world’s longest and best-preserved arc
KEY MESSAGE: We show the usefulness of integrating effector screening in a breeding program and in resistance gene cloning, with Phytophthora resistance in the Swedish potato breeding clone SW93-1015 as an example. Phytophthora infestans is one of the most devastating plant pathogens worldwide. We have earlier found that the SW93-1015 potato breeding clone has an efficient resistance against P. in
Background: Early diagnosis of mild lymphedema and treatment are important to prevent its progress. The tissue dielectric constant (TDC), measuring local tissue water in the skin and upper subcutis, has neither been related to the water displacement method (WDM) nor been used to diagnose mild arm lymphedema in patients at risk. Our aims were to evaluate TDC and WDM in combination with palpation, e
Stair-ascending at maximum ability is required during emergency evacuations to reach a safe refuge from deep underground structures. We hypothesized that an ascent can last maximum 5 min at the individual’s maximum step rate (SR), and oxygen uptake (V˙O2) would not reach a stable state. This study explored stair-ascending endurance and some physiological constraints of performance. Eighteen health
