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Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Jana Canavan

Profilområdesmedlem Kontaktinformation E-post: jana [dot] canavan [at] svet [dot] lu [dot] seOrganisation LU profilområde: Mänskliga rättigheter WebbplatsJana Canavans profil i Lunds universitets forskningsportalAndra roller Affilierad Statsvetenskapliga institutionenStatsvetenskapForskningsintressenmänniskor-djur-relationerkritiska djurstudierintersektionalitetmiljöpolitik   Publikationer Visar a

https://www.svet.lu.se/jana-canavan - 2026-06-18

Beskrivning amne 2 kopia

Beskrivning ämne 2  kopia Ämne 2 musik, Estetiska fördjupningskurser Innehåll Totalt omfattar de estetiska fördjupningskurserna 90hp och läses vid Musikhögskolan i Malmö. Varje kurs omfattar 30 eller 60hp. Sammanlagt kan tre kurser väljas, alternativt två om en av kurserna är Musikproduktion 60hp, Arrangering/ komposition 60hp, Körledning/ kördirigering 60hp eller Rytmik 60hp. Om man önskar göra u

https://www.mhm.lu.se/sites/mhm.lu.se/files/beskrivning_amne_2_kopia.pdf - 2026-06-19

Recurrent Streptococcal Pharyngotonsillitis Studies on etiology and treatment

Popular Abstract in Swedish Akut faryngotonsillit orsakas till ca 40 % av betahaemolytiska grupp A streptokocker (GAS) och till ca 10% av andra bakterier. Ca 30% av fallen är virusutlösta och i ca 20% är genesen okänd. GAS är mycket virulenta humanpatogener som förutom svalg- och hudinfektioner även kan förorsaka livshotande tillstånd som ?streptococcal toxic shock syndrome? och nekrotiserande fasIn acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of failures remains largely elusive. The aim of the studies was: 1 To investigate the short- and long-term

How Rigidity and Conjugation of Bidentate Ligands Affect the Geometry and Photophysics of Iron N-Heterocyclic Complexes : A Comparative Study

Two iron complexes featuring the bidentate, nonconjugated N-heterocyclic carbene (NHC) 1,1′-methylenebis(3-methylimidazol-2-ylidene) (mbmi) ligand, where the two NHC moieties are separated by a methylene bridge, have been synthesized to exploit the combined influence of geometric and electronic effects on the ground- and excited-state properties of homoleptic FeIII-hexa-NHC [Fe(mbmi)3](PF6)3 and h

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose

Proteomics and Phosphoproteomics Analysis of Parental and Cisplatin-Resistant Ovarian Cancer Cell Lines Treated with C26A6 and Volasertib

Mot smartare cellgiftsbehandling: Att förebygga behandlingsresistens vid äggstockscancer Äggstockscancer är den dödligaste gynekologiska cancertypen och kräver alltför många liv eftersom tumörer ofta blir resistenta mot behandling – särskilt mot cisplatin, vårt främsta försvar. För att rädda fler liv måste vi förstå hur denna resistens utvecklas och hur vi kan överlista den. I mitt examensarbete Ovarian cancer is the deadliest gynaecologic malignancy, with most patients diagnosed at an advanced stage and facing poor long-term survival. Resistance to cisplatin-based chemotherapy is a major clinical obstacle, yet its proteomic drivers remain poorly defined. In this study, I applied data-independent acquisition mass spectrometry with DIA-NN data processing to analyse one parental and two cis

Skaa15 termin 6 2021

Kursguide - Course Syllabus • • • • Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2019-09- 04 att gälla från och med 2020-08-31, höstterminen 2020. Allmänna uppgifter Obligatorisk kurs inom programmet Konstnärligt kandidatprogram i skådespelarkonst.  Undervisningsspråk: Svenska Därtill kan andra skandinaviska språk och engelska förekomma. Kursens mål S

https://www.thm.lu.se/sites/thm.lu.se/files/2021-01/skaa15_termin_6_2021.pdf - 2026-06-19

Inbjudan 9

Inbjudan.pdf Samordningsansvaret i entreprenad Affärsrättsligt Centrum vid Lunds universitet (ACLU) och Forskningsavdelningen för entreprenadrätt i Stockholm Centre for Commercial Law (SCCL) bjuder in till seminarium om Samordningsansvaret i entreprenadförhållanden är inte närmare undersökt. Under seminariet diskuteras därför tänkbara effekter av att en entreprenör åtar sig beställarens samordning

https://www.aclu.lu.se/sites/aclu.lu.se/files/2023-04/Inbjudan_9.pdf - 2026-06-19

Lund Stem Cell Center FACS Facility

A state-of-the-art multi-colour flow cytometry facility The Lund Stem Cell Center FACS Core Facility is a state-of-the-art multi-colour flow cytometry facility located at BMC B12 and serves all researchers at Lund University and others.Flow cytometry is one of the major methods in the research of cell populations. It has major advantages such as the simultaneous detection of a wide range of parame

https://www.stemcellcenter.lu.se/core-facilities/facs-facility - 2026-06-17