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Microbial contamination in coastal environments and groundwater is explored within this thesis, focusing onfecal contamination from anthropogenic sources and microbial community dynamics. The spread andpersistence of microbial contaminants in complex aquatic environments with multiple intermittent and pointsources of contamination, was studied in order to lay a groundwork for developing more robus

Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen

OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o

Fine-grained windblown deposits (loess) in which fossil soils (palaeosols) are preserved are excellent records of past climate. However, so far paleoclimate reconstruction studies conducted on such loess-palaeosol sequences (LPS) in SE Europe were focused on the climate changes of the last one or two glacial-interglacial cycles, while almost no attention has been directed to the climate of the cur

Svensk byggindustri är under förändring. Stora delar av produktionen läggs idag ut på entreprenad och byggföretag förlitar sig på underentreprenörer i större utsträckning än tidigare. Som en del av en global trend av kostnadsreducering inom byggindustrin, försöker byggföretag minimera antalet anställda hantverkare och istället utkontraktera arbete till underentreprenörer i strävan efter organisatoThe organisation of work in the Swedish building sector is changing due to increased subcontracting and the adoption of construction management. In this study, construction management refers to a specific subcontracting regime, in which contractors externalise all parts of the production process and organise work through subcontractors. Echoing global trends of cost-cutting, this externalisation b

Jason Erwin Realizing Malmö’s Neighborhood Functionality and Social Capital Potential The Impacts of High-Speed Transport Infrastructure on Rosengård and Fosie Abstract: Increasingly, urban and suburban areas in many western cities are shaped by the tides of high-speed flows of people and goods. While an integral piece of our socio-economic fabric high-speed transport infrastructure (HSTI), limite

https://www.lumes.lu.se/sites/lumes.lu.se/files/erwin_jason.pdf - 2026-06-20

IntroductionAlthough Chronic Obstructive Pulmonary Disease (COPD) is generally considered a progressive condition with limited reversibility, recent data suggests potential for lung function improvement with exercise. Mechanistic insights into exercise-induced benefits remain limited, but in vitro models offer promise for understanding cellular and molecular changes. This study aims to elucidate t

This dissertation examines the construction of monumental synagogues in nineteenth-century Sweden as a means through which Jewish communities articulated public presence, negotiated belonging, and translated aspirations for civic inclusion into durable architectural form. Focusing on five purpose-built synagogues in Gothenburg (1855), Norrköping (1858), Stockholm (1870), Karlstad (1899), and Malmö

BACKGROUND: Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback-controlled device impacts patient-centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out-of-hospital cardiac arrest. METHODS: The TEMP-CARE trial is part of the 2 × 2 × 2 factoria

Background: In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac arrest and resuscitation (MAP-CARE) trial aiming to investigate the influence of MAP targets on patient outcomes. Methods: MAP-CARE is one component of the Sedati

This thesis project, Spatial Practices of Ageing Well in Place, explores how collaborative housing can be spatially reinterpreted to support ageing in place in low-income, kinship-based rural villages in China. Based on the fieldwork in Quanfang Village, the project proposes a small-scale housing prototype that responds to the weakening of family-based care. Rather than applying collaborative hous

Popular Abstract in Swedish I dag används cellhämmande medel, cytostatika, ofta i kombination med andra metoder för behandling av vissa typer av cancer. Cytostatika kan bota t.ex. leukemi, testikel- och lymfkörtelcancer, eller lindra symtomen och förlänga livet vid t.ex. småcellig lungcancer. En grupp av cytostatika utgörs av metallkomplex där metallen är platina (Pt). Upptäckten av en sådan förenThe kinetics and mechanism for interactions of the anticancer active platinum(II) complexes cis-[PtCl2(NH3)2)], cis-[PtCl2(NH3)(c-C6H11NH2)], and trans-[PtCl2-(NH3)(quinoline)] with DNA have been studied using a combination of HPLC, circular dichroism (CD), UV/vis spectroscopy, and differential scanning calorimetry (DSC). Reactions of the monoaqua forms (charge = +1) of these complexes with single

Arguably among the most globally impactful climate changes in Earth's past million years are the glacial terminations that punctuated the Pleistocene epoch. With the acquisition and analysis of marine and continental records, including ice cores, it is now clear that the Earth's climate was responding profoundly to changes in greenhouse gases that accompanied those glacial terminations. But the u

Popular Abstract in Swedish Antikroppar är viktiga beståndsdelar av det naturliga immunförsvaret som skyddar oss mot smittämnen, såsom bakterier och virus. Utvecklingen av olika genetiska och biokemiska teknologier har dessutom möjliggjort användningen av antikroppar för en mängd ändmål, bl a för diagnostik och behandling av infektionssjukdomar och cancer. I denna avhandling, som bygger på fem vetAntibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. Despite tremendous advances in all fields

Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated significant treatment effects across primary and secondary endpoints. Low-dose aducanumab results were consistent across studies with non-significant differ

Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes. These barcodes can be mapped to theoretical counterparts obtained from DNA reference sequences, which in turn allow for DNA identification in complex samples and for detecting structural changes in individual DNA molecules. Ther

Changes in the geometry of ocean meridional overturning circulation (MOC) are crucial in controlling past changes of climate and the carbon inventory of the atmosphere. However, the accurate timing and global correlation of short-term glacial-to-deglacial changes of MOC in different ocean basins still present a major challenge. The fine structure of jumps and plateaus in atmospheric and planktic r

Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs