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Background: Since the cloning in 1990 of cDNA corresponding to mRNA transcribed at the blood-group ABO locus, polymorphisms due to ethnic and/or phenotypic variations have been reported. Some subgroups have been explained at the molecular level, but unresolved samples are frequently encountered in the reference laboratory. Results: ABO blood grouping discrepancies were investigated serologically a

The aim of the project has been to elucidate molecular events leading to amyloidosis in Hereditary Cystatin C Amyloid Angiopathy (HCCAA) patients, to enable simple diagnosis of the disease and with the ultimate goal to understand the amyloid formation process in detail, in order to develop inhibitors to the process. At the DNA level, a point mutation segregating with HCCAA was identified in the cy

En ny europeisk studie granskar hur allmänheten i sex länder ser på organtransplantationer och postnatala genetiska test. Det rör sig om Cypern, Österrike, Tyskland, Frankrike och Sverige. I undersökningen framkommer att de tillfrågade personernas funderingar följer två övergripande spår: Här finns å ena sidan tankar om den medicinska utvecklingens potential, å andra sidan reflektioner rörande desRecent developments in the field of biomedicine do not only constitute a challenge for the health care systems of modern societies. They also have a profound impact on the core concepts of individual and collective life. The corresponding changes of individual and collective identities take place within the framework of different historically shaped national conditions and traditions. This leads t

Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)

Popular Abstract in Swedish Framtida klimatförändringar påverkas till stor del på människans utsläpp av CO2, samt av klimat- och CO2-relaterade återkopplingar genom kolcykeln i både landbaserade ekosystem och hav. Landbaserade ekosystem tar för tillfället upp omkring 25% av de antropogena utsläppen av CO2 från förbränning av fossila bränslen och markanvändning, men att tillskriva vilka mekanismer The nature of future climate change will depend on anthropogenic emissions of CO2, as well as climate- and CO2-mediated feedbacks through carbon (C) cycling in both terrestrial ecosystems and oceans. Terrestrial ecosystems remove presently about 25% of the anthropogenic CO2 fossil-fuel and land-use change emissions, but to attribute which mechanisms cause this uptake, and the key regions where it

The Zeeman interaction in low-dimensional III-V semiconductor nanostructures is studied. The effective g-value of bulk InGaAs is measured by two different spin resonance techniques. Experimental conditions were found to control the Overhauser effect, thus enabling a highly accurate determination of the g-value, g* = -4.070 ± 0.005, being a prerequisite for theoretical modeling of low-dimensional

Popular Abstract in Swedish Därför får man sockersjuka (Felix Mulder, 6 år): ”Det är inte bra att äta för mycket socker. Socker är vasst och skär sönder blodkropparna. Då kan man inte göra insulin och man blir sjuk.” Islet amyloid polypeptide (förkortat: IAPP) är ett medelstort äggviteämne - peptid - som upptäcktes 1986 av Per Westermark i Uppsala. Denna upptäckt har en intressant bakgrund. Det hIslet amyloid polypeptide (IAPP; also named ”amylin”) is a member of the calcitonin superfamily of peptides, displaying the closest structural relationship to the neuropeptide calcitonin gene-related peptide (CGRP). It is expressed in islet beta-cells and forms islet amyloid in type 2 diabetic patients. IAPP may restrain release and peripheral actions of insulin. Thus, IAPP has been implicated in

Popular Abstract in Swedish När vi ser oss omkring i naturen är det lätt att överväldigas av den otroliga variationen i olika former, färger och mönster som förekommer. Var kommer all denna variation ifrån? Samma fråga ställde sig Charles Darwin för mer än 150 år sedan – svaret publicerade han 1859 i sin bok ”Om arternas uppkomst”. Evolution är den process som genom selektion gynnar vissa egenskapOur knowledge of the evolutionary potential of traits involved in different selective episodes, especially in natural populations, is still limited. This is true for questions such as the genetic basis and inheritance of traits, how natural and sexual selection acts on them, and how selective conflicts influence the evolutionary response to selection. In my thesis, I investigate these questions, u

The red admiral (Vanessa atalanta) is a migratory butterfly that can be found in North America, North Africa, Europe and some parts of Asia. In Europe the main part of the population spend winter in the Mediterranean region and the following spring leave this area to breed further to the north. At least one new generation is then produced in the summer region before they return to the south again

The gene fusion technique is widely used in protein engineering and in this thesis it constitutes the basis of both the construction of artificial bifunctional enzymes and the display of two novel peptides. Artificial bifunctional enzymes have been used as model systems in the studies of native multifunctional enzymes and proximity effects within these complexes. Two various constructs are descri

Organic substrates for pelagic bacteria are derived from dissolved organic carbon (DOC) in the water column that originates either from primary production from within the lake itself (autochthonous), or import of organic matter from the terrestrial watershed (allochthonous production). This thesis addresses the utilization of allochthonous versus autochthonous carbon (C) sources by lake bacteriopl

A strain of an alkaliphilic bacterium Bacillus halodurans was isolated from a water sample in Lake Shalla, a soda lake in the Ethiopian Rift Valley. From the culture of this isolate, B. halodurans S7, a xylanase which is active in a wide range of pH, with an optimum at about 9-9.5 was purified. When assayed at pH 10, the enzyme was optimally active at 70 ?C. The xylanase was free from any associat

The primary aim of the research project is to analyse the potential for the application of lidar and fluorescence techniques in building investigation, and also to establish a scientific remote-sensing method for surveying and analysing the historical facade that is non-destructive and can be used in-situ. The fluorescence lidar method uses point-monitoring and scanning of areas that can provide m

Cerium dioxide, or ceria, is a chemically stable oxygen ion conducting material with a capacity to store and release oxygen, and is therefore extensively used in combustion catalysts. The Cu-Ce-O system has been identified as one of the most active catalysts for the combustion of carbon monoxide. To study the catalytic oxidation of CO, we have synthesised model CuO_x/CeO₂ cata

Popular Abstract in Swedish Finkorniga moräner betraktas ofta som problemjordar inom anläggningsbranschen beroende på jordarnas känslighet för förändringar i vatteninnehåll och för deras tjälegenskaper. I dagsläget används endast en begränsad mängd finkorniga moräner i anläggningsbyggande. Huvudmålet med denna avhandling har varit att öka kunskapen om dessa jordars egenskaper och att finna/utvecklFine-grained soils are often regarded as problematic soils in earthworks because of their water- and frost sensitivity. Only limited amounts of fine-grained tills are used as earthwork material today. The main objective of this thesis is to improve the knowledge of how to use and also treat a fine-grained till, so that a greater amount can be utilised as earthwork material. To achieve an increasin

Popular Abstract in English Antonie van Leeuwenhoek is known as the father of microbiology, because he made the first microscopic observation of bacteria in human history, published in 1683. For the naked human eyes, bacterial cells are too small to observe, and the development of microscopy techniques has since then been fundamental for examining bacterial cells. Recent advances in visualizing toCoiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. The best studied examples of the latter are crescentin in Caulobacter crescentus that determines the curved cell shape, and FilP (filament forming-p

Intramyocellular triacylglycerol (TG) is an important energy store, and the energy content of this depot is higher than the energy content of the muscle glycogen depot. It has recently been shown that the mobilization of fatty acids from this TG pool may be regulated by the neutral lipase hormone-sensitive lipase (HSL). This enzyme is known to be rate limiting for intracellular TG hydrolysis in ad