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The human hormone-sensitive lipase (HSL) gene encodes a 786-aa polypeptide (85.5 kDa). It is composed of nine exons spanning approximately 11 kb, with exons 2-5 clustered in a 1.1-kb region. The putative catalytic site (Ser423) and a possible lipid-binding region in the C-terminal part are encoded by exons 6 and 9, respectively. Exon 8 encodes the phosphorylation site (Ser551) that controls cAMP-m
Habitat area, forest characteristics, management practices and protected areas have the potential to profoundly impact biodiversity. This is particularly true for specialist species linked to structural complexity and old forest, like the lesser spotted woodpecker (Dryobates minor). This study examines how habitat quality and quantity influence the occurrence of this Near-Threatened species across
OBJECTIVE: Fms-like tyrosine kinase-3 (FLT3), a growth factor receptor normally expressed in hematopoietic progenitor cells, has been shown to have an important role in the development of acute myeloid leukemia due to activating mutations. FLT3 mutations are found in approximately one third of AML patients and correlate with a poor prognosis, thus making the FLT3 receptor a potential therapeutic t
Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to organisms. The detailed mechanism of this enzyme is currently not known, and computational studies are complicated by the fact that different density functional theory (DFT) methods give very different energetic results for calculations involving nitrogenase models. Recently, we designed a [Fe(SH)4H]
The rabbit is a common laboratory animal used for research in dental implants, mainly as a screening model. It has many advantages compared to other laboratory animals. Availability, handling, cost-effectiveness, and early skeletal maturity are a few. For the model’s validity, there need to be similarities to the human. Although there are similarities between human and rabbit anatomy, there are al
Aggrecan, versican, neurocan, and brevican are important components of the extracellular matrix in various tissues. Their amino-terminal globular domains bind to hyaluronan, but the function of their carboxyl-terminal globular domains has long remained elusive. A picture is now emerging where the C-type lectin motif of this domain mediates binding to other extracellular matrix proteins. We here de
Lägg till titel Page 1 of 2 2 Sida 3 av 2 [Name of direct procurement] Dear XXX, We would like to thank you for your interest and your tender in our direct procurement regarding [State item of procurement] . We have received a total of X tenders. We wish to inform you that we have chosen to proceed with your tender and therefore want to sign an agreement with you concerning the tendered product/se
https://www.staff.lu.se/sites/staff.lu.se/files/2023-06/Template%20reply%20to%20the%20awarded%20supplier_230619.docx - 2026-07-07
This page offers a variety of tools and strategies designed to enhance the SI-PASS experience in a virtual environment. Here, you’ll find a range of options for digital collaboration, active learning, and engagement in online SI-PASS sessions. We’ve organised the resources by category:A list of video conferencing and meeting platforms suitable for running SI-PASS sessions remotely.Platforms for on
https://www.si-pass.lu.se/digital-resources-online-si-pass - 2026-07-07
Urothelial cancer of the urinary bladder frequently metastasizes to lymph-nodes, lungs, liver and bone. A taxonomy for molecular classification exists, but it is unknown if molecular subtypes show tropism for different organs. Here, we study 146 patients with de novo metastatic disease or recurrence after curative treatment. We classify primary tumors using two transcriptomic methods and immunosta
Incest är ett brott som under många århundraden bytt både namn och krimi-naliseringsgrunder. Trots att det råder delade meningar huruvida brottet är relevant i dagens lagstiftning finns brottet i 6 kap. 7 § BrB. Brottet har fun-nits ända sedan medeltiden och redan i de tidigaste nedskrivna lagarna finns bestämmelser om incest. Uppsatsens syfte är att undersöka hur brottet incest sett ut i Sverige
Kandidatuppsatsen Hållbarhet inom livsmedelsbranschen är en uppsats på C-nivå vid Lunds universitet. Arbetet svarar dels på hur producerande livsmedelsföretag med säte i Skåne ser på sitt arbete med hållbarhet. Dels kartläggs de skillnader, och likheter, som livsmedelsföretagen har av sitt praktiska hållbarhetsarbete gentemot den teori som forskningsfronten arbetat fram. Avslutningsvis summeras skDue to the historical developments within human society that concern various forms of production, especially food production, sustainability has become an important issue. This Bachelors Essay strives to illuminate the differences between what academic knowledge claims should be done about sustainability, and how small to medium food producers perceive their daily efforts in relation to the three
I samband med äktenskapsskillnad kan frågan om nyttjanderättsersättning aktualiseras om en av makarna tillsvidare bor kvar i en tidigare gemensam bostad. Då det i svensk rätt saknas lagstadgande om nyttjanderättsersättning syftar denna framställning till att klargöra rättsläget, genom att analysera framförallt praxis och doktrin. Avslutningsvis syftar framställningen till att diskutera om tillämpnA question of tenancies compensation can arise during a divorce, if one of two spouses re-mains settled in a former joint home. Due to the fact that Swedish law is missing enactment of this kind of compensation, the purpose of this depiction is to clarify the legal situation by analysing mainly established practice and doctrine. In the conclusion the author will discuss whether the regulations sho
På Kullahalvön i nordvästra Skåne möts man av fantastiska vyer och vacker natur. Kontrasterna mellan berg och hav skapar ett dramatiskt och fascinerande landskap. På halvöns norra sida finns en liten by som heter Skäret. Mitt i byn ligger en obebyggd tomt med utmanande terräng, Skrehällan. Med en höjdskillnad på åtta meter, yvig växtlighet och vidsträckt utsikt har tomten en speciell karaktär som Fantastic views and beautiful nature characterize Kullahalvön, a peninsula in northwestern Scania. The contrast between the mountains and the sea create a dramatic and fascinating scenery. On the northern side of the peninsula there is a small village called Skäret. In the middle of the village is an undeveloped plot of land with challenging terrain, called Skrehällan. With a height difference of
Popular Abstract in Swedish Vid en knäprotesoperation ersätts ledytorna i knäet med en protes gjord av metall och plast. Den vanligaste orsaken till denna operation är artros(ledsvikt. Antalet knäprotesoperationer ökar stadigt och 2009 utfördes 12,700 förstagångsoperationer i Sverige. Resultaten är överlag goda men en allvarlig komplikation som drabbar mellan 1 och 2% av patienterna är bakterieinfThe Swedish Knee Arthroplasty Register (SKAR) was used to identify 478 cases that underwent a first-time revision with exchange or removal of the prosthesis due to infection during the years 1986–2000. 30% of the infections were diagnosed within 3 months from primary operation and two-thirds were diagnosed within 2 years. These cases frequently had a history of wound complication after the primar
Popular Abstract in Swedish I gruppen huvudhalscancer ingår tumörer i övre luftvägar och svalg. Riskfaktorer för huvudhalscancer är rökning och alkoholöverkonsumtion. Under de senaste 20-30 åren har det skett en påtaglig ökning av insjuknandet, 4-5% per år, i det som kallas orofaryngeal cancer. Orofaryngeal cancer utgår från mellansvalget; mandlar, tungbas och mjuka gommen. Ökningen sammanfaller mThe treatment for head and neck squamous cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour stage with neck metastases at the time of diagnosis. The treatment protocol previously comprised rad
Under början av förra seklet skedde en formlig reception av tysk processrätt genom Ernst Kallenbergs verk Svensk Civilprocessrätt i två band. Således kom läran om processföremålet genom 1942 års processreform att läggas till grund för utformningen av den svenska rättegångsbalken (RB). Läran om processföremålet innebär att saken är den omtvistade rättigheten i det bakom-liggande rättsförhållande soAt the turn of the last century, a formal reception of German procedural law took place through Ernst Kallenberg’s work ’Svensk Civilprocessrätt’ in two volumes. Thereby, the German doctrine on the essence of the claim formed the basis for the Swedish Code of Procedure, rättegångsbalken (RB), through the procedural reform of 1942. The doctrine on the essence of the claim holds that the matter cont
Popular Abstract in Swedish Prostata cancer är Sveriges vanligaste cancerform. Många patienter med prostata cancer kan bli botade med kirurgi. I en del fall är kurativt syftande behandling inte möjlig. Dessa patienter behandlas då med hormonbehandling. Hormon behandling går ut på att hämma effekten av det maligna könshormonet, testosteron, som både den normala prostata körteln och tumörcellerna ärHormone refractory prostate cancer occurs when androgen-deprivation therapy (ADT) fails to stop the growth of prostate cancer for any longer. Recent studies point towards a role for neuroendocrine (NE) differentiation in the development of hormone refractory disease. It has been hypothesized that NE-differentiated malignant tumor cells survive during ADT and promote development of androgen-indepen
Parkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. This works very well during the initial treatment period, but unfortunately a majority of the patients develop abnormal involu
Popular Abstract in Swedish En cell är uppbyggd av många olika ämnen som är livsviktiga för dess liv. Polyaminerna – putrescin, spermidin och spermin – är några av dessa ämnen. Celler måste ha tillräckligt mycket polyaminer för att tillväxten ska ske normalt: för lite gör att cellerna slutar att dela sig och för mycket kan omvandla celler till cancer celler. Kunskap om vad polyaminer gör och hur The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. The two main enzymes in the biosynthesis of polyamines are ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC). ODC catalyzes the first step of pol
