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Human complement regulators are important targets for pathogenic microorganisms. In one such interaction, Bordetella pertussis binds human C4b-binding protein (C4BP), a high-molecular-weight plasma protein that acts as inhibitor of the classical pathway of complement activation. At least two different B. pertussis surface components, one of which is the virulence factor filamentous hemagglutinin (
According to the thinking-for-speaking (TFS) hypothesis, speakers of different languages think differently while in the process of mentally preparing content for speech. The aim of the present paper is to critically discuss the research carried out within the TFS paradigm, against the background of the basic tenets laid out by the proponents of this framework. We will show that despite substantial
The decay of Bacillus subtilis aprE leader-lacZ mRNA was examined in Escherichia coli wild-type and in mutants deficient in RNase E, RNase G, or both. Two versions of the mRNA were studied: the wild-type mRNA, which has a stem-loop at the 5' end, and a mutant mRNA, with a single-stranded 5' end. The half-life of both transcripts was determined by RNase E, the half-life of the mutant transcript bei
Shallow groundwater in unconsolidated sediments represents a substantial water resource in the Chinese Loess Plateau. However, prior to development of the water supply for agriculture, annual and seasonal fluctuation of the recharge mechanism should be clarified. Since the region is arid, the effect of plant water uptake on groundwater fluctuation must also be assessed. A study was therefore under
Naturliga metanutsläpp sker från våra våtmarker världen över. Metan produceras naturligt genom nedbrytning i de syrefria förhållanden som en våtmark erbjuder. För att bättre kunna modellera och skala upp hur mycker metan som faktiskt släpps ut från dessa våtmarker måste ytterligare förståelse skapas över varför metanutsläppen varierar så kraftigt både i tid och rum. Denna studie försöker öka först
Experimental data on precipitation chemistry were collected at a semi-arid savanna in Senegal (Dahra) in 2013, 2014 and 2017. The chemical composition of precipitation was analyzed for inorganic and organic ions, using ionic chromatography. The pH values of precipitation range from 4.50 to 8.50 with 89% of the samples having basic pH. The composition of precipitation was controlled by four source
Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistant to lamivudine. Results showed that single mutations at residue 184 of RT caused
Background: Infantile neuroaxonal dystrophy (INAD) is a rare hereditary neurological disorder caused by mutations in PLA2G6. The disease commonly affects children below 3 years of age and presents with delay in motor skills, optic atrophy and progressive spastic tetraparesis. Studies of INAD in Africa are extremely rare, and genetic studies from Sub Saharan Africa are almost non-existent. Case pre
Detaljerade data är avgörande vid karaktärisering av komplexa förorenade områden. I denna studie utrustar vi ett antal G360-brunnssystem med Star-Oddi milli-TD-tryckgivare i ett mestadels PCE (tetrakloretylen)- och TCE (trikloretylen)-förorenat bostadsområde i Helsingborg. Trots att dessa tryckgivare vanligtvis används inom marina undersökningar gör deras kostnad samt kompakta storlek dem av intre
Planning and execution of large infrastructure projects benefit from detailed mapping of the subsurface through geophysical methods. However applying geophysical methods in an urban environment requires careful preparation to ensure success in areas where source of noise and present infrastructure may compromise the results. We present and discuss the results of a seismic investigation conducted i
The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA
