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Popular Abstract in Swedish Östersjön är ett av världens största brackvattenhav och har stora miljömässiga problem orsakade av övergödning och varmare klimat. Det mer saltrika bottenvattnet som flödar in genom en smal förbindelse med Nordsjön skiljs från ytvattnet av en haloklin, vilket förhindrar ett utbyte av syre mellan de två vattenmassorna. Tillförsel av näring och ett varmare klimat leder tiThe Baltic Sea is one of the largest brackish water bodies in the world and is suffering extensive environmental issues caused by eutrophication and warming climate. A halocline in the water column divides more saline bottom water fed by inflows through the narrow connection with the North Sea from the surface waters and inhibiting exchange of oxygen between the two water masses. With the nutrient

This thesis is a study of social life, addressing issues concerning how and by what means people meet in urban public space. The main aim of this thesis is to is to investigate how certain artefacts and architectural features support the formation and temporal stabilisation of heterogeneous clusters and collectives, and thus, in order to the development of conceptual tools that can contribute to a

The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est

Varje cell har ett membran som skapar en gräns mot omvärlden och skyddarcellen. Men cellen måste alltjämt utbyta viktiga molekyler med omvärlden för attöverleva. Därför finns specialiserade proteiner, som sitter i membranen och utgörportar i denna barriär. Denna avhandling fokuserar på två membranproteiner, enprotonpump och en jonkanal.Varje dag i våra liv använder vi hjärnan, muskler och hjärtat.NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. In the hydrophilic domain electrons from NADH oxidation are transported via a wire of iron-sulfur

Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. In the clinical setting, disease management has heavily relied on the sole targeting of malignant cells but, except

The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. The movement of CSF from the PVS and through the brain is dependent on the polarised expression of aquaporin-4 (AQP4) at astrocyte endfe

Human activities have a huge impact on the carbon cycle by modifying the landscape. Vegetation cover changes attributed to forest clearance and the expansion of agricultural land increases soil erosion, organic matter and other nutrient delivery from terrestrial to aquatic ecosystems. Long-term records of environmental variation at centennial to millennial time scales are essential for the assessm

In blood, the oxygen-transporting protein hemoglobin (Hb) governs the oxygenation of cells and tissues. Naturally, this protein has claimed a place in the center of the research field of artificial oxygen therapeutics. Such Hb-based products have used cell-free Hb purified from human, bovine, invertebrate, or recombinant sources to create hemoglobin-based oxygen carriers (HBOCs). However, administ

Popular Abstract in Swedish Bilsäten har genomgått en kontinuerlig utveckling ända sedan de först beskrevs år 1885. På den tiden kunde man läsa om vadderade läderbänkar, monterade på stora fjädrar, fastsatta i chassit på ”hästlösa vagnar”. När polyuretanskum först började tillverkas på 1950-talet introducerades de snabbt i bilsätena och dessa genomgick stora förbättringar. Skummen utgör idag en stAutomotive seating has been under continous development since it was described for the first time in 1885. At that time one could read about a “padded leather bench seat sitting on springs mounted directly to the frame of a horse-less carriage”. With the development of flexible polyurethane foam in 1950-1960 the seats were considerably improved and the traditional springs were eventually replaced

Popular Abstract in Swedish Polymerelektrolytbränslecellen utmärker sig som en framtida effektiv och miljövänlig kraftkälla för bland annat fordon. Den bakomliggande teknologin är dock komplex och grundar sig till stor del på material och komponenter som kräver ytterliggare utveckling. En av de största hindren för bränslecellsteknologins utveckling är kravet på nya, långlivade och billiga polymermThe proton exchange membrane fuel cell (PEMFC) is currently emerging as an efficient and environmentally friendly power source. The technology is very complex and relies ultimately on materials and components which need further development. One of the major hurdles for advancing the PEMFC technology is currently the demand for new durable low-cost polymeric membranes that will allow fuel cell oper

Background: The absence of Epithelial Membrane Protein 3 (EMP3) on red blood cells (RBCs) underlies the MAM-negative (MAM−) phenotype. EMP3 is a ubiquitous protein found at low levels in most tissues but with higher expression in hematopoietic cells. Low levels of CD44 are a signature of MAM− RBCs due its proposed physical interaction with EMP3, indicating that EMP3 stabilises CD44 in the membrane

This report consists of five tasks which were designed to gain an in-depth and broad understanding of the state-of-the-art on research, policy and practice on integration of refugees and host community relations. This was undertaken to form a foundation upon which to build Work Packages focusing on the field work (WP 3 and 4), the development of a refugee and host community toolbox (WP5 and 6) and

Background: Emerging evidence suggests that artificial intelligence (AI) can increase cancer detection in mammography screening while reducing screen-reading workload, but further understanding of the clinical impact is needed. Methods: In this randomised, controlled, parallel-group, non-inferiority, single-blinded, screening-accuracy study, done within the Swedish national screening programme, wo

Vegetation is the major source of volatile organic compounds (VOCs) in the atmosphere, which affect both air quality and climate. Long-term ecosystem-level data on biogenic VOC (BVOC) emissions, however, are limited. This is especially true regarding the impacts of landscape-scale disturbances like clear-cutting on the short-term and longer seasonal-scale emissions of boreal forests, particularly

BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina

Controlling the surface morphology and chemical interaction is necessary for the development of advanced quantummaterials, particularly in low-dimensional systems. As the research increasingly focuses on miniature and nanoscaletechnologies, a fundamental understanding of localized or interface states becomes essential for successful integrationinto functional devices. This thesis investigates atom

Background: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuro

Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a