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Synthesis of the antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL) increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during lung inflammation. IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. Similar IL-1beta selectivity was
Popular Abstract in Swedish Bakgrund Streptococcus pyogenes, eller grupp A streptokocker, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De orsakar ofta relativt harmlösa och lättbehandlade ytliga infektioner i hals (halsfluss) och hud (svinkoppor) men kan också ge djupare och livshotande infektioner. Dessutom förekommer följdsjukdomar efter infektioner med grupp A streptoPathogenic bacteria often produce potent proteases capable of destroying host tissue thereby providing the bacteria with tools for spreading and nutrient access. This thesis describes how group A, C and G streptococci can acquire surface bound protease activity through an alternative mechanism, namely by binding and activation of the human protease precursor plasminogen. Group A streptococci of c
Popular Abstract in Swedish Proteiner är livsnödvändiga och finns i alla celler. De flesta proteinerna katalysear kemiska reaktioner och kallas då enzymer. Enzymer och proteiner (äggviteämnen) är uppbyggda av aminosyror ihopkopplade till kedjor som kan vara olika långa. Det finns 20 stycken olika aminosyror. Man kan göra en liknelse med ett pärlhalsband tillverkat av 20 olika pärlor, varje pärla mFerrochelatase catalyses the terminal step in heme biosynthesis by inserting a ferrous ion into protoporphyrin IX. The reaction mechanism has in this thesis been studied by mainly crystallographic methods. The structure of ferrochelatase from Bacillus subtilis co-crystallized with N-methyl mesoporphyrin allowed for the first time a characterization of the active site of the enzyme. The structure
Popular Abstract in Swedish Prostatacancer är den bland män vanligast förekommande cancerformen i Sverige. Under 2003 diagnostiserades 9882 nya fall. Sjukdomen drabbar framför allt äldre individer; många män är 70 år gamla eller äldre när de får diagnosen. Sjukdomsförloppet kan vara mycket varierande. Hos många är tumörtillväxten långsam, men sjukdomen kan också utvecklas snabbt. Många patienter lConcentrations of prostate-specific antigen (PSA) and human kallikrein 2 (hK2) were investigated in blood samples that had been obtained from men who were diagnosed with prostate cancer (PCa) decades later. The studies were based on a cohort comprising 22,444 men who, in 1974?1986, were early middle aged and represented a non-PCa-screened population. The results clearly demonstrate a very strong c
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-migraine efficacy. One remaining question is where do these blockers act? We hypothesized that the trigeminal ganglion could be one possible site. We examined the binding sites of a CGRP receptor antagonist (MK-3207) and related this to the expression of CGRP and its receptor in rhesus trigeminal ganglion. Pituitary
Popular Abstract in Swedish Avhandlingen utgörs av studier av smärtupplevelse i olika befolkningsgrupper. I fokus för analyserna står smärtans totala utbredning. Ett beteendepsykolo-giskt perspektiv har applicerats på psykosociala aspekter av betydelse för att hantera den kroniska smärtan. Alla studier har genomförts på urval av Malmöbefolkningen. Bakgrund. Smärtrelaterad arbetsoförmåga är ett foMusculoskeletal pain-related vocational dysfunction is a major public health problem. The solution is beyond the scope of biomedicine, but the problem could well be analyzed in the complementary, cognitive-behavior psychological frame of reference. In order to better prevent the development of pain-related dysfunction: The sociodemographic milieu of dysfunctional chronic pain patients was examined
Numerous different bioreactor systems are applied for hydrogen production by dark fermentation. Thermophilic fermentations are gaining an increased interest due to the high hydrogen yields associated with them. In order to reach the best thermophilic fermentation system, 2 types of bioreactors, a trickling bed and a fluidized bed system, were constructed and operated under similar conditions. Both
The galectins are known to be able to recognize and cross-link beta-D-galactopyranoside-containing glycoconjugates as a result of presenting multiple binding sites. This review summarizes efforts in our group for the last ten years towards low-molecular weight chemically modified carbohydrate derivatives. In addition to providing an avenue for improved affinity and galectin-selectivity, we have fo
Mushrooms have already been proven to be a reliable and versatile material for various design purposes. For my project I am experimenting with expanding the possibilities of mushroom matter as a building material and also contemplating mushroom as a metaphor for local culture in relation to Lithuanian people as a whole. Developing mushroom matter into a building material designed for a specific si
Metal contamination of lakes can bring negative effects to aquatic biota, and to the general health of the ecosystem. Urban discharge is a known source of common metals. In cold regions, snow disposal sites further enhances the risk of contaminating recipient lakes, due to accumulation of pollutants. The importance of this source is poorly known and is further investigated in this study. Metal con
This thesis involves creating an extending an application called “Var f-n är bussen?” (something like “Where the hell is that bus?”) for the company Trivector Systems in Lund. “Where the hell is that bus?” is an application for smartphones that will show departure time for buses from a chosen bus stop, linepath, bus stops and buses for a chosen bus line and the next bus stops and departure time fr
A local-scale Gaussian dispersion-deposition model (OML-DEP) has been coupled to a regional chemistry-transport model (DEHM with a resolution of approximately 6 km x 6 km over Denmark) in the Danish Ammonia Modelling System, DAMOS. Thereby, it has been possible to model the distribution of ammonia concentrations and depositions on a spatial resolution down to 400 m x 400 m for selected areas in De
Social networking sites have become platforms of strategic importance to brand communication. However, to date, little is known about how brands should communicate with overstimulated digital natives on these platforms, especially concerning the language style they should use. In light of the phenomenon of brands increasingly adjusting to a human style of communication, this qualitative study take
Popular Abstract in Swedish Den viktigaste uppgiften inom den kliniska cytologin är att påvisa cancerceller i olika typer av cellprover. Många olika cancertumörer sprider sig till lungsäcken och bukhålan och ger då ofta upphov till vätska (exsudat) som innehåller cancerceller. Ofta kan cancerdiagnosen ställas på grundval av cellernas utseende men detta är inte alltid möjligt, eftersom cancercellerClinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. It is the most promising universal indicator of malignancy and the project focuses o
Protein drugs, such as therapeutic antibodies, are complex and require careful handling to maintain their efficacy and quality. Stress factors in hospitals, like temperature variations and mechanical shocks during transport, may negatively impact the stability of protein drugs (e.g. various monoclonal antibodies). The pharmaceutical industry possesses extensive knowledge about their product formul
Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with an abasic (AP) site base excision repair intermediate. For 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining step in the initiation of 8-oxoguanine (8-oxoG) repair in DNA. Evolution has led OGG1 to use a product-assisted catalysis approach, where t
Prostate-specific antigen (PSA), produced by prostate cells, provides an excellent serum marker for prostate cancer. It belongs to the human kallikrein family of enzymes, a second prostate-derived member of which is human glandular kallikrein-1 (hK2). Active PSA and hK2 are both 237-residue kallikrein-like proteases, based on sequence homology. An hK2 model structure based on the serine protease f
JUNI 2012 Nyhetsbrev från stiftelsen Forska Lund - Insamlingsstiftelsen för forskning och utbildning inom Lunds universitet Tack för alla bidrag Ett stort tack för alla fantastiska bidrag som vi har fått in till forskningen vid Lunds universitet via stiftelsen Forska Lund. I skrivandets stund är det 80 000 kronor fördelat på 58 gåvor under 2012. Väldigt få kan på egen hand åstadkomma stora skillna
https://www.lu.se/sites/www.lu.se/files/nyhetsbrev_juni_2012.pdf - 2026-07-11
