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The transport of biodegradable dissolved organic carbon (bDOC) across land-water boundaries is central to supporting the ecological and biogeochemical functioning of freshwater ecosystems. Yet, we know little about how the generation and supply of terrestrial bDOC to streams and lakes is regulated by the physical, biological, and hydrological properties of the riparian interface. Here, we assessed
Climate change loss and damage research and policy includes biodiversity loss as a non-economic loss and damage. Yet there is scant understanding of what is loss and damage in tropical fisheries and how it is measured. We conduct the first systematic review of loss and damage in fisheries. The study uses a qualitative interpretivist values–based lens to examine fishers’ intrinsic, instrumental, an
Purpose: Oligometastatic gastroesophageal cancer is a clinical entity with no standard treatment recommendation. Treatment with curative intent has recently emerged as an option for selected patients in contrast to the traditional palliative treatment strategy. This prospective study aimed to assess the safety and efficacy of combined systemic and local treatment with curative intent for patients
In many fields connected to architecture and urban design, the term 'resilience' has grown common and tends to stand for a variety of different things. What this paper intends to do is to work with the term under a rather basic understanding - that of systems capable of performing even after being altered. Specifically, this means the extent to which a spatial configuration is sensitive to smaller
The imbalance between the supply and demand of ecological products between society and ecosystems is an important cause of a series of water ecological problems, and water ecological restoration projects aim to improve the above supply–demand relationship by means of inputs from the social side. For this reason, this paper takes the Yellow River Delta region as an example to launch a study on the
Advances in Earth observation capabilities mean that there is now a multitude of spatially resolved data sets available that can support the quantification of water and carbon pools and fluxes at the land surface. However, such quantification ideally requires efficient synergistic exploitation of those data, which in turn requires carbon and water land-surface models with the capability to simulta
This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. Jawaharlal Nehru National Urban Renewal Mission, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holisti
Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl
The curve number (CN) method, developed by the Natural Resources Conservation Service (NRCS), is one of the most widely used approaches worldwide to estimate runoff from rainfall events. However, one of the remaining uncertainties in the method remains whether to apply a frequency-matched or natural data approach for computing the CN from rainfall-runoff data. To address this knowledge gap, this s
INTRODUCTION: Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron-to-neuron transmission along its projections. The lower integrity of the LC-EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains limited. METHODS: We associated diffusion-weighted 7T magne
Background: The six-minute walk distance (6MWD) is a measure of functional capacity and a frequently used endpoint in clinical trials investigating transthyretin amyloid cardiomyopathy (ATTR-CM). We evaluated the clinical utility of the 6MWD by quantifying the gap between the expected and observed physical performance and estimating its determinants. Methods: Outpatients with wild-type (ATTRwt)-CM
Background/Aim: Circumferential resection margin (CRM) has been shown to be a strong predictor of risk of local recurrence (LR) and distant metastases (DM) in patients with rectal cancer treated with total mesorectal excision (TME). However, not all patients with a CRM of zero develop LR or DM. This study aimed to identify factors associated with disease-free survival (DFS) despite non-radical exc
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
Background: The tumoricidal complex alpha1-oleate targets bladder cancer cells, triggering rapid, apoptosis-like tumor cell death. Clinical effects of alpha1-oleate were recently observed in patients with non-muscle invasive bladder cancer (NMIBC), using a randomized, placebo-controlled study protocol. Aims: To investigate if there are dose-dependent effects of alpha1-oleate. Materials and Methods
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes in the composition and metabolism of the mouse gut microbiota. We observed several taxonomic-level changes on day (D)7 post-infection, including
Using firm-level data from 15 European countries between 2011 and 2019, this paper examines the productivity effect associated with the development of Artificial Intelligence (AI), measured by patenting success in AI fields. By making advances in AI and expanding on their knowledge base, companies can optimise production tasks, and improve resource utilisation, ultimately leading to higher levels
Objective: Determine participants’ satisfaction with rehabilitation following total laryngectomy (TL) and investigate associations between dysphagia, voice problems, and possible explanatory variables. Methods: 172 Danish and Swedish participants having received a TL 1.6–18.1 years ago for laryngeal/hypopharyngeal cancer answered a questionnaire regarding satisfaction with rehabilitation following
Under 1900-talet har en stor förändring skett i behovet av att bevara och till-gängliggöra strand. Med storstädernas framväxt och allt livligare fritidshus-bygge bland stränder så har lagstiftare i Danmark, Finland och Sverige sett ett alltmer ökat behov av att skydda stranden trots dess inskränkningar i egen-domsskyddet i respektives stats grundlag och EKMR. Till stor del har länderna gjort en liDuring the 20th century, there has been a significant shift in the need to pre-serve and make beaches accessible. With the growth of large cities and the increasingly active construction of holiday homes along beaches, legislators in Denmark, Finland, and Sweden have seen an increasing need to protect beaches despite the restrictions on property rights in their respective national constitutions an
Lanzarote is an island that is part of the intraplate ocean island volcanism that makes up the Canary archipelago. The Timanfaya eruption (1730-36) was a crucial event in the geological history of Lanzarote. It is considered an anomaly in the volcanic record of the archipelago due to its long eruptive activity, large volume of lava and composition (alkali basalts evolving into tholeiites). The ori
Environmental destruction has long been used as a military strategy in times of conflict. A long-term example of environmental destruction in a conflict zone can be found in Dersim/Tunceli province, located in Eastern Turkey. In the last century, at least two military operations negatively impacted Dersim’s population and environment: 1937–38 and 1993–94. Both conflict and environmental destructio
