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After emigrating from England to Canada in the late 1970s, Robin Wood gained wide recognition as a major “Canadian” film critic, but he was criticized by some for his luke-warm response to the cinema of his adopted country. That response can be traced, in part, to the influence of the English literary critic F.R. Levis, but also to intellectual trends and cultural preferences Wood shared with othe
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This master’s thesis focused on the crystallisation of E. coli ribonucleotide reductase repressor (NrdR) in the scope of fragment-based drug design. Antibiotic resistance is a growing problem and NrdR is thought to be a potential drug target for a new group of antibiotics. NrdR proteins are only found in bacteria and regulate the transcription of ribonucleotide reductase genes by binding to two Nr
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Biomolecular recognition is often characterised by low affinity where many weak interactions work either alone or in concert, resulting in an inherent dynamic situation. For example the well-studied weak binding of cell-cell interactions is predominantly based on a range of carbohydrates that interact with numerous (protein) ligands. Finding appropriate binders to these carbohydrate structures may