Filtyp
Pulchrol, a natural compound isolated from the roots of the vegetal specie Bourreria pulchra has been shown to possess potential antiparasitic activity toward Trypanosomatids, particularly against Trypanosoma cruzi, which causes the Chagas disease; and moderately against Leishmania species, responsible for Leishmaniasis. In this investigation, several pulchrol analogues were prepared and assayed t
Aim: The Eurasian otter (Lutra lutra) is a flagship species for global freshwater ecosystems. As one of the most widely distributed Palearctic mammals, the otter used to inhabit most provinces in China. However, after decades of relentless hunting and habitat degradation, the Sanjiangyuan Region is now one of last strongholds for this species in China. Currently, there still remains an enormous kn
Radar data at C-band has shown great potential for the monitoring of soil and canopy hydric conditions of wheat crops. In this study, the C-band Sentinel-1 time series including the backscattering coefficients σ0 at VV and VH polarization, the polarization ratio (PR) and the interferometric coherence ρ are first analyzed with the support of experimental data gathered on three plots of irrigated wi
Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. Sialic acid plays a crucial role forpathogenic bacteria, since it is used as a source of car
The incorporation of water isotopologues into the hydrology of general circulation models (GCMs) facilitates the comparison between modeled and measured proxy data in paleoclimate archives. However, the variability and drivers of measured and modeled water isotopologues, as well as the diversity of their representation in different models, are not well constrained. Improving our understanding of t
Aims/hypothesis: Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on DKD and by integrating the results with renal transcriptomics datasets. Methods: We performed GWAS meta-analyses us
Polymer materials have wide applications in many industries, such as the food, pharmacy, construction, textile, and cosmetics industries. For the past few years, polymer materials have drawn the attention of scientists and engineers as a good disinfectant due to their advanced manufacturing methods, large surface areas, good stability, and lowcost. More importantly, polymer materials can be functi
Rotavirus (RV) infections remain the leading cause of world-wide diarrhea-associated morbidity and mortality among children <5 years of age. Despite the global introduction of RV vaccines over a decade ago, RV infections result in >200,000 deaths annually mostly in the low-income countries of Africa and Asia. Efficient clearance of the primary RV infection and protection from future re-infections
The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh
Sedan 70-talet har antalet separationer i Sverige ökat med många ombildade familjer till följd. Människor i alla åldrar möter nya partners vilket ofta innebär att också den nya partnerns familjerelationer blir del av ens liv och skapar komplexa familjerelationer i flera led. Nästan hälften av alla frånskilda svenskar är idag i åldrarna 60+ och många av dem lever i, eller har någon gång levt i, omb
Realistic and accurate reconstructions of past vegetation cover are necessary to study past environmental changes. This is important since the effects of human land-use changes (e.g. agriculture, deforestation and afforestation/reforestation) on biodiversity and climate are still under debate. Over the last decade, development, validation, and application of pollen-vegetation relationship models h
The success of social movements is highly dependent on their sustainability, as in their efforts to produce meaningful change, they inevitably encounter oppressive dominant forces. With the advent of the social media era, scholarly research on collective action has acquired an additional dimension, bringing the role of their communicative constitution to the forefront of discussions. However, a de
BACKGROUND: Bisphosphonates have profound effects on bone physiology, and could modify the process of metastasis. We undertook collaborative meta-analyses to clarify the risks and benefits of adjuvant bisphosphonate treatment in breast cancer.METHODS: We sought individual patient data from all unconfounded trials in early breast cancer that randomised between bisphosphonate and control. Primary ou
Mycket forskarmöda har ägnats åt den stora reduktionen i början av 1680-talet, då den svenska adelns förläningar drogs in till kronan och maktbalansen skiftade till den enväldige kungens fördel. Denna forskning har framför allt behandlat den politiska och ekonomiska utvecklingen, ofta ur ett elitperspektiv. Andra gruppers agerande och levda verklighet har sällan blivit belysta, vilket inte minst gA large body of scholarly work has been dedicated to the Swedish reduction in the early 1680s when fiefs granted to the nobility were revoked as the crown strengthened its position. However, this research has focused on political and economic developments from an elite perspective. Insufficient attention has been paid to the actions and lived realities of other groups, not least the servants of th
Insect behaviours, such as host and mate selection, are often mediated by chemical cues. The chemical cuesare detected by large and rapidly evolving families of chemoreceptors which include odorant receptors (ORs),gustatory receptors (GRs) and ionotropic receptors (IRs). In this thesis, I used a model system of beetle(Coleoptera) species to study the functional evolution of insect ORs, their ligan
Objectives: The randomized controlled trial comparing digital breast tomosynthesis and synthetic 2D mammograms (DBT + SM) versus digital mammography (DM) (the To-Be 1 trial), 2016–2017, did not result in higher cancer detection for DBT + SM. We aimed to determine if negative cases prior to interval and consecutive screen-detected cancers from DBT + SM were due to interpretive error. Methods: Five
I juni 2022 röstades ett lagförslag igenom i riksdagen vilket resulterade i att det kostnadsbaserade avdraget för resor till och från arbetet (arbetsresor) ändrades om i grunden till att vara en färdmedelsneutral och avståndsbaserad skattereduktion. Innan de nya reglerna hann träda i kraft den 1 januari 2023 ändrade sig riksdagen och röstade i stället igenom ett förstärkt reseavdrag med höjda schaIn June 2022, a bill was passed through Riksdagen which led to the cost-based write off for traveling to and from your employment (work commute) being changed to accommodate non-specific travel methods and distance based tax deduction. Before the new bills had gone into effect starting from the 1st of january 2023, the Riksdag changed their mind and opted to pass a new bill that allowed for higher
Att analysera livets biokemi, kemin bakom biologiska processer, är viktigt för att få en förståelse av livets mekanismer, speciellt för små längdskalor. Biokemin hos olika typer av celler skiljer sig åt, vilket kan användas för att t.ex skilja mellan elakartade och icke-elakartade tumörer. Vilka ämnen som finns i en cell kan bli identifierade via deras respektive absorptionspektrum. Ett absorptionA hyperspectral image may be decomposed into component spectra and their distri- bution in the image to simplify analysis by revealing underlying patterns and reducing the dimensionality of the image; this may be achieved by the algorithm MCR-ALS. However, the algorithm is time consuming, but could be accelerated by a data re- duction. Data reduction can be done by using a clustering method. In th
Bygg- och fastighetsbranschen står idag för ungefär en femtedel av Sveriges nationella växthusgasutsläpp. Majoriteten av branschens ansträngningar för att minska utsläppen har fram tills idag fokuserat på hållbar nyproduktion och energieffektiviseringar av byggnader vilket har motiverats med att detta har ansetts vara de områden som ger upphov till störst utsläpp. Kommersiella byggnader genomgår dThe construction and real estate industry in Sweden accounts for approximately one-fifth of the country’s national greenhouse gas emissions. Until today, the majority of the industry’s efforts to reduce emissions have focused on sustainable construction of new buildings and energy efficiency improvements of existing buildings, which has been justified by the fact that these have been the areas con
