Filtyp
Abstract Fatty acids mobilized from triacylglycerol stores are a major energy source in humans. Mobilization occurs through the consecutive action of three lipases: adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). Whereas ATGL and MGL only hydrolyse tri- and monoacylglycerols, respectively, HSL has a broad substrate range and hydrolyses cholesterol
Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli
Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. Classical reaction engineering was combined with genetic engineering to improve the production of chiral alcohols and kinetic resolution of racemic ketones with high enantiomer
Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes are encoded by the nuclear genome, a tightly regulated and coordinated nuclear-mitochond
This dissertation examines how young people with Kurdish backgrounds form their identity in Sweden with regards to processes of inclusion and exclusion. It also sheds light on the ways these young people deal with ethnic discrimination and racism. Further, the study outlines the importance of these social processes for the discipline of social work and the ways social workers can work with disadva
Background: The Southern Swedish Malignant Melanoma (SSMM) research team is a truly cross functional group with members from oncology, clinical, surgery, bioinformatics, proteomics, and genomics initiatives. The SSMM’s objectives and goals are to develop, build and utilize cutting edge biobanks and OMICS platforms to better understand disease pathology and drug mechanisms. Within the research team
Populärvetenskaplig sammanfattning: Under året 2001 kom forskare i hela världen överens om att globala klimatförändringar existerar och att människliga aktiviteter har påverkat dem, framförallt genom utsläpp av koldioxid (CO2). Kyoto Protokollet är en global överenskommelse som kräver en minskning av CO2 utsläpp (med 1990 som basår) och fem andra växthusgaser med 5% fram till 2012. Ett sätt som näIn 2001, the Intergovernmental Panel on Climate Change approved human impact (mainly through the emission of carbon dioxide (CO2)) on global warming. The Kyoto Protocol is a global contract that proposes the reduction of CO2 and five other greenhouse gases by 2012 to at least 5% below the level of 1990. One reduction strategy included in the Protocol is the Clean Development Mechanism (CDM). It su
Med den globala uppvärmningen förutspås klimatet i arktiska och subarktiska miljöer förändras påtagligt. Enligt IPCCs senaste rapport kan både temperatur och nederbörd öka dubbelt så mycket som det globala genomsnittet, och störst ökning väntas under vinterhalvåret. Många känsliga ekosystem och miljöer kommer med stor sannolikhet att påverkas redan vid små förändringar. Ett exempel på sådana miljöThe on-going global warming is projected to have large impacts on the arctic and subarctic environment. Especially vulnerable are ecosystems with narrow climatic envelopes and with small possibilities of adaptation. An example of this is the palsa mires, subarctic mire complexes with patches of permafrost. Palsas are peat mounds with a frozen core, formed by the expansion and upheaval of the segre
Globalization has since the 90s played a big part in the way companies look at their business and strategic developments. Acting on a global scale introduces a new complexity when it comes to running a business successfully. Alfa Laval being a global player within their product segments, experiences this complexity with production facilities as well as employees spread around the globe combined wi
En vegetationskarta och en digital höjdmodell har gjorts över ett 54 km2 stort område beläget på Svalbards västkust, vid Isfjorden. Vegetationskartan är baserad på flygbilder och en undersökning gjord i fält under juli månad 1994. Systemet som användes vid klassificeringen av de olika vegetationstyperna är utarbetad av Elven et al. (1990) för en liknande studie i Gipsdalen på Svalbard. Vår vegetatA vegetation map and a Digital Elevation Model has been generated over a 54 km2 area situated at the western coast of Svalbard, at the Isfjorden fiord. The map is based on aerial photographs and a field survey made during the summer of 1994. The classification system used is described by Elven et alia (1990), for a similar study in Gipsdalen in the inner part of Isfjorden. The classification of th
Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.
We have measured the uptake capacity of nitrogen (N) and potassium (K) from different soil depths by injecting N-15 and caesium (Cs; as an analogue to K) at 5 and 50 cm soil depth and analysing the recovery of these markers in foliage and buds. The study was performed in monocultures of 40-year-old pedunculate oak (Quercus robur), European beech (Fagus sylvatica) and Norway spruce (Picea abies (L.
Abstract in UndeterminedThis study deals with a current problem of urban human-biometeorology on the micro-scale, which becomes more important due to the future increase of severe summer heat in Central Europe. The impact of street design parameters on the thermal comfort of citizens is analysed in an experimental way for typical summer conditions in Central Europe. The investigation is focused on
The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. Several Q compounds have reached clinical trials and one compound, laquinimod, is currently in phase III clinical trial for relapsing-remitting multiple sclerosis. The Q
The aim of this study is to extend the traffic safety assessment concept to also include normal road user behaviour, thus not only exceptional behaviours such as accidents and serious conflicts. The goal is to provide a framework for a more thorough description and analysis of safety related road user behaviour in order to better understand the traffic safety processes. The traffic safety process
The objectives of this thesis are to find a common ground for business and environmental interests and to evaluate the potential of Environmental Management Systems (EMSs) as transition tools to lead towards a greener economic paradigm. For these purposes it was assessed, which implications EMSs have for the competitiveness of small and medium sized enterprises (SMEs) within the first three years
Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of bone turnover (BTMs) have shown some degree of fracture predictability. There is also a correlation b
