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The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat
This article discusses the advantages of the the Coherence Based Genealogical Method (CBGM), not only as a tool for reconstructing the text of the New Testament, but also for surveying the history of readings and for explaining textual changes. The CBGM promises to detect readings, which have emerged several times independently in the textual tradition. The method is applied to selected examples i
Influences on stratospheric aerosol during the first four months following the eruption of Kasatochi volcano (Alaska) were studied using observations at 10700 +/- 600 m altitude from the CARIBIC platform. Collected aerosol samples were analyzed for elemental constituents. Particle number concentrations were recorded in three size intervals together with ozone mixing ratios and slant column densiti
Small-scale power plants based on the SOFC-GT (Solid Oxide Fuel Cell-Gas Turbine) system are foreseen for future application such as APU units in flight transportation systems or stationary power production. Although these new systems offer high load flexibility and potentially high efficiency, there are several constraints referring to thermal/mechanical stress of the fuel cell as well as to a po
Objectives: The aim of the present study was to analyze the effect of an enhanced systematic dose of nicotine on osseointegration of titanium implants. Material and methods: Sixteen female rabbits received either nicotine ( n = 8) or saline ( n 8) administered subcutaneously via mini-osmotic pumps for 2 months. The pump delivered 6 mg/kg/min of nicotine for the animals in the test group. Blood was
Outlines the development of PhD-education in the Nordic-Baltic area.
A high-quality double-polarization data set for the helicity dependence of the total and differential cross-sections for both gammap --> Npi channels in the Delta region has been obtained in the framework of the GDH experiment. The experiment, performed at the Mainz microtron MAMI, used a 4pi detection system, a circularly polarized photon beam, and a longitudinally polarized frozen-spin target. T
PURPOSE: Nitric oxide (NO) and carbon monoxide (CO) have been suggested to relax smooth muscle by activating soluble guanylate cyclase (sGC), binding to the same site of the enzyme. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) (Cayman Co., Malmö, Sweden) increases the catalytic rate of sGC by binding to an allosteric site. We investigated whether YC-1 can modulate the relaxant responses o
Is the decline of the increasing incidence of non-Hodgkin lymphoma (NHL) in Sweden and other countries a result of cancer preventive measures? The yearly age-standardized incidence of NHL increased significantly in Sweden during 1971-1990, for men an average of 3.2% and for women 3.1%. The corresponding figures for 1991-2000 were -0.8% and -0.2%, respectively. A decline of the increasing incidence
The lower Borgarfjörður region, western Iceland, has been central to the reconstructions of the dynamics and collapse of the Icelandic Ice Sheet during the deglaciation. Here, extensive stratigraphical sections and landforms provide a rare opportunity to study past glacier dynamics in this part of Iceland. Previous studies reveal that a large outlet glacier in Borgarfjörður advanced during the Lat
A sediment sequence from a small forest lake in southwestern Sweden was investigated to explore the effects of forestry and land-use on catchment erosion and delivery of organic and minerogenic matter to the lake. Catchment-scale vegetation changes during the last 1,100 years were reconstructed quantitatively at 50-year resolution using pollen analysis and the Landscape reconstruction algorithm (L
The so-called “dot-compartment” is conjectured in diffusion MRI to represent small spherical spaces, such as cell bodies, in which the diffusion is restricted in all directions. Previous investigations inferred its existence from data acquired with directional diffusion encoding which does not permit a straightforward separation of signals from ‘sticks’ (axons) and signals from ‘dots’. Here we com
Iron can be a growth‐limiting nutrient for phytoplankton, modifying rates of net primary production, nitrogen fixation, and carbon export ‐ highlighting the importance of new iron inputs from the atmosphere. The bioavailable iron fraction depends on the emission source and the dissolution during transport. The impacts of anthropogenic combustion and land use change on emissions from industrial, do
The aldosterone binding in isolated distal convoluted and cortical collecting tubules of renal nephrons and the influence of hormonal induction on the Na, K-ATPase activity in membrane fraction of kidney cortex were studied in 10-day- and 2-month-old rats. No reliable difference in aldosterone-specific binding was revealed (0.26 +/- 0.04 and 0.22 +/- 0.03 fmol/mm of tubule length, respectively, at
