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In optical genome mapping (OGM), large numbers of individual DNA maps—sequence-specific data series along single DNA molecules—are produced. Such individual maps have to be stitched together in a process called de novo OGM assembly in order to create consensus OGM maps for corresponding regions along the chromosomes. While there are several types of experimental OGM assays, not all of them have de
BACKGROUND Surgical site infection (SSI) following orthopedic surgery impacts patient outcomes. Airborne transmission is one potential route of infection. Despite their high cost and resource demands, modern ventilation systems have shown limited efficacy in reducing SSI rates. This trial investigated the effectiveness of a low-cost air purifier in reducing SSI rates after orthopedic surgery. METH
Objective. While the prevalence of radiographic thumb carpometacarpal (CMC1) osteoarthritis (OA) is well-described, little is known about clinically symptomatic disease presenting to physicians for care. We sought to determine the prevalence of doctor-diagnosed CMC1 OA. Methods. Using health care data from Skane in southern Sweden (population 1.24 million), we identified all adults ages >= 20 year
Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail
Introduction: Complement activation is involved in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atypical hemolytic uremic syndrome (aHUS). Autoantibodies to complement inhibitor factor H (FH), particularly in association with deletions of the gene coding for FH-related protein 1 (CFHR1), are associated with aHUS. Methods: Autoantibodies against FH, factor I (FI) and C4b-bindin
Identification and relative quantification of hundreds to thousands of proteins within complex biological samples have become realistic with the emergence of stable isotope labeling in combination with high throughput mass spectrometry. However, all current chemical approaches target a single amino acid functionality (most often lysine or cysteine) despite the fact that addressing two or more amin
Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by a germline mutation in one of several DNA repair genes, which in the tumors is reflected as microsatellite instability (MSI). MSI+ tumors have been found to carry somatic frameshift mutations in mononucleotide repeats within the coding regions of several genes involved in growth control, apoptosis, and DNA repair, e.g., TGFBRII, BAX, I
Introduction: Few large studies have examined the heritability of venous thromboembolism (VTE). Moreover, twin studies have been suggested to overestimate heritability. The aim of the present study was to determine the heritability nationwide in the general Swedish population using full siblings and half-siblings. Methods: VTE was defined using the Swedish patient register. Full sibling (FS) and h
Background: Domestic violence is a global health problem as well as a violation against human rights. The aim of this study was to explore prevalence and incidence of domestic violence during pregnancy and 1 to 1.5 years postpartum as well as to explore the history of violence among new mothers in the southwestern region of Sweden. In addition, the aim was to explore the association between domest
Context: Test driven development (TDD) has been extensively researched and compared to traditional approaches (test last development, TLD). Existing literature reviews show varying results for TDD. Objective: This study investigates how the conclusions of existing literature reviews change when taking two study quality dimension into account, namely rigor and relevance. Method: In this study a sys
Context: The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids. Objective: The aim of the study was to identify genetic variations in sex steroid-related genes that are associated with serum levels of estradiol (E2) and/or testosterone in men. Design: Genotyping of 604 single nucleotide polymorphisms in 50 sex stero
Historiskt sett har människor byggt sina hus med de material som den omgivande naturen gav. Både vass och lera är två sådana material som förekommer naturligt. Det som bl.a. skiljer dessa material åt är de processer som krävs för att de ska kunna användas som taktäckningsmaterial. Vassen skördas och torkas medan leran bearbetas och bränns för att slutligen bli en användbar produkt. I tidigare svenHistorically, people built their houses with the materials that the surrounding nature gave. Reeds and clay are two such materials occurring naturally. A difference between these materials is the processes required for them to be used as roofing material. Reed is harvested and then dried while the clay is processed and fired to finally become the useful product. In earlier Swedish history roofs we
Korruption är ett begrepp som inte har någon klar definition. Det är många vetenskaper som diskuterar korruption, dock görs detta med delvis olika synvinklar. Denna framställning visar att det finns många olika perspektiv att anlägga på korruptionsproblematiken, perspektiv som dessutom leder till olika slutsatser om problematikens orsaker och verkan. Fler tvärvetenskapliga perspektiv behövs, för aCorruption is a term that has no clear definition. There are many disciplines that discuss corruption, however, this is done with somewhat different perspectives. This essay shows multiple perspectives on corruption issues, perspectives which also lead to different conclusions about the causes and effects of corruption. More interdisciplinary perspectives are needed to be able to work against corr
Denna uppsats ämnar undersöka, analysera och diskutera försvarlighetsbedömningar vid förtal enligt brottsbalken. Uppsatsen söker svaret på hur bedömningen går till samt hur den bör gå till. Undersökningen är begränsad till att omfatta förtal begångna på sociala medier då någon blivit utpekad som brottsling. Uppsatsen avhandlar även aspekten vad som är relevant vid en försvarlighetsbedömning vid föThis paper investigates, analyzes and discusses defense assessments in slander cases, as defined by the Swedish Penal Code. It looks at how assessments currently proceed rela- tive to how they could potentially be handled differently. This survey is limited to cover- ing slander committed on social media when someone has been singled out as a criminal. Our thesis also addresses what is relevant in
Lagen (1993:387) om stöd och service (LSS) till vissa funktionshindrade säkerställer att människor med funktionsnedsättning får anpassat stöd för att kunna leva ett självständigt liv och känna sig delaktig i samhället. Trots detta är diskriminering av ens funktionsnedsättning vanligt och beror på att människor handlar utifrån fördomar där okunskap är den främsta anledningen. I uppdraget av Lunds k
Våld och hot som riktas mot polis, ambulanssjukvårdare och räddningstjänstper-sonal har ökat och blivit grövre under de senaste åren. I uppsatsen undersökts i vilken mån så kallad blåljuspersonal omfattas av det förstärkta straffrättsliga skyddet i 17 kap. 1-5 §§ brottsbalken. De straffrättsliga bestämmelserna omfattar våld eller hot om våld mot tjänstemän och innebär ett utökat straffrättsligt skThreats and violence directed toward the police, fire and ambulance service (Blue Light Staff) has recent years increased and is even of a more serious nature. In this thesis I examine the extent to which the emergency service are covered by the strengthened legislation in Chapter 17 §§ 1-5 of the Swedish Criminal Code (SCC). The criminal law provisions include violence and threats of violence aga
Medlingsinstitutet är en alternativ konflikthantering där parterna ges möjlighet att påverka konfliktens lösning och att återställa lugnet parterna emellan. Transaktioner är inte alltid friktionsfria och situationer kan uppstå där en av parterna vill föra saken inför domstol. Det är inte ovanligt att ombud i dessa situationer hotar om stämning som en skrämseltaktik för att ge sin part en hävstång.The Mediation Institute is a form of dispute resolution alternative to the judicial process where the parties may impact with the process and can influence the outcome, all in the purpose of restoring the calm between the parties. Transactions are not always successful and may result in a dispute where one party is inclined to take the dispute to court. It is not unusual that a part’s lawyer uses
This thesis is conducted in collaboration with Alfa Laval Lund AB. Alfa Laval is a world leading producer of heat transfer, separation and fluid handling equipment. The products help Alfa Laval’s customers to heat, cool, separate and transfer products such as oil, water, chemicals, beverages, starch and pharmaceuticals in over 100 countries all over the world. The hardening competition together wi
Retroaktivitetsförbudet inom skatterätten instiftades 1980 och innebär ett förbud mot att införa skattelag med retroaktiv verkan. Inspirationen kom från straffrätten i vilken principen om förbud mot retroaktiv lag länge hade varit förhärskande. Retroaktivitetsförbudet har med sin ställning som grundlag hög formell status i det svenska rättsväsendet vilket borde borga för att både domstolar och la
This thesis examines the extent to which lobbyists bring democratic value to the policy-formulation and decision-making stages of the EU policy process. It is examined through a single case study of the amendment of Directive 2001/83/EC. By adopting an actor-centered institutionalism perspective and through theoretical discussion on Robert Keohane, Fritz Scharpf and Pieter Bouwen, this thesis bui
