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Recent developments of surrogate assays for human hematopoietic stem cells (HSC) have facilitated efforts at improving HSC gene transfer efficiency. Through the use of xenograft transplantation models, such as nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice, successful oncoretroviral gene transfer to transplantable hematopoietic cells has been achieved. However, because of the l

Background The purposes of this study were (1) to evaluate the wear pattern of the hydroxyapatite-coated "Dual Radius" Omnifit cup, (2) to investigate whether wear is correlated to any demographic or prosthesis-related factors, and (3) to describe micromotion of both the cup and the stem. Patients and methods 154 hips were implanted between 1990 and 1996 and followed for an average of 6 years. Wea

This report describes laboratory and analytical studies of the chloride migration coefficient, D, defined by Tang, the salt frost scaling, the internal frost resistance and the sulphate resistance of SCC that contains increased amount of filler, different types of casting and different air content.

The agar-film and membrane filter methods were used to measure total hyphal length in ten different soils. The former method resulted in values 1.1 to 3.9 times those of the latter. Choice of magnification strongly influenced the results. The value for fungal length found at a magnification of 1250 x was 2 times that found at 800 x or 500 x . The measured mean hyphal diameter was significantly sma

Background Epidemiological studies have, so far, identified factors associated with increased risk for incident or progressive OA, such as age, sex, heredity, obesity, and joint injury. There is, however, a paucity of long-term data that provide information on the nature of disease progression on either group or individual levels. Such information is needed for identification of study cohorts and

A capillary gas chromatographic (GC) method using selected-ion monitoring (SIM) was developed for the analysis of cotinine (C.A.S. No. 486-56-6) in human urine. The method is based on basic extraction of cotinine from 2 ml of urine into dichloromethane. After evaporation of the dichloromethane solution to dryness, 100 microliters of toluene were added, prior to GC-mass spectrometric (MS) analysis.

Mouse mammary tumor virus (MMTV)-like sequences have been found in up to 40% of breast cancer samples but in <2% of normal breast tissue samples from Australian women studied by our group. Screening of a larger and more diverse cohort of female breast cancer samples has now shown a correlation of MMTV-like sequences with the severity (grade) of breast cancer. Thirty-two percent (43 of 136) of fema

Ensuring close control of critical quality attributes (CQAs), such as post-translational modifications (PTMs), in therapeutic monoclonal antibodies (mAbs) is essential for maintaining function and batch homogeneity in large-scale production. Common PTMs include deamidation, fragmentation, oxidation, charge variants, and glycosylations. This study aimed to evaluate CQA variations and correlate the

Academic research has tried to explain the challenges women in executive positions face in connection to work-life balance, glass ceiling and the gender gap in management. However, these previous studies have been made mainly quantitatively. Therefore, this study aims to go beyond the numbers by using a qualitative research approach. This thesis has collected in-depth data through interviews with

The expanding market for psychometric tests faces challenges due to the spread of unvalidated tools. The adoption of popular but scientifically unsupported assessment tools can lead to ineffective hiring and misinformed decisions. This thesis aimed to evaluate and conduct a psychometric analysis of a commercially accessible forced-choice personality test - HumanGuide. Archival data (supplied by Hu

The purpose of this paper is to study how the mindset of an international service firm evolves over time and to research the relationship between internationalization actions and entrepreneurial orientations. The international entrepreneurial orientation of a firm consists of eight dimensions, five of which derive from the Entrepreneurial Orientation concept, and three more are suggested as additi

This thesis explores stigma in regards to access to education for children affected by HIV/AIDS in Vietnam and strategies to overcome stigmatization. This study is based on previous research which claims that HIV-related stigma causes isolation, bullying and social exclusion among affected groups. As a result, Goffman’s theory of stigma was used together with Bourdieu’s theory of capital and Fouca

In the state of Acre, Brazil, there is ongoing land use change, where inhabitants of this part of the Amazonian rainforest practice shifting agriculture. Practicing this type of agriculture is, according to the SKY Rainforest Rescue organization, damaging to forest ecosystems. This organization aims to educate people in how to maintain sustainable agriculture. By monitoring this shift in agricultu

Assisterad befruktning utanför kroppen är en behandlingsmetod som samhället kan erbjuda ofrivilligt barnlösa par. Behandlingen sker antingen genom provrörsbefruktning (IVF) eller genom spermieinjektion (ICSI). Frågor kring fastställande och hävande av faderskap vid assisterad befruktning regleras av föräldrabalken. Enligt huvudregeln i 1 kap. 8 § FB ska en kvinnas make eller sambo som har samtycktAssisted reproductive technology for treatment of infertility, is a treatment that society can provide for couples, who suffer from involuntary childlessness. The treatment is performed either by in virto fertilization (IVF) or by sperm injection (ICSI). The Children and Parents Code regulates the establishment and annulation of paternity due to assisted reproductive treatment. According to the ma

We compared 12-lead electrocardiograms (ECGs) derived with an improved transformation matrix from EASI leads and standard 12-lead ECGs in the detection of acute myocardial ischemia and old infarction (MI). For the ischemia test, we used ECGs of 40 patients recorded prior to and at peak inflation during percutaneous transluminal coronary angioplasty, and for old MI we used test ECGs of 382 non-MI s

Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.

The aim was to confirm a previously defined prognostic index, combining a proliferation marker, histological grade, and estrogen receptor (ER) in different subsets of primary N0/N1 chemo-naïve breast cancer patients.