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The constant need for higher performance and more advanced functionality has made the design and manufacturing of modern electronic chips highly demanding. Moreover, the use of smaller transistors in modern chips has increased their sensitivity to aging and faults, hence the need to constantly monitor the correct operation of these chips. To address the challenges and requirements, it has become c
Shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. In order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cel
Popular Abstract in Swedish Många fåglar flyttar regelbundet långa sträckor mellan sina häckningsplatser och vinterkvarter. På rastningsplatser längs flyttningsvägen stannar fåglarna upp och äter, för att lagra upp de energi-lager de behöver som bränsle när de flyger. Vissa flyttfåglar lägger på sig så mycket bränsle (energi), mestadels som fett, att de dubblar sin kroppsvikt. Det lagrade bränslet
Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c
Load problems in electricity markets occur both on the supply and demand side and can have technical, economic and even political causes. Commonly, such problems have been solved by expanding production and/or distribution capacity, importing electricity or by load management. Load management is a techno-economic measure for harmonizing the relations between supply and demand sides, optimizing pow
With the increased availability of computational resources, the past decade has seen a rise in the use of computational fluid dynamics (CFD) for medical applications. There has been an increase in the application of CFD to attempt to predict the rupture of intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, to date, no consistent methodology
Nature-based tourism in the fragile Arctic environments is emerging as a major environmental concern, mainly due to extreme seasonality in these locations, the lack of suitable infrastructures and planning, and its interference with fragile ecosystems. In Iceland tourism has increased exponentially during the past decades, causing more environmental impacts on the country's natural recourses. Hiki
The work presented in this thesis has aimed to improve the knowledge about the groundwater occurrence in different geological conditions in Mozambique. The main focus in this study has been on the understanding of hydrogeological conditions in area with little background information by use of geophysical investigation. The lack of background information is a problem in many countries because the
The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac
Background: Prostate-specific antigen (PSA) measurement in midlife predicts long-term prostate cancer (PCa) mortality among white men. Objective: To determine whether baseline PSA level during midlife predicts risk of aggressive PCa in black men. Design, setting, and participants: Nested case-control study among black men in the Southern Community Cohort Study recruited between 2002 and 2009. A pr
Background: There are several scientific indications that increasing heat due to climate change is going to become the next big societal and scientific challenge. Climate change is recognized as a significant public health threat. However, there is a lack of research on its impacts on occupational safety and health. Aims and Objectives: The general aim of the research presented in this thesis was
Background: Regimens based on ibrutinib alone and lenalidomide and rituximab in combination show high activity in patients with relapsed or refractory mantle cell lymphoma. We hypothesised that the combination of all three drugs would improve efficacy compared with previously published data on either regimen alone. Methods: In this multicentre, open-label, single-arm, phase 2 trial, we enrolled pa
Background: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large international database to determine recurrence patterns and overall survival (OS), as part of a wider project to issue recommendations on FU protocols. Objective: To analyse associatio
Popular Abstract in Swedish Hur gick det till när det svenska riket expanderade norrut och införlivade Hälsingland? Denna bok är uppställd som en generalhypotes över denna långt utdragna process, som tar sin utgångspunkt i den samhälleliga kollaps som är skönjbar under 500-talet. De inhemska maktstrukturer som gradvis byggdes upp efteråt kom under medeltidens inledande århundraden att få känna på In which way did the power structures of central Sweden expand into the territories north of the forest Ödmården during the Middle Ages? This text reads like a general hypothesis for this process, which attempts to incorporate all relevant elements in the Medieval landscape of power. The study area chosen is the province of Hälsingland. The chronological take-off is the 6th century AD, when settle
Aim: The Eurasian otter (Lutra lutra) is a flagship species for global freshwater ecosystems. As one of the most widely distributed Palearctic mammals, the otter used to inhabit most provinces in China. However, after decades of relentless hunting and habitat degradation, the Sanjiangyuan Region is now one of last strongholds for this species in China. Currently, there still remains an enormous kn
In Europe, willow (Salix spp.) trees have been used commercially since the 1980s at a large scale to produce renewable energy. While reducing fossil fuel needs, growing short rotation coppices (SRCs), such as poplar or willow, may have a high impact on local air quality as these species are known to produce high amounts of isoprene, which can lead to the production of tropospheric ozone (O3). Here
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. Study I addresses the challenges associated with adapting CRISPR-Cas9 to the mitochondrial environment, and identifies
The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh
