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Malignant melanoma is a heterogeneous, malignant neoplastic disease, most often originating in the skin. Melanoma is characterized by a high mutational load and has a vastly variable prognosis, depending on disease stage. Genetic aberrations in the mitogen-activating protein kinase (MAPK) pathway are important in melanoma, of which mutations in BRAF and NRAS are the most common. Additionally, recu
Aims: The aim of the study was to compare outcomes in unfractionated heparin (UFH) and bivalirudin-treated patients undergoing primary percutaneous coronary intervention (PPCI). Methods and results: This observational study contained 20,612 PPCI patients treated with either UFH monotherapy or bivalirudin with or without concomitant UFH. Patients with oral anticoagulant or glycoprotein IIb/IIIa inh
Objectives. The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important mediators of inflammation and connective tissue remodelling. The aim of this study was to evaluate if single nucleotide polymorphisms (SNPs) of ALOX5AP confer risk of SSc and/ or SSc-related organ involvement. Methods. Seven SNPs of ALOX5AP (rs17222814, rs17216473
Background: We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and the potential influence of two target temperatures (33 °C and 36 °C) on serum levels of S100. Methods: This is a substudy of the Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial. Serum levels of S100 were measured a posteriori
Measurements of fiducial cross sections for the electroweak production of two jets in association with a Z-boson are presented. The measurements are performed using 20.3 fb(-1) of proton-proton collision data collected at a centre-of-mass energy of = 8 TeV by the ATLAS experiment at the Large Hadron Collider. The electroweak component is extracted by a fit to the dijet invariant mass distribution
Chondroitin sulfate and keratan sulfate in guinea pig costal cartilage, nasal septum cartilage and nucleus pulposus were separated and fractionated by chromatography on CPC-cellulose, ECTEOLA-cellulose and Sephadex G-200 columns. Characterization of the chondroitin sulfates included determination of molecular weight and of the number, and position, of sulfate groups of the disaccharide units. Dist
BACKGROUND: Paralympic sport provides sporting opportunities for athletes with a disability, with the Paralympic Games as the main event. Participation in sport is, however, associated with a significant risk for sustaining injuries and illnesses. Our knowledge of sports-related injuries and illnesses in Paralympic sport is very limited and there are no large-scale epidemiological cohort studies.
Retinitis pigmentosa is a group of inherited retinal degenerative diseases characterized by the loss of photoreceptors and vision for which no effective treatment is available. Several animal models of retinitis pigmentosa are used to elucidate its pathogenesis and to devise therapies. The retinal degeneration (rd1) mouse is one such animal model in which rod-specific phosphodiesterase (PDE) is in
Background: Community-based day centres (CBDCs) for people with mental illness are a common service for both people with an immigrant background and native Swedes. Aim: The aim was to compare CBDC attendees with an immigrant background with attendees who were native Swedes in terms of well-being and perceptions of everyday activities and investigate whether ethnic background could predict these fa
Objective: To explore risk perceptions, sexual practices and healthcare needs among men who have sex with men in the provincial city of Tanga in northern Tanzania. Previous research suggests that HIV/STIs are increasing problems for this population. Yet, few studies have been conducted outside the urban area of Dar es Salaam, which has limited our knowledge about the HIV/STI risk factors and healt
Observables sensitive to the anomalous production of events containing hadronic jets and missing momentum in the plane transverse to the proton beams at the Large Hadron Collider are presented. The observables are defined as a ratio of cross sections, for events containing jets and large missing transverse momentum to events containing jets and a pair of charged leptons from the decay of a Z/ γ∗bo
The issue that this study analyses is the assessment of the standardisation effects on SMEs. To address this problem, the purpose of the study was to explore the motivation of Swedish SMEs to acquire management standards introduced by ISO. To gather data, interviews with 3 Swedish SMEs were conducted. The interviews were transcribed and analysed. The collected data and conducted analysis led to th
Today, breast cancer is the leading cause of cancer related death in women. Early detection of breast cancer relapse presents increased treatment options and better control. Protein biomarkers from plasma are currently measured by state-of-the-art methods like ELISA, which require antibodies with high sensitivity and specificity. Developing such assays is laborious and time consuming. Thus, there
The option between mandatory and voluntary approaches become an unfinished debate in order to reach corporate compliance in the global supply chain on environmental, labour, human rights and anti-corruption issues. In this situation, this thesis proposes an alternative strategy that combines both approaches. For this aim, with the doctrinal and empirical legal approaches, this research scrutinizes
This study examines the implementation of circular economy principles in a company operating in a developing country. Focus is put on the start-up phase of the company, where we seek to understand the entrepreneurial motive behind implementing circular, sustainable practices in the infant stage of the company. Furthermore, the methods used to construct a circular, sustainable business model are in
This study aims to investigate to what extent Donald Trump personifies the characteristics of “right wing populism”. In order to conduct this investigation we have sought to analyze previous research around the terms populism and more precisely right-wing populism. In doing this we hope that it will enable us to distinguish the characteristics of right-wing populism. Once we know the main characte
The purpose of this study was to understand what, according to social workers and people with criminal backgrounds in Panama, contributes to change in criminal behaviour amongst delinquent youth with focusing on projects using football, religion and community as changing means. The empirical data was collected according to micro-ethnographical requirements and consisted of twelve hours of observat
Objective: This review aims to consolidate contemporary literature examining the impact of physical activity (PA) and exercise on sensitisation and pain perception in individuals with chronic non-specific low back pain (cLBP). Methods: A semi-systematic approach was employed, utilising Pubmed and PEDro databases for the period between 2013-2023. Eligibility criteria included randomised control tri
The purpose of the thesis is to analyse how a CSR strategy can create a competitive advantage using the CSR Stage Model in a comparison between MAX and McDonald's. It was found that a majority of consumers value a fast-food restaurant’s CSR work and take that into consideration when choosing between restaurants. Moreover, the survey respondents perceived MAX to be the most sustainable fast-foo
