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PurposeUganda is one of many African countries struggling to develop adequate healthcare, particularly in regard to local treatment and access to drugs. The purpose of this paper is to contribute to the understanding of how reducing supply-chain complexity can improve health in developing countries. Design/methodology/approachThis study and evaluation included 50 interviews and 27 site visits of t
In vivo microdialysis was used to monitor noradrenalin (NA) release in the rat hippocampus, sensorimotor cortex and amygdala in response to seizures induced by electrical kindling stimulation in the hippocampus. Generalized seizures increased NA output in the hippocampus five-fold above baseline level (as assessed with 2-min sampling periods). The peak value was seen 2 - 4 min after onset of seizu
Periodontitis is an inflammatory disease of the supporting structures of the teeth caused by, among other pathogens, Prevotella intermedia. Many strains of P. intermedia are resistant to killing by the human complement system, which is present at up to 70% of serum concentration in gingival crevicular fluid. Incubation of human serum with recombinant cysteine protease of P. intermedia (interpain A
BACKGROUND: The existence of a link between inflammation in upper and lower airways is well established. It may therefore be assumed that the nose could be used to study inflammatory events in the lower airways. OBJECTIVE: This study aimed to evaluate a lipopolysaccharide (LPS) nasal challenge model by investigating the effect of the CXCR2 inhibitor AZD8309 on neutrophilic inflammation. METHODS: A
Objective To investigate the reproductive and oncologic outcome following robotic radical trachelectomy for early stage cervical cancer. Methods All women with early stage cervical cancer planned for fertility-sparing robotic trachelectomy between December 2007 and April 2015 at two tertiary referral centers in Sweden were identified. Perioperative- and follow-up data was retrieved from prospectiv
The purpose of this study was to characterize the outcome of attempted endovascular intervention in patients with acute embolic or thrombotic superior mesenteric artery (SMA) occlusion. The records of 21 patients during a 3-year period between 2005 and 2008 were retrieved from the in-hospital registry. The first group included 10 patients (6 women and 4 men; median age 78 years) with acute embolic
OBJECTIVES: To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).METHODS: This was a first-in-human, double-blind, randomised, placebo-controlled trial of single and multiple ascending doses of sprifermin from 3-300 μg in knee OA patients scheduled for t
Background and purpose: Recent progress in diagnostics and treatment of metastatic cancer patients have improved survival substantially. These developments also affect local therapies, with treatment aims shifting from short-term palliation to long-term symptom or disease control. There is consequently a need to better define the value of stereotactic body radiotherapy (SBRT) for the treatment of
Background/aims: Congestion is prognostically relevant in cardiac transthyretin amyloidosis (ATTR-CA), but whether congestion has an incremental prognostic value beyond the well-established, congestion-sensitive NT-proBNP is unknown. Therefore, we aimed to comparatively evaluate the prognostic utility of several congestion surrogates over NT-proBNP. Methods: We estimated hazard ratios by Cox propo
In a time marked by growing environmental and societal challenges, where multiple planetary boundaries are being crossed, the way we conduct business practices needs to be rethought. Regenerative business models offer a path towards a more responsible future by incorporating strategies that go beyond net zero and focus on actively restoring the natural and social systems they operate in, creating
Streptococcus pneumoniae is a bacterium of great global importance, responsible for more than one million deaths per year. This bacterium is commonly acquired in the first years of life and colonizes the upper respiratory tract asymptomatically by forming biofilms that persist for extended times in the nasopharynx. However, under conditions that alter the bacterial environment, such as viral infec
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
There is a vast global market of information and communication technologies to be used for educational purposes (ICT4E), both inside and beyond formal schooling. Both the products on offer and the large bulk of academic literature and strategic documents concerned with ICT4E tend to look at these technologies as providing simple technical solutions to complex educational problems. Moreover, the ut
Using a master’s-level human rights program funded by Sweden at Peking University, this case study sought to explore the connection between legal education and social change as influentially advanced by the Law and Development Movement (LDM) and now reflected in various donor-funded law and governance projects in China. To evaluate the program’s underlying assumptions of change, the study examined
Tre grustag undersöktes i nordöstra Tyskland, Kreuzbruchhof, Fritscheshof och Spargelberg. Syftet var att rekonstruera den senaste glaciala aktiviteten i området. Tolkningarna och således rekonstruktionen grundar sig till största delen på sedimentologiska och strukturella undersökningar. Kreuzbruchhof består mestadels av glacifluviala sediment med undantag för några mindre diamikta enheter tolkadeThree gravel pits near Neubrandenburg, NE Germany, were investigated - Kreuzbruchhof, Spargelberg and Fritscheshof. The investigated gravel pits are situated in an undulating kame landscape 150 km south of the Baltic Sea. The aim of this study was to reconstruct the Late Weichselian history (e.g. deglaciation of the Pomeranian ice sheet) of the area. Reconstruction was based mainly on sedimentolog
In Sweden, municipalities are key players in the environmental work to achieve the ambitious energy and climate goals that are set. For Sweden to be able to meet the national environmental targets that are set to 2020 requires that all the actors in Sweden cooperate. For citizens, these goals mean that lifestyle changes are required, which includes consumption, transport and the use of resources.
Abstract In Sweden many older closed municipal landfills lack current safety measures such as bottom liners and contain hazardous materials that are today strictly regulated or banned. Emissions from these pose a threat to health and environment now and in the future, having the potential to contaminate soil, groundwater, surface water and air. Risk for exposure is often increased due to poor doc
The issue of an increasing number of people globally that are adopting unsustainable lifestyles is important because we are destroying the earth’s resources at an accelerating rate. In particular, the pattern of major increasing environmental impact caused by modern food production has the potential to become an important sector for climate change mitigation, but despite the myriad of guides avai
International work aid is a form of social work that historically has been conducted by non-profit organizations. When the commercial volunteer agencies entered the market they did so with a well-known product but with a different organizational form. The for-profit social enterprise does not only aim to create social value but also financial value. The commercial volunteer travels, called volunto
This thesis studies the distribution of accessibility by public transport to retail concentrations and public hospitals in Athens, using spatial autocorrelation analysis based on Local Indicators of Spatial Autocorrelation (LISA) method and Geographically Weighted Regression (GWR). For this reason, the study area was divided in a 300x300 meter square grid of points representing the location point
