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Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Variability in clinical behaviour and treatment responses reflects its complex underlying pathophysiology. Historically the management has relied heavily on immun
The glycosylation status of IgG has been implicated in the pathology of rheumatoid arthritis. Earlier, we reported the identification of a novel secreted endo-beta-N-acetylglucosaminidase (EndoS), secreted by Streptococcus pyogenes that specifically hydrolyzes the beta-1,4-di-N-acetylchitobiose core of the asparagine-linked glycan of human IgG. Here, we analyzed the arthritogenicity of EndoS-treat
Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen
Project for Doctoral Studies in States of Consciousness (including hypnosis and dissociation) and Parapsychology Project for Doctoral Studies in States of Consciousness and Parapsychology (handledning på svenska eller engelska) As part of programmatic research on states of consciousness and anomalous psychology, my associates and I at the Center for Research on Consciousness and Anomalous Psycholo
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/2017doctoralproject.pdf - 2026-05-27
Project for Doctoral Studies in States of Consciousness (including hypnosis and dissociation) and Parapsychology Project for Doctoral Studies in States of Consciousness and Parapsychology (handledning på svenska eller engelska) As part of a long-term program of research in states of consciousness and anomalous psychology, my associates and I at the Center for Research on Consciousness and Anomalou
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/states_of_consciousness_and_parapsychology.doc - 2026-05-27
Vad din hud behöver i livets olika faser – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Vad din hud behöver i livets olika faser 2026-05-18 Hudens behov förändras genom hela livet. I denna tidslinje får du följa hur huden utvecklas från fem till 85 års ålder och lära dig hur man bäst tar
https://www.vetenskaphalsa.se/vad-din-hud-behover-i-livets-olika-faser/ - 2026-05-25
Municipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementaryMunicipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementary
Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning: Miljögift är mat för bakterier i grundvatten Jag har undersökt bakteriers nedbrytning av organiska miljögifter i grundvatten och intresserat mig för hur den påverkas av gifternas vidhäftning till sand och bakteriernas aktivitet och mångfald. Sådan kunskap kan bidra till att förhindra gifters spridning till t.ex. drickvatten. Many factors can influence the rate of microbial degradation of organic contaminants in aquifers. Some of these factors, e.g. sorption, the presence of dissolved organic matter (DOM), biomass, redox conditions, cometabolism, microbial community composition, and activity of degrading microorganisms, are addressed in the thesis, with the ambition to gain insights for bioremediation in aquifers, and
Geologiska institutionen vid Lunds Universitet har en provpumpningsanläggning på regementet P7s område i Revingehed utanför Lund. Anläggning används av studenter för att se hur man kan arbeta med hydrogeologi i praktiken. I närheten av anläggningen ligger militärens CBRN-område, stora övningsområden samt så finns det uppgifter om att en brandövningsplats tidigare varit belägen i närheten. På anlägIn this study, I have examined a groundwater system located close to a military training camp in Revingehed outside Lund, Sweden. The study includes water analyses of substances in two of three aquifers. The study also shows the effects on the groundwater system when a well located in the third aquifer was pumped with 100 l/min during 3 days. Regarding the activities that has been going on in the
Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces
This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.
Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively
The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr
