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This thesis, which is based on four original papers, deals with human dendritic cells (DCs) in immunity and allergy. DCs play a key role in the regulation of immune responses by acting as the sentinels of the immune system, specialized in the uptake of a diverse range of antigens. These cells migrate to local lymph nodes and become highly efficient in inducing T cell proliferation, thus inducing a

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Popular Abstract in Swedish Storbritannien beslutade sig 1968 för att lämna bakom sig sina koloniala intressen i Persiska gulfen senast 1971. Det brittiska beslutet ledde till att de arabiska gulfstaterna Kuwait, Bahrain, Saudiarabien, Qatar, Förenade Arabemiraten och Oman i sin tur började undersöka möjliga samarbetsformer för att möta en ny tids osäkerhet och hot. Ett stort problem efter det briWhen Britain decided, in 1968, to terminate its official colonial presence in the Persian (Arabian) Gulf as of 1971, this action prompted the Gulf Arab States (Kuwait, Bahrain, Saudi Arabia, Qatar, United Arab Emirates, and Oman) to start the search for a form of partnership that would bring them together to better cope with the insecurity and danger surrounding them and their regimes. A key probl

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Popular Abstract in Swedish Naturliga störningsregimer är viktiga drivkrafter i vegetationsdynamiken hos de flesta skogstyper jorden runt. Att förstå de rumsliga och tidsmässiga egenskaperna i störningarna, såväl i nutid som i förfluten tid, är viktigt bl a vid utformningen av strategier för naturvård, likväl som för att kunna modellera inflytandet av klimat och människans påverkan. I denna avhandNatural disturbance is an important driving force of community dynamics in many forest types around the globe. Understanding spatial and temporal properties of disturbance events in the present and in the past is important in formulating the nature conservation strategies as well as for the modeling of climate and human impacts on forest vegetation. In this thesis I studied wind and fire disturban

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East Prussia was a region populated by people of many different ethnoses, confessions and languages. Initially settled by Germans after the Teutonic Knights had conquered native Pruthenians, it quickly became a melting pot of newcomers from different regions of Europe.East Prussian diversity took a serious hit after the unification of Germany in 1871. The homogenisation policies adopted by the aut

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Popular Abstract in Swedish Denna skrift behandlar marklagring av värme, kyla och kärnavfall.The underground is a vast region, which is, too a large extent, unused by man. It has a large potential as a storage facility due to its vastness and availability. This thesis, which consists of eleven papers and reports, deals with nuclear waste repositories in solid rock and with aquifer thermal energy storage systems. All these storage systems induce multidimensional, time-variable thermo-hydr

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This thesis contributes to the quantitative finance literature and consists of four research papers.Paper 1. This paper constructs a hybrid commodity interest rate market model with a stochastic local volatility function that allows the model to simultaneously fit the implied volatility of commodity and interest rate options. Because liquid market prices are only available for options on commodity

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Magnetkameran är en fantastisk medicinsk bildutrustning som kan producera detaljerade bilder av insidan av kroppen. Förutom bilder av vävnaden och dess struktur så kan magnetkameran också användas till att mäta olika egenskaper hos vävnaden. Om en vävnadsegenskap mäts i varje bildpixel så kan den resulterande bilden (parameterkartan) visas och användas för medicinsk bedömning, vilket kallas för kvThe magnetic resonance imaging (MRI) scanner is a remarkable medical imaging device, capable of producing detailed images of the inside of the body. In addition to imaging internal tissue structures, the scanner can also be used to measure various properties of the tissue. If a tissue property is measured in every image pixel, the resulting property image (the parameter map) can be displayed and u

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Globalization has resulted in more segments and product configurations to meet the needs of various customers in different markets. For manufacturers to keep up, the operations footprint has become more global to source fromthe most appropriate suppliers but also have manufacturing sites in close proximity to the main local markets. The relationship between the products offered, in particular the

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Efter en landreform, som genomfördes i slutet av 40- och i början av 50-talet, blev de flesta taiwanesiska bönderna hemmansägare och odlade marken på små lantegendomar. Denna efterkrigsreform banade väg för en ekonomisk utveckling som väsentligt påverkade och förändrade bondesamhället. När det taiwanesiska jordbruket visade tecken på stagnation på 1970-talet, förändrades böndernas syn på markinnehAfter post-war land reform that took place between 1949 and 1953, most Taiwanese farmers became owner-cultivators working on small landholdings. Post-war land reform paved the foundation for economic development and industrialization, processes that squeezed the agricultural sector and created changes in farming villages. When Taiwanese agriculture showed signs of stagnation in the 1970s, farmers’

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Popular Abstract in Swedish Även om vi i dagens samhälle försöker minska vårt beroende av förbränningsprocesser är förbränning fortfarande vår största energikälla och förväntas så förbli under en lång tid. Därför är det viktigt att effektivisera förbränningsprocesserna för att maximera den energi som utvinns medan utsläppen samtidigt minimeras. En av de oönskade biprodukterna vid förbränning är soThis work has been aimed at developing and applying laser-induced incandescence (LII) for flame soot characterization. The basic principle of LII is rapid heating of the soot particles to temperatures of 3500-4000 K by short laser pulses. Thereby the intensity of the soot incandescence is increased. By detection of this increased incandescence and analysis of the detected signal, the volume fracti

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Popular Abstract in Swedish Denna rättssociologiska avhandling studerar delar av den svenska arbetsmiljöregleringen: arbetsgivarens internkontroll av arbetsmiljön (numera systematiskt arbetsmiljöarbete) och yrkesinspektionens efterkontroll av internkontrollen inom den kommunala sektorns äldreomsorg. Undersökningens syfte är att undersöka om och i vad mån genomförandeprocessens aktörer förstår intThis sociology of law dissertation studies parts of the Swedish work environment regulations: the employer’s internal control of the work environment (nowadays systematic work environment activities) and the labour inspectorate’s auditing of internal control within the municipalities’ care of the elderly. The aim of the study is to investigate whether and to what extent the actors of the implemen

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Popular Abstract in Swedish Sammanfattning Teknik är alltid skapad för en förväntad brukare i ett antaget sammanhang. Inom kommersiell luftfart är dessa antaganden när det gäller design tydliga. Såväl besättning som utrustning är certifierad för en viss typ av operationer i enlighet med flygplanets drifthandbok. Trots denna genomtänkta definition av användare i sitt sammanhang händer det ändå attAbstract Technology is always designed for an assumed user in an assumed context. In commercial aviation, these design assumptions are clearly spelt out in that both crew and equipment are certificated for a specific operation as stated in the aircraft flight manual. Despite this well defined user context, the designed-for and the real contexts often differ enough so that adaptations of working p

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Popular Abstract in Swedish Recenta dödismiljöer framför Brúarjökull-glaciären på Island och Holmströmbreen på Svalbard har undersökts med speciellt fokus på landforms- och sedimentgenes samt kvantifiering av dödisavsmältningen. Fältmätningar, studier av tidsserier av flyg? och satellitbilder samt digitala terrängmodeller är dataunderlaget för kvantifieringen av dödisavsmältningen. SedimentologiskModern dead-ice environments in the glacier forefields of Brúarjökull, Iceland and Holmströmbreen, Svalbard were investigated with focus on landform and sediment genesis, as well as quantification of melting. Field monitoring and studies of multi-temporal aerial photographs, satellite imagery, and Digital Elevation Models (DEMs) provided data for the melting quantification. Sedimentological and ge

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Background: There are several scientific indications that increasing heat due to climate change is going to become the next big societal and scientific challenge. Climate change is recognized as a significant public health threat. However, there is a lack of research on its impacts on occupational safety and health. Aims and Objectives: The general aim of the research presented in this thesis was

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Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell s

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Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime

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Purpose To study the epidemiology of Dupuytren disease and evaluate treatment outcome of collagenase injections using a modified method.Patients and methods Paper I is a register-based study. From the general population of Skåne region (1.3 million) in southern Sweden, we identified all residents aged ≥20 years who had been diagnosed with Dupuytren disease during a 16-year period and identified tr

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Biorefining of lignocellulosic biomass into biofuels and chemicals can help replace fossil resources and decrease anthropogenic greenhouse gas emissions. This thesis is focused on the effects of mixing on the enzymatic hydrolysis of pretreated biomass. Two different types of biomass were studied: softwood (Norway spruce and Scots pine), and the energy grass giant reed. Before enzymatic hydrolysis,

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Art and Music Schools (kulturskolor) are present in about 97% of Sweden’s municipalities, reaching over 400.000 children and adolescents both in activities outside of and in collaboration with compulsory schools. A national policy has never been established for Art and Music Schools, possibly owing to the fact that they are not considered part of the Swedish education system, but instead stem fro

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Drought is predicted to increase in the future due to climate change, bringing with it myriad impacts on ecosystems. Plants respond to drier soils by reducing stomatal conductance in order to conserve water and avoid hydraulic damage. Despite the importance of plant drought responses for the global carbon cycle and local and regional climate feedbacks, land surface models are unable to capture obs