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Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress
Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e. unfolded protein response (UPR), play key roles in proteostasis but their involvement in t
A Solar Collector Model for TRNSYS Simulation and System Testing
Surface energy exchange and land-atmosphere interactions of Arctic and subarctic tundra ecosystems under climate change
Popular Abstract in Swedish Energibalansen vid jordytan är av avgörande betydelse för Jordens alla ekosystem men när det gäller Arktiska och sub-Arktiska ekosystem är kunskapen bristfällig. I dynamiska system som klimatsystemet, påverkas utbytet av energi, vatten och växthusgaser av små förändringar i ekosystemen. Syftet med denna avhandling är därför att skapa ökad kunskap och en tydligare bild aThe surface energy balance determines the functioning of any ecosystem on the Earth but is still poorly understood in Arctic and subarctic biomes. In a dynamic system, such as the Earth’s climate, any change in its characteristics modifies the exchange of energy, water, and greenhouse gases between the surface and the atmosphere. Therefore, this thesis aims to draw a conclusive picture of the surf
A model inter-comparison study to examine limiting factors in modelling Australian tropical savannas
The savanna ecosystem is one of the most dominant and complex terrestrial biomes, deriving from a distinct vegetative surface comprised of co-dominant tree and grass populations. While these two vegetation types co-exist functionally, demographically they are not static but are dynamically changing in response to environmental forces such as annual fire events and rainfall variability. Modelling s
Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen
Autoantibody-mediated diseases comprise a heterogeneous group of disorders in which the pathogenic potential of autoantibodies has been clearly demonstrated. In general, their treatment relies on the long-term use of systemic corticosteroids and other immunosuppressants that are associated with considerable adverse reactions. EndoS, an endoglycosidase derived from Streptococcus pyogenes, specifica
Methane fluxes from a small boreal lake measured with the eddy covariance method
Fluxes of methane, CH4, were measured with the eddy covariance (EC) method at a small boreal lake in Sweden. The mean CH4 flux during the growing season of 2013 was 20.1 nmol m−2 s−1 and the median flux was 16 nmol m−2 s−1 (corresponding to 1.7 mmol m−2 d−1 and 1.4 mmol m−2 d−1). Monthly mean values of CH4 flux measured with the EC method were compared with fluxes measured with floating chambers (