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A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by fragment crystallizable-fragment c
This thesis investigates if it is possible to measure the plunger position in a Ledex 282352-023 solenoid actuator without the use of external sensors. To do this, various different methods, all based on comparing the current response to the applied voltage were evaluated from different categories such as calculation time, reliability and distinct position levels. The method that performed best in
Video capsule endoscopy (VCE), perfomed by ingesting a small vitamin-sized camera pill, was developed over a period of a couple of decades and –since its introduction in clinical practice at the dawn of the millennium– has become an essential tool in the diagnosis and management of small bowel (SB) diseases. At the same time, other fields such as minimally invasive diagnosis of other parts of the
Popular Abstract in Swedish En amfifil molekyl har två delar; en del som dras till olja och en del som dras till vatten. Dessa två delar benämns vanligen huvudgrupp respektive svans. Amfifila molekyler kallas ofta tensider (på engelska surfactants), och är de aktiva beståndsdelarna i bland annat tvättmedel och hårschampo. Amfifila molekyler i vattenlösning formar sig så att vattendelarna dras tillThe formation of highly ordered mesoporous silica materials, using PEO-PPO-PEO amphiphilic triblock copolymers (so-called Pluronics) as structure directing agents, has been studied. The materials are formed through the addition of a silica source to a polymer solution of low concentration (2.5 wt ) under acidic conditions. The products have BET surface areas of approximately 800 m2/g. The unit cel
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl
Popular Abstract in Swedish Biotekniska läkemedel blir allt vanligare och behandlar några av våra viktigaste sjukdomar. Några exempel är insulin för diabetes, tillväxthormon, vacciner, och antikroppar som används i behandling av bland annat cancer, rheumatism och mag- tarmsjukdomar. Dessa läkemedel är proteiner eller peptider som tillverkas i jäst eller djurceller och sedan måste utvinnas ur celleTo design efficient and safe biopharmaceutical production processes, understanding the process and how it is affected by changes in the process conditions is essential. Experimental data form the basis of this understanding which can be enhanced by modeling and simulations of the physical and chemical processes known to control the process. This thesis describes modeling of preparative chromatogra
Deux jeunes femmes projètent de partir en Italie pendant les vacances. La femme brune pense déjà aux beaux jeunes hommes italiens qu'elle pourra rencontrer. La jeune femme blonde, elle, rêve de bronzer au soleil sur la plage. Le jour de leur départ, elles se dirigent vers leur coccinelle verte mais découvrent avec surprise que le coffre contient déjà 2 bagages. Après un long trajet sur une étroite
https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/controle/Etienne.txt - 2026-07-09
The present article describes data from pilot studies with the Swedish versions of the Mindful Attention Awareness Scale (MAAS) and the Kentucky Inventory of Mindfulness Skills (KIMS). The MAAS and two of the KIMS scales, Act with Awareness and Accept without Judgment, were found to correlate in the predicted direction with measures of well-being and emotional distress. The KIMS scales Observe and
